Hemoglobin variability in chronic kidney disease: A cross-sectional study

American Journal of the Medical Sciences

Volumn 337, Issue 5, 2009, Pages 340-343

  Spiegel, David M ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Anemia management; Chronic kidney disease; Erythropoietin; ESAs; Hemodialysis

Indexed keywords

ANTIANEMIC AGENT; HEMOGLOBIN; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; RECOMBINANT ERYTHROPOIETIN; ERYTHROPOIETIN;

ANEMIA; ARTICLE; CHRONIC KIDNEY DISEASE; CROSS-SECTIONAL STUDY; DIALYSIS; HEMOGLOBIN BLOOD LEVEL; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; ALGORITHM; BLOOD; CHRONIC KIDNEY FAILURE; GLOMERULUS FILTRATION RATE; METABOLISM; METHODOLOGY; REFERENCE VALUE; REGRESSION ANALYSIS; RENAL REPLACEMENT THERAPY; SEASON; TIME;

ALGORITHMS; ANEMIA; CROSS-SECTIONAL STUDIES; ERYTHROPOIETIN; GLOMERULAR FILTRATION RATE; HEMATINICS; HEMOGLOBINS; HUMANS; KIDNEY FAILURE, CHRONIC; REFERENCE VALUES; REGRESSION ANALYSIS; RENAL DIALYSIS; SEASONS; TIME FACTORS;

EID: 67649112086     PISSN: 00029629     EISSN: None     Source Type: Journal    
DOI: 10.1097/MAJ.0b013e31818e5c08     Document Type: Article

References (22)

1. U.S. Renal Data System, USRDS. 2006 Annual Data Report: Atlas of end-stage renal disease in the United States. Bethesda (MD): National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; 2006.
2. National Kidney Foundation: K/DOQI clinical practice guidelines for anemia of chronic kidney disease: update 2000. Am J Kidney Dis 2001;37:S182-S238.
3. D'Ambra MN, Gray RJ, Hillman R, et al. Effect of recombinant human erythropoietin on transfusion risk in coronary bypass patients. Ann Thorac Surg 1997;64:1686-93.
4. Besarab A, Bolton WK, Browne JK, et al. The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin. N Engl J Med 1998;339: 584-90.
5. Singh AK, Szczech L, Tang KL, et al. Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med 2006;355: 2085-98.
6. Driïeke TB, Locatelli F, Clyne N, et al. Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med 2006;355:2071-84.
7. Henke M, Laszig R, Rube C, et al. Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomized, double-blind, placebo-controlled trial. Lancet 2003;362:1255-60.
8. Leyland-Jones B, Semiglazov V, Pawlicki M, et al. Maintaining normal hemoglobin levels with epoetin alfa in mainly nonanemic patients with metastatic breast cancer receiving first-line chemotherapy: a survival study. J Clin Oncol 2005;23:5960-72.
9. Bohlius J, Wilson J, Seidenfeld J, et al. Recombinant human erythropoietins and cancer patients: updated meta-analysis of 57 studies including 9353 patients. J Natl Cancer Inst 2006;98:708-714.
10. National Kidney Foundation: K/DOQI clinical practice guidelines for anemia of chronic kidney disease: 2007 update of hemoglobin target. Am J Kidney Dis 2007;50:476-530.
11. Jelkmann W. Molecular biology of erythropoietin. Intern Med 2004; 43:649-59.
12. Fisher JW. Erythropoietin: physiology and pharmacology update. Exp Biol Med 2003;228:1-14.
13. Collins AJ, Brenner RM, Ofman JJ, et al. Epoetin alfa use in patients with ESRD: an analysis of recent US prescribing patterns and hemoglobin outcomes. Am J Kidney Dis 2005;46:481-8.
14. Berns JS, Elzein H, Lynn RI, et al. Hemoglobin variability in epoetin-treated hemodialysis patients. Kidney Int 2003;64:1514-21.
15. Fishbane S, Berns JS. Hemoglobin cycling in hemodialysis patients treated with recombinant human erythropoietin. Kidney Int 2005;68: 1337-43.
16. West RM, Harris K, Gilthorpe MS, et al. Functional data analysis applied to a randomized controlled clinical trial in hemodialysis patients describes the variability of patient responses in the control of anemia. J Am Soc Nephrol 2007;18:2371-6.
17. Yang W, Israni RK, Brunelli SM, et al. Hemoglobin variability and mortality in ESRD. J Am Soc Nephrol 2007;18:3164-70.
18. Levey AS, Bosch JP, Lewis JB, et al. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Ann Intern Med 1999;130:461-70.
19. Dot D, Miro J, Fuentes-Arderiu X. Within-subject biological variation of hematological quantities and analytical goals. Arch Pathol Lab Med 1992;116:825-6.
20. Thirup P. Haematocrit: within-subject and seasonal variation. Sports Med 203;33:231-43.
21. Spiegel DM, Gitlin M, Mayne T. Factors affecting anemia management in hemodialysis patients: a single-center experience. Hemodialysis Int 2008;12:337-42.
22. Kalantar-Zadeh K, McAllister CJ, Lehn RS, et al. Effect of malnutrition-inflammation complex syndrome on EPO hyporesponsiveness in maintenance hemodialysis. Am J Kidney Dis 2003;42:761-73.