Developmental delineation of metabolic-patterns of neonatal mice by using NMR-metabolic profiling on highly-diluted urine

Journal of Toxicological Sciences

Volumn 34, Issue 3, 2009, Pages 343-347

  Shimizu, Yusuke I ^a,b   Sunaga, Eri ^a   Aoyagi, Shun ^b   Kanazawa, Kenji ^a   Takahashi, Shigeru ^b   Takahashi, Yuji ^b   Nemoto, Tadashi ^a  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Diluted sample; Metabolic profiling; Mouse neonate; Newborn; PCA; Urine

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BODY FLUID; DEVELOPMENT; DILUTION; MALE; METABOLIC PROFILING; METABOLISM; METABOLITE; MOUSE; NEWBORN; NEWBORN PERIOD; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; RELIABILITY; STATISTICAL ANALYSIS; URINE;

ANIMALIA; MUS;

EID: 67649200145     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.34.343     Document Type: Article

References (9)

1. Beckonert, O., Keun, H.C., Ebbels, T.M., Bundy, J., Holmes, E., Lindon, J.C. and Nicholson, J.K. (2007): Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts. Nat. Protoc., 2, 2692-2703.
2. Bollard, M.E., Stanley, E.G., Lindon, J.C., Nicholson, J.K. and Holmes, E. (2005): NMR-based metabonomic approaches for evaluating physiological influences on biofluid composition. NMR Biomed., 18, 143-162.
3. Davis, C.D. and Milner, J. (2004): Frontiers in nutrigenomics, proteomics, metabolomics and cancer prevention. Mutat. Res., 551, 51-64.
4. Dohi, T., Nemoto, T., Ohta, S., Shitara, K., Hanai, N., Nudelman, E., Hakomori, S. and Oshima, M. (1993): Different binding properties of three monoclonal antibodies to sialyl Le(x) glycolipids in a gastric cancer cell line and normal stomach tissue. Anticancer Res., 13, 1277-1282.
5. 1H-NMR spectra of two hundred kinds of tea in the world. Anal. Sci., 22, 1307-1314.
6. 1H-NMR spectroscopy of urine. Anal. Sci., 21, 1259-1262.
7. Nemoto, T. (2008): Metabolic profiling with FT-NMR. In Advanced technology of metabolomics and its practical application (Fukusaki, E., ed.), pp.74-85, CMC Publishing Co., Tokyo. (In Japanese).
8. Nemoto, T., Ando, I., Kataoka, T., Arifuku, K., Kanazawa, K., Natori, Y. and Fujiwara, M. (2007): NMR metabolic profiling combined with two-step principal component analysis for toxin-induced diabetes model rat using urine. J. Toxicol. Sci., 32, 429-435.
9. Puiman, P. and Stoll, B. (2008): Animal models to study neonatal nutrition in humans. Curr. Opin. Clin. Nutr. Metab. Care, 11, 601-606.