The mitochondrial function was impaired in APP knockout mouse embryo fibroblast cells

Chinese Science Bulletin

Volumn 54, Issue 10, 2009, Pages 1725-1731

  Sheng, Baiyang ^a   Niu, Ying ^a   Zhou, Hui ^b   Yan, Jiaxin ^b   Zhao, Nanming ^a   Zhang, Xiufang ^a   Gong, Yandao ^a  

^a TSINGHUA UNIVERSITY   (China)

^b Wuhan Institute of Biological Products   (China)

Author keywords

Alzheimer's disease; Amyloid precursor protein (APP); Cytochrome c oxidase activity; Mitochondria; Mitochondrial membrane potential

Indexed keywords

EID: 67649094913     PISSN: 10016538     EISSN: 18619541     Source Type: Journal    
DOI: 10.1007/s11434-009-0239-7     Document Type: Article

References (17)

1. J. Kang H. G. Lemaire A. Unterbeck 1987 The precursor of Alzheimer's disease amyloid A4 protein resembles a cellsurface receptor Nature 325 733 736 (Pubitemid 17054046)
2. D. Goldgaber M. I. Lerman O. W. [tmp] McBride 1987 Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease Science 235 877 880 (Pubitemid 17019124)
3. Y. Chen B. L. Tang 2006 The amyloid precursor protein and postnatal neurogenesis/neuroregeneration Biochem Biophys Res Commun 341 1 1 5 (Pubitemid 43117377)
4. F. Magara U. Müller Z. W. Li 1999 Genetic background changes the pattern of forebrain commissure defects in transgenic mice underexpressing the beta amyloid-precursor protein Proc Natl Acad Sci USA 96 4656 4661 (Pubitemid 29190392)
5. H. Zheng M. Jiang M. E. Trumbauer 1995 Beta-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity Cell 81 525 531
6. Y. Hayashi K. Kashiwagi J. Ohta 1994 Alzheimer amyloid protein precursor enhances proliferation of neural stem cells from fetal rat brain Biochem Biophys Res Commun 205 1 936 943 (Pubitemid 24381716)
7. I. Ohsawa C. Takamura T. Morimoto 1999 Amino-terminal region of secreted form of amyloid precursor protein stimulates proliferation of neural stem cells Eur J Neurosci 11 6 1907 1913 (Pubitemid 29240555)
8. G. Kirfel B. Borm A. Rigort 2002 The secretory, beta-amyloid precursor protein is a motogen for human epidermal keratinocytes Eur J Cell Biol 81 664 676 (Pubitemid 36104762)
9. C. Siemes T. Quast C. Kummer 2006 Keratinocytes from APP/APLP2-deficient mice are impaired in proliferation, adhesion and migration in vitro Exp Cell Res 312 11 1939 1949 (Pubitemid 44183730)
10. P. Han F. Dou F. Li X. Zhang 2005 Suppression of cyclin-dependent kinase 5 activation by amyloid precursor protein: A novel excitoprotective mechanism involving modulation of tau phosphorylation J Neurosci 25 50 11542 11552 (Pubitemid 43098447)
11. F. Kamenetz T. Tomita H. Hsieh 2003 APP processing and synaptic function Neuron 37 925 937 (Pubitemid 36398299)
12. H. K. Anandatheerthavarada G. Biswas M. A. Robin 2003 Mitochondrial targeting and a novel transmembrane arrest of Alzheimer's amyloid precursor protein impairs mitochondrial function in neuronal cells J Cell Biol 161 41 54 (Pubitemid 36459078)
13. L. Devi B. M. Prabhu D. F. Galati 2006 Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction J Neurosci 26 35 9057 9068 (Pubitemid 44319397)
14. M. T. Lin M. F. Beal 2006 Alzheimer's APP mangles mitochondria Nat Med 12 11 1241 1243
15. C. Vijayasarathy S. Damle N. Lenka 1999 Tissue variant effects of heme inhibitors on the mouse Cytochrome c oxidase gene expression and catalytic activity of the enzyme complex Eur J Biochem 266 1 191 200
16. U. Keil A. Bonert C. A. Marques 2004 Amyloid β-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis J Biol Chem 279 48 50310 50320 (Pubitemid 39577847)
17. J. P. Fruehauf F. L. Meyskens Jr 2007 Reactive oxygen species: A breath of life or death? Clin Cancer Res 13 3 789 794 (Pubitemid 46340350)