Dentin extracellular matrix molecules implanted into exposed pulps generate reparative dentin: A novel strategy in regenerative dentistry

Journal of Dental Research

Volumn 88, Issue 5, 2009, Pages 396-399

  Goldberg, M ^a   Six, N ^a   Chaussain, C ^a   DenBesten, P ^b   Veis, A ^c   Poliard, A ^a,d  

^a France   (France)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d INSERM   (France)

Author keywords

Amelogenins; Bone sialoprotein; MEPE; Pulp capping; Regenerative dentistry

Indexed keywords

AMELOGENIN; BIOMATERIAL; BONE SIALOPROTEIN; CALCIUM HYDROXIDE; CALCIUM PHOSPHATE; GLYCOPROTEIN; MEPE PROTEIN, RAT; PHOSPHOPROTEIN; SCLEROPROTEIN; SIALOGLYCOPROTEIN;

ANIMAL; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL MOTION; CELL PROLIFERATION; DENTIN; DENTISTRY; DRUG EFFECT; ENDODONTICS; METHODOLOGY; OSTEOBLAST; PHYSIOLOGY; RAT; REGENERATIVE MEDICINE; STEM CELL; TISSUE ENGINEERING; TOOTH PULP; TOOTH PULP DISEASE;

AMELOGENIN; ANIMALS; BIOCOMPATIBLE MATERIALS; CALCIUM HYDROXIDE; CALCIUM PHOSPHATES; CELL DIFFERENTIATION; CELL MOVEMENT; CELL PROLIFERATION; DENTAL PULP; DENTAL PULP CAPPING; DENTAL PULP EXPOSURE; DENTIN; DENTIN, SECONDARY; DENTISTRY; EXTRACELLULAR MATRIX PROTEINS; GLYCOPROTEINS; MODELS, ANIMAL; OSTEOBLASTS; PHOSPHOPROTEINS; RATS; REGENERATIVE MEDICINE; SIALOGLYCOPROTEINS; STEM CELLS; TISSUE ENGINEERING;

EID: 67649184798     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/0022034509337101     Document Type: Review

References (17)

1. Baume LJ (1980). The biology of pulp and dentin. In: Monographs in oral sciences. Myers HM, editor. Basel: Karger.
2. Bornstein P, Sage EH (2002). Matricellular proteins: extracellular modulators of cell functions. Curr Opin Cell Biol 14:606-616. (Pubitemid 35247745)
3. Decup F, Six N, Palmier B, Buch D, Lasfargues JJ, Salih E, et al. (2000). Bone sialoprotein-induced reparative dentinogenesis in the pulp of rat's molar. Clin Oral Investig 4:110-119.
4. Fitzgerald M, Chiego DJ, Heys DR (1990). Autoradiographic analysis of odontoblast replacement following pulp exposure in primate teeth. Arch Oral Biol 35:707-715.
5. Fujisawa K, Kuboki Y (1992). Affinity of bone sialoprotein and several other bone and dentin acidic proteins to collagen fibrils. Calcif Tissue Int 51:438-442.
6. Hunter GK, Goldberg HA (1993). Nucleation of hydroxyapatite by bone sialoprotein. Proc Natl Acad Sci USA 90:8562-8565.
7. Jegat N, Septier D, Veis A, Poliard A , Goldberg M (2007). Short-term effects of amelogenin gene splice products A+4 and A-4 implanted in the exposed rat molar pulp. Head Face Med 3:40.
8. Krüger A, Ellerström C, Lundmark C, Christersson C, Wurtz T (2002). RP59, a marker for osteoblast recruitment, is also detected in primitive mesenchymal cells, erythroid cells, and megakaryocytes. Dev Dyn 223:414-418. (Pubitemid 34203085)
9. Ohshima H (1990). Ultrastructural changes in odontoblasts and pulp capillaries following cavity preparation in rat molars. Arch Histol Cytol 53:423-438.
10. Oida S, Nagano T, Yamakoshi Y, Ando H, Yamada M, Fukae M (2002). Amelogenin gene expression in porcine odontoblasts. J Dent Res 81:103-108. (Pubitemid 41709790)
11. Qin C, Brunn JC, Cadena E, Ridall A, Tsujigiwa H, Nagatsuka H, et al. (2002). The expression of dentin sialophosphoprotein gene in bone. J Dent Res 81:392-394.
12. Schröder U (1985). Effects of calcium hydroxide-containing pulp capping agents on pulp cell migration, proliferation, and differentiation. J Dent Res 64(Spec Iss):541-548.
13. Six N, Tompkins K, Septier D, Veis A, Goldberg M (2004). Recruitment and characterization of the cells involved in reparative dentin formation in the exposed rat molar pulp after implantation of amelogenin gene splice products A+4 and A-4. Oral Biosci Med 1:35-44.
14. Six N, Septier D, Chaussain-Miller C, Blacher R, DenBesten P, Goldberg M (2007). Dentonin, a MEPE fragment, initiates pulp healing response to injury. J Dent Res 86:780-785.
15. Veis A (2003) Amelogenin gene splice products: potential signaling molecules. Cell Mol Life Sci 60:38-55.
16. Veis A, Tompkins K, Alvares K, Wei K, Wang L, Wang XS, et al. (2000). Specific amelogenin gene splice products have signaling effects on cell in culture and implant in vivo. J Biol Chem 275:41263-41272. (Pubitemid 32054960)
17. Wang J, Glimcher MJ, Mah J, Zhou HY, Salih E (1998). Expression of bone microsomal casein kinase II, bone sialoprotein, and osteopontin during the repair of calvarial defects. Bone 22:621-628. (Pubitemid 28284610)