CXCR4 expression functionally discriminates centroblasts versus centrocytes within human germinal center B cells

Journal of Immunology

Volumn 182, Issue 12, 2009, Pages 7595-7602

  Caron, Gersende ^a,b   Le Gallou, Simon ^a   Lamy, Thierry ^a,b   Tarte, Karin ^a,b   Fest, Thierry ^a,b  

^a UNIVERSITÉ DE RENNES 1   (France)

^b PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; IMMUNOGLOBULIN; TRANSCRIPTION FACTOR; CERAMIDE TRIHEXOSIDE; GLOBOTRIAOSYLCERAMIDE; IMMUNOGLOBULIN G;

ARTICLE; B LYMPHOCYTE; BURKITT LYMPHOMA; CELL PROLIFERATION; CENTROBLAST; CENTROCYTE; GENE EXPRESSION REGULATION; GENE SEGREGATION; GERMINAL CENTER; HUMAN; HUMAN CELL; LYMPHOCYTE FUNCTION; LYMPHOCYTE STRUCTURE; MICROARRAY ANALYSIS; PHENOTYPE; PRIORITY JOURNAL; SOMATIC HYPERMUTATION; CELL CULTURE; CELL CYCLE; CELL DIFFERENTIATION; CELL MEMBRANE; CYTOLOGY; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; METABOLISM; SECRETION;

B-LYMPHOCYTES; CELL CYCLE; CELL DIFFERENTIATION; CELL MEMBRANE; CELLS, CULTURED; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GERMINAL CENTER; HUMANS; IMMUNOGLOBULIN G; RECEPTORS, CXCR4; TRANSCRIPTION, GENETIC; TRIHEXOSYLCERAMIDES;

EID: 67649204698     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0804272     Document Type: Article

References (27)

1. MacLennan, I. C. 1994. Germinal centers. Annu. Rev. Immunol. 12: 117-139.
2. Klein, U., and R. Dalla-Favera. 2008. Germinal centres: role in B-cell physiology and malignancy. Nat. Rev. Immunol. 8: 22-33.
3. Liu, Y. J., F. Malisan, O. de Bouteiller, C. Guret, S. Lebecque, J. Banchereau, F. C. Mills, E. E. Max, and H. Martinez-Valdez. 1996. Within germinal centers, isotype switching of immunoglobulin genes occurs after the onset of somatic mutation. Immunity 4: 241-250.
4. Pascual, V., Y. J. Liu, A. Magalski, O. de Bouteiller, J. Banchereau, and J. D. Capra. 1994. Analysis of somatic mutation in five B cell subsets of human tonsil. J. Exp. Med. 180: 329-339.
5. Högerkorp, C. M., and C. A. Borrebaeck. 2006. The human CD77-B cell population represents a heterogeneous subset of cells comprising centroblasts, centrocytes, and plasmablasts, prompting phenotypical revision. J. Immunol. 177: 4341-4349.
6. Klein, U., Y. Tu, G. A. Stolovitzky, J. L. Keller, J. Haddad, Jr., V. Miljkovic, G. Cattoretti, A. Califano, and R. Dalla-Favera. 2003. Transcriptional analysis of the B cell germinal center reaction. Proc. Natl. Acad. Sci. USA 100: 2639-2644.
7. Nakayama, Y., P. Stabach, S. E. Maher, M. C. Mahajan, P. Masiar, C. Liao, X. Zhang, Z. J. Ye, D. Tuck, A. L. Bothwell, et al. 2006. A limited number of genes are involved in the differentiation of germinal center B cells. J. Cell. Biochem. 99: 1308-1325.
8. van Galen, J. C., D. F. Dukers, C. Giroth, R. G. Sewalt, A. P. Otte, C. J. Meijer, and F. M. Raaphorst. 2004. Distinct expression patterns of polycomb oncoproteins and their binding partners during the germinal center reaction. Eur. J. Immunol. 34: 1870-1881.
9. Allen, C. D., K. M. Ansel, C. Low, R. Lesley, H. Tamamura, N. Fujii, and J. G. Cyster. 2004. Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5. Nat. Immunol. 5: 943-952.
10. Bende, R. J., F. van Maldegem, M. Triesscheijn, T. A. Wormhoudt, R. Guijt, and C. J. van Noesel. 2007. Germinal centers in human lymph nodes contain reactivated memory B cells. J. Exp. Med. 204: 2655-2665.
11. Hauser, A. E., T. Junt, T. R. Mempel, M. W. Sneddon, S. H. Kleinstein, S. E. Henrickson, U. H. von Andrian, M. J. Shlomchik, and A. M. Haberman. 2007. Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity 26: 655-667.
12. Hauser, A. E., M. J. Shlomchik, and A. M. Haberman. 2007. In vivo imaging studies shed light on germinal-centre development. Nat. Rev. Immunol. 7: 499-504.
13. Kelsoe, G. 1996. Life and death in germinal centers (redux). Immunity 4: 107-111.
14. Figge, M. T., A. Garin, M. Gunzer, M. Kosco-Vilbois, K. M. Toellner, and M. Meyer-Hermann. 2008. Deriving a germinal center lymphocyte migration model from two-photon data. J. Exp. Med. 205: 3019-3029.
15. Bohnhorst, J. O., M. B. Bjorgan, J. E. Thoen, J. B. Natvig, and K. M. Thompson. 2001. Bm1-Bm5 classification of peripheral blood B cells reveals circulating germinal center founder cells in healthy individuals and disturbance in the B cell subpopulations in patients with primary Sjögren's syndrome. J. Immunol. 167: 3610-3618.
16. Shapiro-Shelef, M., and K. Calame. 2005. Regulation of plasma-cell development. Nat. Rev. Immunol. 5: 230-242.
17. Teng, G., P. Hakimpour, P. Landgraf, A. Rice, T. Tuschl, R. Casellas, and F. N. Papavasiliou. 2008. MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Immunity 28: 621-629.
18. Cullen, B. R. 2004. Transcription and processing of human microRNA precursors. Mol. Cell 16: 861-865.
19. Neuberger, M. S., and C. Rada. 2007. Somatic hypermutation: activation-induced deaminase for C/G followed by polymerase eta for A/T. J. Exp. Med. 204: 7-10.
20. Dave, S. S., K. Fu, G. W. Wright, L. T. Lam, P. Kluin, E. J. Boerma, T. C. Greiner, D. D. Weisenburger, A. Rosenwald, G. Ott, et al. 2006. Molecular diagnosis of Burkitt's lymphoma. N. Engl. J. Med. 354: 2431-2442.
21. Hummel, M., S. Bentink, H. Berger, W. Klapper, S. Wessendorf, T. F. Barth, H. W. Bernd, S. B. Cogliatti, J. Dierlamm, A. C. Feller, et al. 2006. A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling. N. Engl. J. Med. 354: 2419-2430.
22. Subramanian, A., P. Tamayo, V. K. Mootha, S. Mukherjee, B. L. Ebert, M. A. Gillette, A. Paulovich, S. L. Pomeroy, T. R. Golub, E. S. Lander, and J. P. Mesirov. 2005. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc. Natl. Acad. Sci. USA 102: 15545-15550.
23. Allen, C. D., T. Okada, H. L. Tang, and J. G. Cyster. 2007. Imaging of germinal center selection events during affinity maturation. Science 315: 528-531.
24. Forster, R., E. Kremmer, A. Schubel, D. Breitfeld, A. Kleinschmidt, C. Nerl, G. Bernhardt, and M. Lipp. 1998. Intracellular and surface expression of the HIV-1 coreceptor CXCR4/fusin on various leukocyte subsets: rapid internalization and recycling upon activation. J. Immunol. 160: 1522-1531.
25. Cattoretti, G., R. Shaknovich, P. M. Smith, H. M. Jack, V. V. Murty, and B. Alobeid. 2006. Stages of germinal center transit are defined by B cell transcription factor coexpression and relative abundance. J. Immunol. 177: 6930-6939.
26. Raaphorst, F. M., F. J. van Kemenade, E. Fieret, K. M. Hamer, D. P. Satijn, A. P. Otte, and C. J. Meijer. 2000. Cutting edge: polycomb gene expression patterns reflect distinct B cell differentiation stages in human germinal centers. J. Immunol. 164: 1-4.
27. Feuillard, J., D. Taylor, M. Casamayor-Palleja, G. D. Johnson, and I. C. MacLennan. 1995. Isolation and characteristics of tonsil centroblasts with reference to Ig class switching. Int. Immunol. 7: 121-130.