Resistance to bacitracin in Streptococcus pyogenes from oropharyngeal colonization and noninvasive infections in Portugal was caused by two clones of distinct virulence genotypes

FEMS Microbiology Letters

Volumn 296, Issue 2, 2009, Pages 235-240

  Pires, Renato ^a   Rolo, Dora ^a,f   Mato, Rosario ^b   Feio De Almeida, Joao ^a   Johansson, Christina ^c   Henriques Normark, Birgitta ^c   Morais, Ana ^d   Brito Avo, Antonio ^d   Gonalo Marques, Jose ^e   Santos Sanches, Ilda ^a  

^a UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^c SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

^d Ministerio da Saude Portuguese   (Portugal)

^e HOSPITAL DE SANTA MARIA   (Portugal)

^f HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

Bacitracin; Colonization; Infection; Resistance; Streptococcus pyogenes; Virulence

Indexed keywords

ABC TRANSPORTER; AZITHROMYCIN; BACITRACIN; CLARITHROMYCIN; CLINDAMYCIN; ERYTHROMYCIN; EXOTOXIN; INVASIN; LINCOSAMIDE; MACROLIDE; SUPERANTIGEN; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL INFECTION; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM DETECTION; BACTERIUM ISOLATE; CLINICAL ARTICLE; CONTROLLED STUDY; ENTEROCOCCUS FAECALIS; EUROPE; GENE EXPRESSION PROFILING; GENOTYPE; HUMAN; MOLECULAR CLONING; NONHUMAN; OPERON; OROPHARYNX; PHARYNGITIS; PORTUGAL; PRIORITY JOURNAL; STREPTOCOCCAL PHARYNGITIS; STREPTOCOCCUS PYOGENES; TONSILLITIS;

ANTI-BACTERIAL AGENTS; BACITRACIN; BACTERIAL PROTEINS; BACTERIAL TYPING TECHNIQUES; CARRIER STATE; CLUSTER ANALYSIS; DNA FINGERPRINTING; DRUG RESISTANCE, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; GENOTYPE; HUMANS; LINCOSAMIDES; MACROLIDES; OROPHARYNX; PHARYNGITIS; PORTUGAL; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PYOGENES; STREPTOGRAMIN B; TONSILLITIS; VIRULENCE FACTORS;

ENTEROCOCCUS FAECALIS; STREPTOCOCCUS PYOGENES;

EID: 67649221403     PISSN: 03781097     EISSN: 15746968     Source Type: Journal    
DOI: 10.1111/j.1574-6968.2009.01642.x     Document Type: Article

References (25)

1. Cain BD, Norton PJ, Eubanks W, Nick HS Allen CM (1993) Amplification of the bacA gene confers bacitracin resistance to Escherichia coli. J Bacteriol 175 : 3784 3789. (Pubitemid 23173340)
2. Chalker AF, Ingraham KA, Lunsford RD, Bryant AP, Bryant J, Wallis NG, Broskey JP, Pearson SC Holmes DJ (2000) The bacA gene, which determines bacitracin susceptibility in Streptococcus pneumoniae and Staphylococcus aureus, is also required for virulence. Microbiology 146 : 1547 1553. (Pubitemid 30458709)
3. Chung M, de Lencastre H, Matthews P et al 2000) Molecular typing of methicillin-resistant Staphylococcus aureus by pulsed-field gel electrophoresis: comparison of results obtained in a multilaboratory effort using identical protocols and MRSA strains. Microb Drug Resist 6 : 189 198.
4. Clinical and Laboratory Standards Institute (formerly National Committee for Clinical Laboratory Standards) (2000) Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Growth Aerobically. Approved Standard M7-A5, 5th edn. National Committee for Laboratory Standards, Wayne, PA.
5. Creti R, Imperi M, Baldassarri L, Pataracchia M, Recchia S, Alfarone G Orefici G (2007) emm types, virulence factors, and antibiotic resistance of invasive Streptococcus pyogenes isolates from Italy: what has changed in 11 years? J Clin Microbiol 45 : 2249 2256. (Pubitemid 47203800)
6. Cunningham MW (2000) Pathogenesis of Group A streptococcal infections. Clin Microbiol Rev 13 : 470 511. (Pubitemid 30452618)
7. Ekelund K, Darenberg J, Norrby-Teglund A, Hoffmann S, Bang D, Skinhøj P Konradsen HB (2005) Variation in emm type among Group A streptococcal isolates causing invasive or noninvasive infections in a nationwide study. J Clin Microbiol 43 : 3101 3109. (Pubitemid 40981308)
8. Facklam R (2002) What happened to the streptococci: overview of taxonomic and nomenclature changes. Clin Microbiol Rev 15 : 613 630. (Pubitemid 41184081)
9. Friães A, Ramirez M, Melo-Cristino J The Portuguese Surveillance Group for the Study of Streptococcal Infections (2007) Nonoutbreak surveillance of Group A streptococci causing invasive disease in Portugal identified internationally disseminated clones among members of a genetic heterogeneous population. J Clin Microbiol 45 : 2044 2047. (Pubitemid 46933958)
10. Jasir A, Tanna A, Efstratiou A Schalén C (2001) Unusual occurrence of M type 77, antibiotic-resistant Group A streptococci in Southern Sweden. J Clin Microbiol 39 : 586 590. (Pubitemid 32150822)
11. Malhotra-Kumar S, Wang S, Lammens C, Chapelle S Goossens H (2003) Bacitracin-resistant clone of Streptococcus pyogenes isolated from pharyngitis patients in Belgium. J Clin Microbiol 41 : 5282 5284. (Pubitemid 37429961)
12. Manson JM, Keis S, Smith JMB Cook GM (2004) Acquired bacitracin resistance in Enterococcus faecalis is mediated by an ABC transporter and a novel regulatory protein, BcrR. Antimicrob Agents Ch 48 : 3743 3748. (Pubitemid 39304598)
13. Matos R, Pinto VV, Ruivo M Lopes MFS (2009) Study on the dissemination of the bcrABDR-cluster in Enterococcus spp. reveals that BcrAB transporter is sufficient to confer high-level bacitracin resistance. Int J Antimicrob Ag DOI :.
14. Mihaila-Amrouche L, Bouvet A Loubinoux J (2004) Clonal spread of emm type 28 isolates of Streptococcus pyogenes that are multiresistant to antibiotics. J Clin Microbiol 42 : 3844 3846. (Pubitemid 39045727)
15. Pérez-Trallero E, Garcia C, Orden B, Marimon JM Montes M (2004) Dissemination of emm28 erythromycin-, clindamycin- and bacitracin-resistant Streptococcus pyogenes in Spain. Eur J Microbiol Infect Dis 23 : 123 126. (Pubitemid 38392141)
16. B phenotype of macrolide resistance in Spain, 1999 to 2005. Antimicrob Agents Ch 51 : 1228 1233. (Pubitemid 46586798)
17. Pires R, Rolo D, Gama-Norton L et al 2005) Group A streptococci from carriage and disease in Portugal: evolution of antimicrobial resistance and T antigenic types during 2000-2002. Microb Drug Resist 11 : 360 370. (Pubitemid 43099774)
18. Podelsek Z, Comino A, Herzog-Velikonja B, Zgur-Bertok D, Komel R Grabnar M (1995) Bacillus licheniformis bacitracin resistance ABC transporter: relationship to mammalian multidrug resistance. Mol Microbiol 16 : 969 976.
19. Schmitz FJ, Beyer A, Charpentier E, Henriques-Normark B, Schade M, Fluit AC, Hafner D Novak R (2003) Toxin-gene profile heterogeneity among endemic invasive European Group A streptococcal isolates. J Infect Dis 188 : 1578 1586. (Pubitemid 37523945)
20. Seppälä H, Nissinen A, Yu Q Huovinen P (1993) Three different phenotypes of erythromycin-resistant Streptococcus pyogenes in Finland. J Antimicrob Chemoth 32 : 885 891. (Pubitemid 24026589)
21. Silva-Costa C, Ramirez M Melo-Cristino J (2006) Identification of macrolide-resistant clones of Streptococcus pyogenes in Portugal. Clin Microbiol Infec 12 : 513 518. (Pubitemid 43740762)
22. Sriskandan S, Faulkner L Hopkins P (2007) Streptococcus pyogenes: insight into the function of the streptococcal superantigens. Int J Biochem Cell B 39 : 12 19. (Pubitemid 44548448)
23. Tenover FC, Arbeit RD, Goering RV, Mickelsen PA, Murray BE, Persing DH Swaminathan B (1995) Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strains typing. J Clin Microbiol 33 : 2233 2239.
24. Tsuda H, Yamashita Y, Shibata Y, Nakano Y Kogai T (2002) Genes involved in bacitracin resistance in Streptococcus mutans. Antimicrob Agents Ch 46 : 3756 3764. (Pubitemid 35403248)
25. York MK, Gibbs L, Perdreau-Remington F Brooks GF (1999) Characterization of antimicrobial resistance in Streptococcus pyogenes isolates from the San Francisco Bay Area of Northern California. J Clin Microbiol 37 : 1727 1731. (Pubitemid 29235214)