Toxicity of manufactured zinc oxide nanoparticles in the nematode Caenorhabditis elegans

Environmental Toxicology and Chemistry

Volumn 28, Issue 6, 2009, Pages 1324-1330

  Ma, Hongbo ^a   Bertsch, Paul M ^b   Glenn, Travis C ^a   Kabengi, Nadine J ^c   Williams, Phillip L ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF GEORGIA   (United States)

Author keywords

Caenorhabditis elegans; Toxicity; Zinc chloride; Zinc oxide nanoparticles

Indexed keywords

BEHAVIORAL CHANGES; CAENORHABDITIS ELEGANS; CONFIDENCE INTERVAL; ECOLOGICAL RECEPTORS; EFFECTIVE CONCENTRATION; ELEGANS; FREE-LIVING NEMATODES; GENE PROMOTER; GREEN FLUORESCENCE PROTEINS; HUMAN HEALTH; MEDIAN LETHAL CONCENTRATION; METALLOTHIONEIN; TOXICOLOGICAL EFFECTS; TRANSGENE EXPRESSION; TRANSGENIC; TRANSGENIC STRAINS; ZINC CHLORIDE; ZINC OXIDE NANOPARTICLES; ZNO;

CHLORINE COMPOUNDS; DISSOLUTION; GENE ENCODING; NANOPARTICLES; SEMICONDUCTING ZINC COMPOUNDS; TOXICITY; ZINC OXIDE;

ZINC;

GREEN FLUORESCENT PROTEIN; METALLOTHIONEIN II; NANOPARTICLE; ZINC; ZINC CHLORIDE; ZINC OXIDE;

BIOTRANSFORMATION; GENE EXPRESSION; MORTALITY; NEMATODE; OXIDE; TOXICITY TEST; ZINC;

ARTICLE; BEHAVIOR CHANGE; BIOTRANSFORMATION; CAENORHABDITIS ELEGANS; CELL TRANSFORMATION; CONFIDENCE INTERVAL; CONTROLLED STUDY; ECOTOXICOLOGY; GENE EXPRESSION; LC 50; LETHALITY; NEMATODE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPRODUCTION; TRANSGENE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; GREEN FLUORESCENT PROTEINS; METAL NANOPARTICLES; REPRODUCTION; ZINC OXIDE;

CAENORHABDITIS ELEGANS;

EID: 67649221751     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/08-262.1     Document Type: Article

References (40)

1. European Union Scientific Committee on Emerging or Newly Identified Health Risks (SCENIHR). 2007. The appropriateness of the risk assessment methodology in accordance with the technical guidance documents for new and existing substances for assessing the risks of nanomaterials. Brussels, Belgium, pp 13-15.
2. Masciangiol T, Zhang W. 2003. Environmental technologies at the nanoscale. Environ Sci Technol 37:102A-108A. (Pubitemid 36504778)
3. Colvin VL. 2003. The potential environmental impact of engineered nanomaterials. Nat Biotechnol 21:1166-1170. (Pubitemid 37203347)
4. Thomas K, Sayre P. 2005. Research strategies for safety evaluation of nanomaterials, Part I: Evaluating the human health implications of exposure to nanoscale materials. Toxicol Sci 87: 316-321. (Pubitemid 41300678)
5. U.S. Environmental Protection Agency. 2005. Nanotechnology and the Environment: Applications and Implications Progress Review Workshop III. Office of Research and Development, Washington, DC.
6. Service RF. 2004. Nanotoxicology: Nanotechnology grows up. Science 304:1732-1734.
7. Holsapple MP, Farland WH, Landry TD, Monteiro-Riviere NA, Carter JM, Walker NJ, Thomas KV. 2005. Research strategies for safety evaluation of nanomaterials, Part II: Toxicological and safety evaluation of nanomaterials, current challenges and data needs. Toxicol Sci 88:12-17. (Pubitemid 41548742)
8. Braydich-Stolle L, Hussain S, Schlager JJ, Hofmann MC. 2005. In vitro cytotoxicity of nanoparticles in mammalian germlinestem cells. Toxicol Sci 88:412-419. (Pubitemid 41672149)
9. 2, and ZnO water suspensions. Water Res 40:3527-3532. (Pubitemid 44527981)
10. 60) nanoparticles. Environ Toxicol Chem 25:1132-1137. (Pubitemid 46100059)
11. 60) induce oxidative stress in the brain of juvenile largemouth bass. Environ Health Perspect 112:1058-1062. (Pubitemid 39029159)
12. 60) on aquatic organisms. Carbon 44:1112-1120. (Pubitemid 43202168)
13. 60) in two aquatic species, Daphnia and fathead minnow. Mar Environ Res 62:S5-S9. (Pubitemid 43884925)
14. Wang ZL. 2004. Zinc oxide nanostructures: Growth, properties, and applications. Journal of Physics: Condensed Matter 16: R829-R858.
15. Boyd WA, Williams PL. 2003. Comparison of the sensitivity of three nematode species to copper and their utility in aquatic and soil toxicity tests. Environ Toxicol Chem 22:2768-2774. (Pubitemid 37214764)
16. The Caenorhabditis elegans Sequencing Consortium. 1998. Genome sequence of the nematode Caenorhabditis elegans: A platform for investigating biology. Science 282:2012-2018.
17. David HE, Dawe AS, de Pomerai DI, Jones D, Candido EP, Daniells C. 2003. Construction and evaluation of a transgenic hsp16-GFP-lacZ Caenorhabditis elegans strain for environmental monitoring. Environ Toxicol Chem 22:111-118.
18. Cioci LK, Qiu L, Freedman JH. 2000. Transgenic strains of the nematode Caenorhabditis elegans as biomonitors of metal contamination. Environ Toxicol Chem 19:2122-2129. (Pubitemid 30599915)
19. Chu KW, Chan SK, Chow KL. 2005. Improvement of heavy metal stress and toxicity assays by coupling a transgenic reporter in a mutant nematode strain. Aquat Toxicol 74:320-332. (Pubitemid 41219559)
20. Anderson GL, Boyd WA, Williams PL. 2001. Assessment of sublethal endpoints for toxicity testing with the nematode Caenorhabditis elegans. Environ Toxicol Chem 20:833-838.
21. Ma H, Glenn TC, Jagoe CH, Jones KL, Williams PL. 2009. A transgenic strain of the nematode Caenorhabditis elegans as a biomonitor for heavy metal contamination. Environ Toxicol Chem 28:1311-1318.
22. Williams PL, Dusenbery DB. 1990. Aquatic toxicology testing using the nematode Caenorhabditis elegans. Environ Toxicol Chem 9:1285-1290.
23. Cassada RC, Russel RL. 1975. The dauer larvae, a postembryonic developmental variant of the nematode Caenorhabditis elegans. Dev Biol 46:326-342.
24. Donkin SG, Williams PL. 1995. Influence of developmental stage, salts and food presence on various end points using Caenorhabditis elegans for aquatic toxicity testing. Environ Toxicol Chem 14:2139-2147.
25. Freeman MN, Marse TJ, Williams PL. 1998. Establishment of quality assurance procedures for aquatic toxicity testing with the nematode Caenorhabditis elegans. In Little EE, DeLonay AJ, Greenberg BM, eds, Environmental Toxicology and Risk Assessment, Vol 7. STP 1333. American Society for Testing and Materials, West Conshohocken, PA, pp 45-59.
26. Boyd W, Anderson GL, Dusenbery DB, Williams PL. 2000. Computer tracking method for assessing behavioral changes in the nematode Caenorhabditis elegans. In Price FT, Brix KV, Lane NK, eds, Environmental Toxicology and Risk Assessment, Vol 9. STP 1381. American Society for Testing and Materials, Philadelphia, PA, pp 225-238.
27. Dusenbery D. 1997. NIH Image, Ver 1.59. School of Biology, Georgia Institute of Technology, Atlanta, GA, USA.
28. Dhawan R, Dusenbery DB, Williams PL. 1999. Comparison of lethality, reproduction, and behavior as toxicological endpoints in the nematode Caenorhabditis elegans. J Toxicol Environ Health 58:451-462.
29. Middendorf P, Dusenbery D. 1993. Fluoroacetic acid is a potent and specific inhibitor of reproduction in the nematode Caenorhabditis elegans. J Nematol 25:573-577.
30. Environmental Canada. 2005. Guidance document on statistical methods for environmental toxicity tests. EPS 1/RM/ 46. Ottawa, ON.
31. 2) on algae and daphnids. Environ Sci Pollut Res. 13:225-232. (Pubitemid 44140726)
32. Donkin SG, Ohlson DL, Teaf CM. 2000. Properties and effects of metals. In Williams P, James R, Roberts S, eds, Principles of Toxicology: Environmental and Industrial Applications. Wiley, New York, NY, USA, pp 331-334.
33. Nel A, Xia T, Madler L, Li N. 2006. Toxic potential of materials at the nanolevel. Science 311:622-627. (Pubitemid 43191298)
34. 2 to a freshwater microalga (Pseudokirchneriella subcapitata): The importance of particle solubility. Environ Sci Technol 41:8484-8490. (Pubitemid 350276460)
35. Huang F, Bitten G, Kong I-C. 1999. Determination of the heavy metal binding capacity of aquatic samples using MetPLATETM: A preliminary study. Sci Total Environ 234:139-145. (Pubitemid 29392998)
36. Anderson GL, Cole RD, Williams PL. 2004. Assessing behavioral toxicity with Caenorhabditis elegans. Environ Toxicol Chem 23: 1235-1240.
37. Freedman JH, Slice LW, Dixon D, Fire A, Rubin CS. 1993. The novel metallothionein genes of Caenorhabditis elegans - Structural organization and inducible, cell-specific expression. J Biol Chem 268:2554-2564. (Pubitemid 23057878)
38. Swain SC, Keusekotten K, Baumeister R, Sturzenbaum SR. 2004. Caenorhabditis elegans metallothioneins: New insights into the phenotypic effects of cadmium toxicosis. J Mol Biol 341:951-959. (Pubitemid 39037356)
39. Soto KF, Carrasco A, Powell TG, Garza KM, Murr LE. 2005. Comparative in vitro cytotoxicity assessment of some manufactured nanoparticulate materials characterized by transmission-electron microscopy. J Nanoparticle Res 7:145-169. (Pubitemid 40940543)
40. Hoet P, Bruske-Hohlfeld I, Salata O. 2004. Nanoparticles - Known and unknown health risks. J Nanoblotechnol 2:12. (Pubitemid 40230507)