Functional data analysis applied to a randomized controlled clinical trial in hemodialysis patients describes the variability of patient responses in the control of renal anemia

Journal of the American Society of Nephrology

Volumn 18, Issue 8, 2007, Pages 2371-2376

  West, Robert M ^a   Harris, Katie ^a   Gilthorpe, Mark S ^a   Tolman, Cae ^b   Will, Eric J ^b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HEMOGLOBIN; NOVEL ERYTHROPOIESIS STIMULATING PROTEIN; RECOMBINANT ERYTHROPOIETIN;

ANEMIA; ARTICLE; CHRONIC KIDNEY FAILURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DATA ANALYSIS; DOSE RESPONSE; DRUG DOSE TITRATION; HEMODIALYSIS; HEMOGLOBIN BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VARIANCE; WAVEFORM;

EID: 34547635037     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2006050436     Document Type: Article

References (22)

1. Volkova N, Arab L: Evidence-based systematic literature review of hemoglobin/hematocrit and all-cause mortality in dialysis patients. Am J Kidney Dis 47: 24-36, 2006
2. Furuland H, Linde T, Ahlmen J, Christensson A, Strombom U, Danielson BG: A randomized controlled trial of haemoglobin normalization with epoetin alpha in pre-dialysis and dialysis patients. Nephrol Dial Transplant 18: 353-361, 2003
3. Moreno F, Sanz-Guajardo D, Lopez-Gomez JM, Jofre R, Valderrabano F: Increasing the hematocrit has a beneficial effect on quality of life and is safe in selected haemodialysis patients. Spanish Cooperative Renal Patients Quality of Life Study Group of the Spanish Society of Nephrology. J Am Soc Nephrol 11: 335-342, 2000
4. Treatment of Adults and Children with Renal Failure: Standards and Audit Measures, 3rd Ed., London, The Renal Association Royal College of Physicians of London, 2002
5. Locatelli F, Aljama P, Barany P, Canaud B, Carrera F, Eckardt KU, Horl WH, Macdougal IC, Macleod A, Wiecek A, Cameron S; European Best Practice Guidelines Working Group: Revised European Best Practice Guidelines for the management of anaemia in patients with chronic renal failure. Nephrol Dial Transplant 19[Suppl 7]: 1-47, 2004
6. Jacobs C, Frei D, Perkins AC: Results of the European survey on anaemia management 2003 (ESAM 2003): Current status of anaemia management in dialysis patients, factors affecting epoetin dosage and changes in anaemia management over the last 5 years. Nephrol Dial Transplant 20[Suppl 3]: iii3-iii24, 2005
7. Ebben JP, Gilbertson DT, Foley RN, Collins AJ: Hemoglobin level variability: Associations with co-morbidity, intercurrent events, and hospitalizations. Clin J Am Soc Nephrol 1: 1205-1210, 2006
8. Kaufman JS, Reda DJ, Fye CL, Goldfarb DS, Henderson WG, Kleinman JG, Vaamonde CA: Subcutaneous compared with intravenous epoetin in patients receiving hemodialysis. N Engl J Med 339: 578-583, 1998
9. Berns J, Fishbane S, Elzein H, Lynn RI, Deoreo DB, Tharpe DL, Meisels IS: The effect of a change in epoetin alfa reimbursement policy on anemia outcomes in hemodialysis patients. Hemodial Int 9: 255-263, 2005
10. Richardson D, Bartlett C, Will EJ: Intervention thresholds and ceilings can determine the haemoglobin outcome distribution in a haemodialysis population. Nephrol Dial Transplant 15: 2007-2013, 2000
11. Fishbane S, Berns JS: Hemoglobin cycling in hemodialysis patients treated with recombinant human erythropoietin. Kidney Int 68: 1337-1343, 2005
12. Patterson P, Allon M: Prospective evaluation of an anemia treatment algorithm in hemodialysis. Am J Kidney Dis 32: 635-641, 1998
13. Aiello J: Anemia management protocols and epoetin alpha administration: An algorithm approach. Nephrol Nurs J 29: 297-300, 2002
14. Brimble KS, Rabbat CG, McKenna P, Lambert K, Carlisle EJ: Protocolized anemia management with erythropoietin in hemodialysis patients: A randomized controlled trial. J Am Soc Nephrol 14: 2654-2661, 2003
15. Martin-Guerrero JD, Soria-Olivas E, Camps-Valls G, Serrano-Lopez AJ, Perez-Ruixo JJ, Jimenez-Torres NV: Use of neural networks for dosage individualization of erythropoietin patients with secondary anemia to chronic renal failure. Comput Biol Med 33: 361-373, 2003
16. Tolman C, Richardson D, Bartlett C, Will EJ: Structured conversion from thrice weekly to weekly erythropoietic regimens using a computerized decision-support system: A randomized clinical study. J Am Soc Nephrol 16: 1463-1470, 2005
17. Wiener N: Cybernetics or Control and Communication in the Animal and the Machine, 2nd Ed., Cambridge, MIT Press, 1961, pp 5-7
18. Richardson D, Bartlett C, Will EJ: Optimizing erythropoietin therapy in haemodialysis patients. Am J Kidney Dis 38: 109-117, 2001
19. Dierckx P: Curve and Surface Fitting with Splines. Oxford, Clarendon Press, 1993
20. O'Sullivan F: A statistical perspective on ill-posed inverse problems. Stat Sci 1: 505-527, 1986
21. Ramsay JO, Silverman BW: Functional Data Analysis, New York, Springer-Verlag, 1997
22. Hirsch MW, Smale S: Differential Equations, Dynamical Systems, and Linear Algebra, New York, Academic Press, 1974