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Volumn 13, Issue 4, 2009, Pages 385-394

Novel therapeutic targets in Plasmodium falciparum: Aquaglyceroporins

Author keywords

Aquaglyceroporin; Aquaporin; Attenuated parasites; Dihydroxyacetone; Gene knockout; Glycosylation; Mutation; Plasmodium berghei; Plasmodium falciparum; Poverty related disease

Indexed keywords

2 PROPANOL; AQUAGLYCEROPORIN; AQUAPORIN 1; AQUAPORIN 2; AQUAPORIN 3; AQUAPORIN 4; ARTEMISININ; CHLOROQUINE; HYDROXYUREA; PYRIMETHAMINE; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; SULFADOXINE; ANTIMALARIAL AGENT; CYTOTOXIN; DIHYDROXYACETONE; GLYCEROL; PFAQP PROTEIN, PLASMODIUM FALCIPARUM; PORIN; PROTOZOAL PROTEIN; TETRYLAMMONIUM; WATER;

EID: 67649225438     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728220902817839     Document Type: Review
Times cited : (15)

References (48)
  • 1
    • 57749099137 scopus 로고    scopus 로고
    • Evidence of artemisinin-resistant malaria in western Cambodia
    • Describes the possible start of artemisinin resistance
    • Noedl H, Se Y, Schaecher K, et al. Evidence of artemisinin-resistant malaria in western Cambodia. N Engl J Med 2008;359:2619-2620 •• Describes the possible start of artemisinin resistance.
    • (2008) N Engl J Med , vol.359 , pp. 2619-2620
    • Noedl, H.1    Se, Y.2    Schaecher, K.3
  • 3
    • 55449124885 scopus 로고    scopus 로고
    • Yeast model uncovers dual roles of mitochondria in action of artemisinin
    • published online 16 September, 2005, doi:10.1371/journal.pgen.0010036
    • Li W, Mo W, Shen D, et al. Yeast model uncovers dual roles of mitochondria in action of artemisinin. PLoS Genet 2005;1:e36. published online 16 September, 2005, doi:10.1371/journal.pgen.0010036
    • (2005) PLoS Genet , vol.1
    • Li, W.1    Mo, W.2    Shen, D.3
  • 4
    • 3342910277 scopus 로고    scopus 로고
    • Unraveling the mode of action of the antimalarial choline analog G25 in Plasmodium falciparum and Saccharomyces cerevisiae
    • DOI 10.1128/AAC.48.8.2816-2824.2004
    • Roggero R, Zufferey R, Minca M, et al. Unraveling the mode of action of the antimalarial choline analog G25 in Plasmodium falciparum and Saccharomyces cerevisiae. Antimicrob Agents Chemother 2004;48:2816-2824 (Pubitemid 38989141)
    • (2004) Antimicrobial Agents and Chemotherapy , vol.48 , Issue.8 , pp. 2816-2824
    • Roggero, R.1    Zufferey, R.2    Minca, M.3    Richier, E.4    Calas, M.5    Vial, H.6    Mamoun, C.B.7
  • 6
    • 0036861867 scopus 로고    scopus 로고
    • Choline transport in Leishmania major promastigotes and its inhibition by choline and phosphocholine analogs
    • PII S0166685102002207
    • Zufferey R, Mamoun Cb. Choline transport in Leishmania major promastigotes and its inhibition by choline and phosphocholine analogs. Mol biochem Parasitol 2002;125:127-134 (Pubitemid 35449252)
    • (2002) Molecular and Biochemical Parasitology , vol.125 , Issue.1-2 , pp. 127-134
    • Zufferey, R.1    Mamoun, C.B.2
  • 7
    • 40749109892 scopus 로고    scopus 로고
    • Monoquaternary ammonium derivatives inhibit growth of protozoan parasites
    • Bahamontes-Rosa N, Robin A, Ambrosio AR, et al. Monoquaternary ammonium derivatives inhibit growth of protozoan parasites. Parasitol Int 2008;57:132-137
    • (2008) Parasitol Int , vol.57 , pp. 132-137
    • Bahamontes-Rosa, N.1    Robin, A.2    Ambrosio, A.R.3
  • 8
    • 0032853219 scopus 로고    scopus 로고
    • Cellular and molecular biology of the aquaporin water channels
    • DOI 10.1146/annurev.biochem.68.1.425
    • Borgnia M, Nielsen S, Engel A, et al. Cellular and molecular biology of the aquaporin water channels. Annu Rev Biochem 1999;68:425-458 (Pubitemid 29449199)
    • (1999) Annual Review of Biochemistry , vol.68 , pp. 425-458
    • Borgnia, M.1    Nielsen, So.2    Engel, A.3    Agre, P.4
  • 9
    • 0031011374 scopus 로고    scopus 로고
    • Three-dimensional organization of a human water channel
    • DOI 10.1038/42517
    • Cheng A, van Hoek AN, Yeager M, et al. Three-dimensional organization of a human water channel. Nature 1997;387:627-630 •• Presents the first AQP crystal structure. (Pubitemid 27248770)
    • (1997) Nature , vol.387 , Issue.6633 , pp. 627-630
    • Cheng, A.1    Van Hoek, A.N.2    Yeager, M.3    Verkman, A.S.4    Mitra, A.K.5
  • 14
    • 0034161393 scopus 로고    scopus 로고
    • The importance of aquaporin water channel protein structures
    • Engel A, Fujiyoshi Y, Agre P. The importance of aquaporin water channel protein structures. EMBO J 2000;19:800-806 (Pubitemid 30119806)
    • (2000) EMBO Journal , vol.19 , Issue.5 , pp. 800-806
    • Engel, A.1    Fujiyoshi, Y.2    Agre, P.3
  • 15
    • 0035924329 scopus 로고    scopus 로고
    • Structural basis of water-specific transport through the AQP1 water channel
    • DOI 10.1038/414872a
    • Sui H, Han BG, Lee JK, et al. Structural basis of water-specific transport through the AQP1 water channel. Nature 2001;414:872-878 (Pubitemid 34024731)
    • (2001) Nature , vol.414 , Issue.6866 , pp. 872-878
    • Sui, H.1    Han, B.-G.2    Lee, J.K.3    Walian, P.4    Jap, B.K.5
  • 17
    • 0034014858 scopus 로고    scopus 로고
    • Inhibition of aquaporin-1 water permeability by tetraethylammonium: Involvement of the loop e pore region
    • Brooks HL, Regan JW, Yool AJ. Inhibition of aquaporin-1 water permeability by tetraethylammonium: involvement of the loop E pore region. Mol Pharmacol 2000;57:1021-1026 (Pubitemid 30253387)
    • (2000) Molecular Pharmacology , vol.57 , Issue.5 , pp. 1021-1026
    • Brooks, H.L.1    Regan, J.W.2    Yool, A.J.3
  • 19
    • 0028088012 scopus 로고
    • Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels
    • Preston GM, Smith BL, Zeidel ML, et al. Mutations in aquaporin-1 in phenotypically normal humans without functional CHIP water channels. Science 1994;265:1585-1587 • Describes the benignity of AQP deficiency. (Pubitemid 24308974)
    • (1994) Science , vol.265 , Issue.5178 , pp. 1585-1587
    • Preston, G.M.1    Smith, B.L.2    Zeidel, M.L.3    Moulds, J.J.4    Agre, P.5
  • 20
    • 0027976658 scopus 로고
    • Membrane topology of aquaporin CHIP: Analysis of functional epitope-scanning mutants by vectorial proteolysis
    • Preston GM, Jung JS, Guggino WB, et al. Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis. J Biol Chem 1994;269:1668-1673 (Pubitemid 24978446)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.3 , pp. 1668-1673
    • Prestoni, G.M.1    Jung, J.S.2    Guggino, W.B.3    Agre, P.4
  • 21
    • 0026548681 scopus 로고
    • Apparent lack of N-glycosylation in the asexual intraerythrocytic stage of Plasmodium falciparum
    • Dieckmann-Schuppert A, Bender S, Odenthal-Schnittler M, et al. Apparent lack of N-glycosylation in the asexual intraerythrocytic stage of Plasmodium falciparum. Eur J Biochem 1992;205:815-825
    • (1992) Eur J Biochem , vol.205 , pp. 815-825
    • Dieckmann-Schuppert, A.1    Bender, S.2    Odenthal-Schnittler, M.3
  • 22
    • 0034074496 scopus 로고    scopus 로고
    • Plasmodium falciparum: Merozoite surface proteins 1 and 2 are not posttranslationally modified by classical N- Or O-glycans
    • DOI 10.1006/expr.1999.4481
    • Berhe S, Gerold P, Kedees MH, et al. Plasmodium falciparum: merozoite surface proteins 1 and 2 are not posttranslationally modified by classical N- or O-glycans. Exp Parasitol 2000;94:194-197 (Pubitemid 30333400)
    • (2000) Experimental Parasitology , vol.94 , Issue.3 , pp. 194-197
    • Berhe, S.1    Gerold, P.2    Kedees, M.H.3    Holder, A.A.4    Schwarz, R.T.5
  • 23
    • 15844362771 scopus 로고    scopus 로고
    • N-linked glycoproteins are related to schizogony of the intraerythrocytic stage in Plasmodium falciparum
    • DOI 10.1074/jbc.271.24.14452
    • Kimura EA, Couto AS, Peres VJ, et al. N-linked glycoproteins are related to schizogony of the intraerythrocytic stage in Plasmodium falciparum. J Biol Chem 1996;271:14452-14461 (Pubitemid 26190345)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.24 , pp. 14452-14461
    • Kimura, E.A.1    Couto, A.S.2    Peres, V.J.3    Casal, O.L.4    Katzin, A.M.5
  • 24
    • 1642442461 scopus 로고    scopus 로고
    • Channels and transporters as drug targets in the Plasmodium-infected erythrocyte
    • DOI 10.1016/j.actatropica.2003.10.002
    • Kirk K. Channels and transporters as drug targets in the Plasmodium-infected erythrocyte. Acta Trop 2004;89:285-298 (Pubitemid 38117065)
    • (2004) Acta Tropica , vol.89 , Issue.3 , pp. 285-298
    • Kirk, K.1
  • 25
    • 44049097547 scopus 로고    scopus 로고
    • Mammalian aquaporins: Diverse physiological roles and potential clinical significance
    • DOI 10.1017/S1462399408000690, PII S1462399408000690
    • Verkman AS. Mammalian aquaporins: diverse physiological roles and potential clinical significance. Expert Rev Mol Med 2008;10:e13 (Pubitemid 351712537)
    • (2008) Expert Reviews in Molecular Medicine , vol.10 , Issue.13 , pp. 1-18
    • Verkman, A.S.1
  • 28
    • 0033971773 scopus 로고    scopus 로고
    • Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method
    • DOI 10.1085/jgp.115.1.17
    • Song Y, Ma T, Matthay MA, et al. Role of aquaporin-4 in airspace-to-capillary water permeability in intact mouse lung measured by a novel gravimetric method. J Gen Physiol 1999;115:17-27 • Describes the effects of double AQP knockout mice. (Pubitemid 30043664)
    • (2000) Journal of General Physiology , vol.115 , Issue.1 , pp. 17-27
    • Song, Y.1    Ma, T.2    Matthay, M.A.3    Verkman, A.S.4
  • 29
    • 0035808368 scopus 로고    scopus 로고
    • Erythrocyte water permeability and renal function in double knock out mice lacking aquaporin-1 and aquaporin-3
    • DOI 10.1074/jbc.M008664200
    • Yang B, Ma T, Verkman AS. Erythrocyte water permeability and renal function in double knockout mice lacking aquaporin-1 and aquaporin-3. J Biol Chem 2001;276:624-628 • Describes the effects of double AQP knockout mice. (Pubitemid 32050358)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.1 , pp. 624-628
    • Yang, B.1    Ma, T.2    Verkman, A.S.3
  • 30
    • 0842342619 scopus 로고    scopus 로고
    • Molecular dissection of water and glycerol permeability of the aquaglyceroporin from Plasmodium falciparum by mutational analysis
    • An in-depth analysis of important residues in AQP function of P. falciparum
    • Beitz E, Pavlovic-Djuranovic S, Yasui M, et al. Molecular dissection of water and glycerol permeability of the aquaglyceroporin from Plasmodium falciparum by mutational analysis. Proc Natl Acad Sci USA 2004;101:1153-8 • An in-depth analysis of important residues in AQP function of P. falciparum.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1153-1158
    • Beitz, E.1    Pavlovic-Djuranovic, S.2    Yasui, M.3
  • 32
    • 34548131086 scopus 로고    scopus 로고
    • Microwave-assisted ring opening of epoxides: A general route to the synthesis of 1-aminopropan-2-ols with anti malaria parasite activities
    • DOI 10.1021/jm070553l
    • Robin A, Brown F, Bahamontes-Rosa N, et al. Microwave-assisted ring opening of epoxides: a general route to the synthesis of 1-aminopropan-2-ols with anti malaria parasite activities. J Med Chem 2007;50:4243-4249 (Pubitemid 47301755)
    • (2007) Journal of Medicinal Chemistry , vol.50 , Issue.17 , pp. 4243-4249
    • Robin, A.1    Brown, F.2    Bahamontes-Rosa, N.3    Wu, B.4    Beitz, E.5    Kun, J.F.J.6    Flitsch, S.L.7
  • 34
    • 42149097940 scopus 로고    scopus 로고
    • Malaria vaccines: The case for a whole-organism approach
    • DOI 10.1517/14712598.8.4.441
    • Pinzon-Charry A, Good MF. Malaria vaccines: the case for a whole-organism approach. Expert Opin Biol Ther 2008;8:441-448 (Pubitemid 351596089)
    • (2008) Expert Opinion on Biological Therapy , vol.8 , Issue.4 , pp. 441-448
    • Pinzon-Charry, A.1    Good, M.F.2
  • 35
    • 0016740645 scopus 로고
    • Immunization of man against falciparum and vivax malaria by use of attenuated sporozoites
    • Clyde DF, McCarthy VC, Miller RM, et al. Immunization of man against falciparum and vivax malaria by use of attenuated sporozoites. Am J Trop Med Hyg 1975;24:397-401
    • (1975) Am J Trop Med Hyg , vol.24 , pp. 397-401
    • Clyde, D.F.1    McCarthy, V.C.2    Miller, R.M.3
  • 36
    • 0015699215 scopus 로고
    • Immunization of man against sporozite-induced falciparum malaria
    • Clyde DF, Most H, McCarthy VC, et al. Immunization of man against sporozite-induced falciparum malaria. Am J Med Sci 1973;266:169-177
    • (1973) Am J Med Sci , vol.266 , pp. 169-177
    • Clyde, D.F.1    Most, H.2    McCarthy, V.C.3
  • 37
    • 0014202885 scopus 로고
    • Protective immunity produced by the injection of X-irradiated sporozoites of Plasmodium berghei
    • Nussenzweig RS, Vanderberg J, Most H, et al. Protective immunity produced by the injection of X-irradiated sporozoites of Plasmodium berghei. Nature 1967;216:160-162
    • (1967) Nature , vol.216 , pp. 160-162
    • Nussenzweig, R.S.1    Vanderberg, J.2    Most, H.3
  • 38
    • 0347627545 scopus 로고    scopus 로고
    • A single aquaporin gene encodes a water/glycerol/urea facilitator in Toxoplasma gondii with similarity to plant tonoplast intrinsic proteins
    • DOI 10.1016/S0014-5793(03)01313-9
    • Pavlovic-Djuranovic S, Schultz JE, Beitz E. A single aquaporin gene encodes a water/glycerol/urea facilitator in Toxoplasma gondii with similarity to plant tonoplast intrinsic proteins. FEbS Lett 2003;555:500-504 (Pubitemid 37532600)
    • (2003) FEBS Letters , vol.555 , Issue.3 , pp. 500-504
    • Pavlovic-Djuranovic, S.1    Schultz, J.E.2    Beitz, E.3
  • 39
    • 33748523475 scopus 로고    scopus 로고
    • Dihydroxyacetone and methylglyoxal as permeants of the Plasmodium aquaglyceroporin inhibit parasite proliferation
    • DOI 10.1016/j.bbamem.2005.12.002, PII S0005273605003962, Auquporins
    • Pavlovic-Djuranovic S, Kun JF, Schultz JE, et al. Dihydroxyacetone and methylglyoxal as permeants of the Plasmodium aquaglyceroporin inhibit parasite proliferation. Biochim Biophys Acta 2006;1758:1012-1017 (Pubitemid 44373850)
    • (2006) Biochimica et Biophysica Acta - Biomembranes , vol.1758 , Issue.8 , pp. 1012-1017
    • Pavlovic-Djuranovic, S.1    Kun, J.F.J.2    Schultz, J.E.3    Beitz, E.4
  • 42
    • 0020384963 scopus 로고
    • Hydroxyurea inhibition of growth and DNA synthesis in Toxoplasma gondii: Characterization of a resistant mutant
    • DOI 10.1016/0166-6851(82)90073-1
    • Kasper LH, Pfefferkorn ER. Hydroxyurea inhibition of growth and DNA synthesis in Toxoplasma gondii: characterization of a resistant mutant. Mol biochem Parasitol 1982;6:141-150 (Pubitemid 13242841)
    • (1982) Molecular and Biochemical Parasitology , vol.6 , Issue.3 , pp. 141-150
    • Kasper, L.H.1    Pfefferkorn, E.R.2
  • 43
    • 0031680657 scopus 로고    scopus 로고
    • Antimalarial activities of polyhydroxyphenyl and hydroxamic acid derivatives
    • Holland KP, Elford HL, bracchi V, et al. Antimalarial activities of polyhydroxyphenyl and hydroxamic acid derivatives. Antimicrob Agents Chemother 1998;42:2456-2458
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 2456-2458
    • Holland, K.P.1    Elford, H.L.2    Bracchi, V.3
  • 46
    • 0037145839 scopus 로고    scopus 로고
    • New potent inhibitors of aquaporins: Silver and gold compounds inhibit aquaporins of plant and human origin
    • DOI 10.1016/S0014-5793(02)03581-0, PII S0014579302035810
    • Niemietz CM, Tyerman SD. New potent inhibitors of aquaporins: silver and gold compounds inhibit aquaporins of plant and human origin. FEBS Lett 2002;531:443-447 (Pubitemid 35336066)
    • (2002) FEBS Letters , vol.531 , Issue.3 , pp. 443-447
    • Niemietz, C.M.1    Tyerman, S.D.2
  • 47
    • 50249103780 scopus 로고    scopus 로고
    • Chemically attenuated Plasmodium sporozoites induce specific immune responses, sterile immunity and cross-protection against heterologous challenge
    • Purcell LA, Wong KA, Yanow SK, et al. Chemically attenuated Plasmodium sporozoites induce specific immune responses, sterile immunity and cross-protection against heterologous challenge. Vaccine 2008;26:4880-4884
    • (2008) Vaccine , vol.26 , pp. 4880-4884
    • Purcell, L.A.1    Wong, K.A.2    Yanow, S.K.3
  • 48
    • 67649749686 scopus 로고    scopus 로고
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