Mechanisms of delayed wound healing by commonly used antiseptics

Journal of Trauma - Injury, Infection and Critical Care

Volumn 66, Issue 1, 2009, Pages 82-90

  Thomas, Gregory W ^a,b,c   Rael, Leonard T ^a,b,c   Bar Or, Raphael ^a,b,c   Shimonkevitz, Richard ^a,b   Mains, Charles W ^b   Slone, Denetta Sue ^a   Craun, Michael L ^d   Bar Or, David ^a,b,c  

^a SWEDISH MEDICAL CENTER   (United States)

^b St Anthony Central Hospital   (United States)

^c DMI BioSciences Inc   (United States)

^d SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

Author keywords

Antiseptics; Fibroblasts; Matrix metalloproteinase; Migration; Proliferation

Indexed keywords

ANTIINFECTIVE AGENT; CHLORHEXIDINE; HYDROGEN PEROXIDE; MATRIX METALLOPROTEINASE; POVIDONE IODINE; SULFADIAZINE SILVER; INTERSTITIAL COLLAGENASE; TOPICAL ANTIINFECTIVE AGENT;

ARTICLE; BACTERICIDAL ACTIVITY; CELL FUNCTION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DEBRIDEMENT; DOSE RESPONSE; ENZYME RELEASE; FIBROBLAST; HUMAN; HUMAN CELL; MEDICAL PHOTOGRAPHY; PRIORITY JOURNAL; WOUND HEALING; WOUND HEALING IMPAIRMENT; ZYMOGRAPHY; CELL MOTION; DRUG EFFECT; METABOLISM;

ANTI-INFECTIVE AGENTS, LOCAL; CELL MOVEMENT; CELL PROLIFERATION; CHLORHEXIDINE; FIBROBLASTS; HUMANS; HYDROGEN PEROXIDE; MATRIX METALLOPROTEINASE 1; POVIDONE-IODINE; SILVER SULFADIAZINE; WOUND HEALING;

EID: 67649194971     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e31818b146d     Document Type: Article

References (37)

1. Brem H, Stojadinovic O, Dieglmann RF, et al. Molecular markers in patients with chronic wounds to guide surgical debridement. Mol Med. 2007;13:30-39.
2. Howell-Jones RS, Wilson MJ, Hill KE, Howard AJ, Price PE, Thomas DW. A review of the microbiology, antibiotic usage and resistance in chronic skin wounds. J Antimicrob Chemother. 2005;55:143-149.
3. Harrington C, Zagari MJ, Corea J, Klitenic J. A cost analysis of diabetic lower-extremity ulcers. Diabetes Care. 2000;23:1333-1338.
4. Enoch S, Harding K. Wound bed preparation: the science behind the removal of barriers to healing (part 2). Wounds. 2003;15:213-229.
5. Drosou A, Falabella A, Kirsner RS. Antiseptics on wounds: and area of controversy (part 1). Wounds. 2003;15:149-166.
6. Cooper ML, Laxer JA, Hansbrough JF. The cytotoxic effects of commonly used topical antimicrobial agents on human fibroblasts and keratinocytes. J Trauma. 1991;31:782-784.
7. Wilson JR, Mills JG, Prather ID, Dimitrijevich SD. A toxicity index of skin and wound cleaners used on in vitro fibroblasts and keratinocytes. Adv Skin Wound Care. 2005;18:373-378.
8. McCauley RL, Linares HA, Pelligrini V, Herndon DN, Robson MC, Heggers JP. In vitro toxicity of topical antimicrobial agents to human fibroblasts. J Surg Res. 1989;46:267-274.
9. Damour O, Hua SZ, Lasne F, Villain M, Rousselle P, Collombel C. Cytotoxic evaluation of antiseptics and antibiotics on cultured human fibroblasts and keratinocytes. Burns. 1992;18:479-485.
10. Nodes CD, Hall A. Rho GTPase control polarity, protrusion, and adhesion during cell movement. J Cell Biol. 1999;144:1235-1244.
11. Mack RM, Cantrell JR. Quantitative studies of bacterial flora of open skin wounds: the effect of topical antibiotics. Ann Surg. 1967;166:886-895.
12. Lawrence RM, Hoeprich PD, Huston AC, Benson DR, Riggins RS. Quantitative microbiology of traumatic orthopedic wounds. J Clin Microbiol. 1978;8:673-675.
13. Bowler PG, Duerden BI, Armstrong DG. Wound microbiology and associated approaches to wound management. Clin Microbiol Rev. 2001;14:244-269.
14. Giacometti A, Cirioni O, Schimizzi AM, et al. Epidemiology and microbiology of surgical wound infections. J Clin Microbiol. 2000; 38:918-922.
15. Dowd SE, Sun Y, Secor PR, et al. Survey of bacterial diversity in chronic wounds using pyrosequencing, DGGE, and full ribosome shotgun sequencing. BMC Microbiol. 2008;8:43.
16. Trengrove NJ, Stacey MC, McGechie DF, Mata S. Qualitative bacteriology and leg ulcer healing. J Wound Care. 1996;5:277-280.
17. McDonnell G, Russell AD. Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev. 1999;12:147-179.
18. Elkins JG, Hassett DJ, Stewart PS, Schweizer HP, McDermott TR. Protective role of catatlase in Pseudomonas aeruginosa biofilm resistance to hydrogen peroxide. Appl Environ Microbiol. 1999; 65:4594-4600.
19. Presterl E, Suchomel M, Eder M, et al. Effects of alchohols, providone-iodine, and hydrogen peroxide on biofilms of Staphylococcus epidermidis. J Antimicrob Chemother. 2007;60:417-420.
20. Burks RI. Povidone-iodine solution in wound treatment. Phys Ther. 1998;78:212-218.
21. Shurrab MY. Antimicrobial efficiency of some antiseptic products on endodontic microflora isolated from gangrenous pulp tissue. J Contemp Dent Pract. 2006;7:53-62.
22. Brooks SE, Walczak MA, Hameed R, Coonan P. Chlorhexidine resistance in antibiotic-resistant bacteria isolated from the surfaces of dispensers of soap containing chlorhexidine. Infect Control Hosp Epidemiol. 2002;23:692-695.
23. Koljalg S, Naaber P, Mikelsaar M. Antibiotic resisitance as an indicator of bacterial chlorexidine susceptibilty. J Hosp Infect. 2002;51:106-113.
24. Spacciapoli P, Buxton D, Rothstein D, Friden P. Antimicrobial activity of silver nitrate against periodontal pathogens. J Periodontal Res. 2001;36:108-113.
25. Fox CL, Modak SM. Mechanism of silver sulfadiazine action on burn wound infection. Antimicrob Agents Chemother. 1974;5:582-588.
26. Bucalo B, Eaglstein WH, Falanga V. Inhibition of cell proliferation by chronic wound fluid. Wound Repair Regen. 1993;1:181-186.
27. Katz MH, Alverez AF, Kirsner RS, Eaglstein WH, Falanga V. Human wound fluid from acute wounds stimulates fibroblast and endothelial cell growth. J Am Acad Dermatol. 1991;26:1054-1058.
28. Mendez MV, Stanley A, Park HY, Shon K, Phillips T, Menzoian JO. Fibroblasts cultured from venous ulcers display cellular characteristics of senescence. J Vasc Surg. 1998;28:876-883.
29. Stanley AC, Park HY, Phillips TJ, Russakovsky V, Menzoian JO. Reduced growth of dermal fibroblasts from chronic venous ulcers can be stimulated with growth factors. J Vasc Surg. 1997;26:999-1001.
30. Vasquez R, Marien BJ, Gram C, Goodwin DG, Menzoian JO, Raffetto JD. Proliferative capacity of venous ulcer wound fibroblasts is the presence of platelet-derived growth factor. Vasc Endovascular Surg. 2004;38:355-360.
31. Broughton G II, Janis JE, Attinger CE. Wound healing: an overview. Plast Reconstr Surg. 2006;117(7 suppl):1e-S-32e-S.
32. Raffetto JD, Mendez MV, Marien BJ, et al. Changes in cellular motility and cytoskeletal actin in fibroblasts from patients with chronic venous insufficiency and in neonatal fibroblasts in the presence of chronic wound fluid. J Vasc Surg. 2001;33:1233-1241.
33. Broughton G II, Janis JE, Attinger CE. The basic science of wound healing. Plast Reconstr Surg. 2006;117(7 suppl):12S-34S.
34. Marneros AG, Olsen BR. The role of collagen-derived proteolytic fragments in angiogensis. Matrix Biol. 2001;5-6:337-345.
35. Nilsson UW, Dabrosin C. Estradiol and tamoxifen regulate endostatin generation via matrix metalloproteinase activity in breast cancer in vivo. Cancer Res. 2006;66:4789-4794.
36. Wlaschek M, Peus D, Acterberg V, Meyer-Ingold W, Scharffetter- Kochanek K. Protease inhibitors protect growth factor activity in chronic wounds. Br J Dermatol. 1997;137:646.
37. Wang M, Zhao D, Spinetti G, et al. Matrix metalloproteinase 2 activiation of transforming growth factor-beta1 (TGF-beta1) and TGF-beta1-type II receptor signaling within the aged arterial wall. Arterioscler Thromb Vasc Biol. 2006;26:1503-1509.