메뉴 건너뛰기




Volumn 9, Issue 6, 2009, Pages 763-772

Insights into defibrotide: An updated review

Author keywords

Angiogenesis; Defibrotide; Endothelium; Neoplasia; Sinusoidal obstruction syndrome

Indexed keywords

ANTINEOPLASTIC AGENT; ANTITHROMBIN III; DEFIBROTIDE; GEMTUZUMAB OZOGAMICIN; GROWTH FACTOR; HEPARANASE; HEPARIN; MELPHALAN; PLACEBO; PREDNISONE; THALIDOMIDE; URSODEOXYCHOLIC ACID;

EID: 67649094520     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712590903008507     Document Type: Review
Times cited : (27)

References (73)
  • 2
    • 0027414593 scopus 로고
    • Defibrotide: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in vascular disorders
    • Palmer KJ, Goa KL. Defibrotide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in vascular disorders. Drugs 1993;45:259-294 (Pubitemid 23092629)
    • (1993) Drugs , vol.45 , Issue.2 , pp. 259-294
    • Palmer, K.J.1    Goa, K.L.2
  • 3
    • 0042527708 scopus 로고    scopus 로고
    • Defibrotide reduces procoagulant activity and increases fibrinolytic properties of endothelial cells
    • DOI 10.1038/sj.leu.2403004
    • Falanga A, Vignoli A, Marchetti M, Barbui T. Defibrotide reduces procoagulant activity and increases fibrinolytic properties of endothelial cells. Leukemia 2003;17:1636-1642 (Pubitemid 36986967)
    • (2003) Leukemia , vol.17 , Issue.8 , pp. 1636-1642
    • Falanga, A.1    Vignoli, A.2    Marchetti, M.3    Barbui, T.4
  • 5
    • 0023800090 scopus 로고
    • Acute effects of defibrotide, an experimental antithrombotic agent, on fibrinolysis and blood prostanoids in man
    • DOI 10.1007/BF00609244
    • Coccheri S, Biagi G, Legnani C, et al. Acute effects of defibrotide, an experimental antithrombotic agent, on fibrinolysis and blood prostanoids in man. Eur J Clin Pharmacol 1988;35:151-156 (Pubitemid 18223125)
    • (1988) European Journal of Clinical Pharmacology , vol.35 , Issue.2 , pp. 151-156
    • Coccheri, S.1    Biagi, G.2    Bianchini, B.3    Grauso, F.4
  • 7
    • 0028835345 scopus 로고
    • Isolation and functional characterization of DNA-derived aptamers that act as thrombin inhibitors in human platelets and coagulation assays
    • Bracht F, Schrör K. Isolation and functional characterization of DNA-derived aptamers that act as thrombin inhibitors in human platelets and coagulation assays. Agents Actions Suppl 1995;45:315-322
    • (1995) Agents Actions Suppl , vol.45 , pp. 315-322
    • Bracht, F.1    Schrör, K.2
  • 8
    • 0025001566 scopus 로고
    • Defibrotide, by enhancing prostacyclin generation, prevents endothelin-1 induced contraction in human saphenous veins
    • DOI 10.1016/0090-6980(90)90099-H
    • Berti F, Rossoni G, Biasi G, et al. Defibrotide, by enhancing prostacyclin generation, prevents endothelin-1 induced contraction in human saphenous veins. Prostaglandins 1990;40:337-350 (Pubitemid 20337225)
    • (1990) Prostaglandins , vol.40 , Issue.4 , pp. 337-350
    • Berti, F.1    Rossoni, G.2    Biasi, G.3    Buschi, A.4    Mandelli, V.5    Tondo, C.6
  • 9
    • 0028199746 scopus 로고
    • Defibrotide stimulates expression of thrombomodulin in human endothelial cells
    • Zhou Q, Chu X, Ruan C. Defibrotide stimulates expression of thrombomodulin in human endothelial cells. Thromb Haemost 1994;71:507-510 (Pubitemid 24100679)
    • (1994) Thrombosis and Haemostasis , vol.71 , Issue.4 , pp. 507-510
    • Zhou, Q.1    Chu, X.2    Ruan, C.3
  • 10
    • 0032966183 scopus 로고    scopus 로고
    • Hepatic stellate cells (Ito cells) in veno-occlusive disease of the liver after allogeneic bone marrow transplantation
    • DOI 10.1046/j.1365-2559.1999.00569.x
    • Sato Y, Asada Y, Hara S, et al. Hepatic stellate cells (Ito cells) in veno-occlusive disease of the liver after allogeneic bone marrow transplantation. Histopathology 1999;34:66-70 (Pubitemid 29049079)
    • (1999) Histopathology , vol.34 , Issue.1 , pp. 66-70
    • Sato, Y.1    Asada, Y.2    Hara, S.3    Marutsuka, K.4    Tamura, K.5    Hayashi, T.6    Sumiyoshi, A.7
  • 11
    • 0026715878 scopus 로고
    • Defibrotide inhibits platelet activation by cathepsin G released from stimulated polymorphonuclear leukocytes
    • Evangelista V, Piccardoni P, de Gaetano G, Cerletti C. Defibrotide inhibits platelet activation by cathepsin G released from stimulated polymorphonuclear leukocytes. Thromb Haemost 1992;67:660-664
    • (1992) Thromb Haemost , vol.67 , pp. 660-664
    • Evangelista, V.1    Piccardoni, P.2    De Gaetano, G.3    Cerletti, C.4
  • 12
    • 0036659926 scopus 로고    scopus 로고
    • Fludarabine induces apoptosis, activation, and allogenicity in human endothelial and epithelial cells: Protective effect of defibrotide
    • DOI 10.1182/blood.V100.1.334
    • Eissner G, Multhoff G, Gerbitz A, et al. Fludarabine induces apoptosis, activation, and allogenicity in human endothelial and epithelial cells: protective effect of defibrotide. Blood 2002;100:334-340 (Pubitemid 35177465)
    • (2002) Blood , vol.100 , Issue.1 , pp. 334-340
    • Eissner, G.1    Multhoff, G.2    Gerbitz, A.3    Kirchner, S.4    Bauer, S.5    Haffner, S.6    Sondermann, D.7    Andreesen, R.8    Holler, E.9
  • 13
    • 58149163610 scopus 로고    scopus 로고
    • Angiogenesis alteration by defibrotide: Implications for its mechanism of action in severe hepatic veno-occlusive disease
    • Benimetskaya L, Wu S, Voskresenskiy AM, et al. Angiogenesis alteration by defibrotide: implications for its mechanism of action in severe hepatic veno-occlusive disease. Blood 2008;112:4343-4352
    • (2008) Blood , vol.112 , pp. 4343-4352
    • Benimetskaya, L.1    Wu, S.2    Voskresenskiy, A.M.3
  • 16
    • 0025610352 scopus 로고
    • The prevention of deep venous thromboses after radical or modified mastectomy interventions
    • Interdonato F, Festi L, Gerosa C, et al. The prevention of deep venous thromboses after radical or modified mastectomy interventions. Minerva Chir 1990;45:1389-1392
    • (1990) Minerva Chir , vol.45 , pp. 1389-1392
    • Interdonato, F.1    Festi, L.2    Gerosa, C.3
  • 17
    • 0023267296 scopus 로고
    • Prevention of deep venous thrombosis with defibrotide in chest surgery. Controlled multicenter study versus heparin
    • Rizzi A, Radaelli F, Pisano M, et al. Prevention of deep venous thrombosis with defibrotide in chest surgery. Controlled multicenter study versus heparin. Minerva Med 1987;78:745-750
    • (1987) Minerva Med , vol.78 , pp. 745-750
    • Rizzi, A.1    Radaelli, F.2    Pisano, M.3
  • 18
    • 0025094789 scopus 로고
    • And heparin in the prevention of deep venous thromboses. A controlled study
    • Villani LG, Dalla Valle R, Rubini P. Defibrotide and heparin in the prevention of deep venous thromboses. A controlled study. Minerva Chir 1990;45:1029-1033
    • (1990) Minerva Chir , vol.45 , pp. 1029-1033
    • Villani, L.G.1    Dalla Valle, R.2    Defibrotide, R.P.3
  • 20
    • 0022887149 scopus 로고
    • Effective of defibrotide for prophylaxis of deep venous thrombosis in gynecological surgery: A double-blind, placebo-controlled clinical trial
    • Ciavarella N, Ettorre C, Schiavoni M, et al. Effectiveness of defibrotide for prophylaxis of deep venous thrombosis in gynecological surgery: a double-blind, placebo-controlled clinical trial. Haemostasis 1986;16(suppl 1):39-41 (Pubitemid 16069987)
    • (1986) Haemostasis , vol.16 , Issue.SUPPL. 1 , pp. 39-41
    • Ciavarella, N.1    Ettore, C.2    Schiavoni, M.3
  • 25
    • 0034018994 scopus 로고    scopus 로고
    • Improvement of walking distance by defibrotide in patients with intermittent claudication. Results of a randomized, placebo-controlled study (the DICLIS study)
    • Violi F, Marubini E, Coccheri S, Nenci GG. Improvement of walking distance by defibrotide in patients with intermittent claudication - results of a randomized, placebo controlled study (the DICLIS study). Defibrotide Intermittent Claudication Italian Study. Thromb Haemost 2000;83:672-677 (Pubitemid 30248512)
    • (2000) Thrombosis and Haemostasis , vol.83 , Issue.5 , pp. 672-677
    • Violi, F.1    Marubini, E.2    Coccheri, S.3    Nenci, G.G.4
  • 26
    • 0036732005 scopus 로고    scopus 로고
    • Treatment of catastrophic antiphospholipid syndrome with defibrotide, a proposed vascular endothelial cell modulator
    • Burcoglu-O'Ral A, Erkan D, Asherson R. Treatment of catastrophic antiphospholipid syndrome with defibrotide, a proposed vascular endothelial cell modulator. J Rheumatol 2002;29:2006-2011 (Pubitemid 34988713)
    • (2002) Journal of Rheumatology , vol.29 , Issue.9 , pp. 2006-2011
    • Burcoglu-O'Ral, A.1    Erkan, D.2    Asherson, R.3
  • 29
    • 67649133693 scopus 로고    scopus 로고
    • Thrombotic microangiopathy after mllogeneic stem cell transplantation: A single centre experience
    • abstract
    • Ngirabacu MC, Kwan J, Leroy R, et al. Thrombotic microangiopathy after mllogeneic stem cell transplantation: a single centre experience [abstract]. Blood 2007;110:1669
    • (2007) Blood , vol.110 , pp. 1669
    • Ngirabacu, M.C.1    Kwan, J.2    Leroy, R.3
  • 30
    • 0029011780 scopus 로고
    • The syndrome of hepatic veno-occlusive disease after bone marrow transplantation
    • Bearman SI. The syndrome of hepatic veno-occlusive disease after bone marrow transplantation. Blood 1995;85:3005-3020
    • (1995) Blood , vol.85 , pp. 3005-3020
    • Bearman, S.I.1
  • 32
    • 0034823905 scopus 로고    scopus 로고
    • Hepatic veno-occlusive disease following hematopoietic stem cell transplantation
    • DOI 10.1159/000046590
    • Richardson PG, Guinana EC. Hepatic veno occlusive disease following hematopoietic stem cell transplantation. Acta Hematologica 2001;106:57-68 (Pubitemid 32830517)
    • (2001) Acta Haematologica , vol.106 , Issue.1-2 , pp. 57-68
    • Richardson, P.1    Guinan, E.2
  • 33
    • 34249934790 scopus 로고    scopus 로고
    • Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: Review and update on the use of defibrotide and other current investigational therapies
    • Ho VT, Linden E, Revta C, Richardson PG. Hepatic veno-occlusive disease after hematopoietic stem cell transplantation: review and update on the use of defibrotide and other current investigational therapies. Semin Thromb Hemost 2007;33:373-388
    • (2007) Semin Thromb Hemost , vol.33 , pp. 373-388
    • Ho, V.T.1    Linden, E.2    Revta, C.3    Richardson, P.G.4
  • 34
    • 17344395285 scopus 로고    scopus 로고
    • Tumor cell prothrombotic properties
    • Falanga A. Tumor cell prothrombotic properties. Haemostasis 2001;31(suppl 1):1-4
    • (2001) Haemostasis , vol.31 , Issue.SUPPL. 1 , pp. 1-4
    • Falanga, A.1
  • 36
    • 33846272384 scopus 로고    scopus 로고
    • Systematic Review of Controlled Clinical Trials on the Use of Ursodeoxycholic Acid for the Prevention of Hepatic Veno-occlusive Disease in Hematopoietic Stem Cell Transplantation
    • DOI 10.1016/j.bbmt.2006.09.012, PII S1083879106006689
    • Tay J, Tinmouth A, Fergusson D, et al. Systematic review of controlled clinical trials on the use of ursodeoxycholic acid for the prevention of hepatic veno-occlusive disease in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2007;13:206-217 (Pubitemid 46115719)
    • (2007) Biology of Blood and Marrow Transplantation , vol.13 , Issue.2 , pp. 206-217
    • Tay, J.1    Tinmouth, A.2    Fergusson, D.3    Huebsch, L.4    Allan, D.S.5
  • 38
    • 1842336845 scopus 로고    scopus 로고
    • Treatment of hepatic venocclusive disease with recombinant human tissue plasminogen activator and heparin in 42 marrow transplant patients
    • Bearman SI, Lee JL, Baron AE, McDonald GB. Treatment of hepatic venoocclusive disease with recombinant human issue plasminogen activator and heparin in 42 marrow transplant patients. Blood 1997;89:1501-1506 (Pubitemid 27097440)
    • (1997) Blood , vol.89 , Issue.5 , pp. 1501-1506
    • Bearman, S.I.1    Lee, J.L.2    Baron, A.E.3    McDonald, G.B.4
  • 43
    • 21344435666 scopus 로고    scopus 로고
    • Defibrotide (Df ) for the treatment of severe veno-occlusive disease (VOD) and multi-organ failure (MOF) post SCT: Final results of a phase II, multicenter, randomized study and preliminary analyses of surrogate markers and ultrasound findings
    • abstract
    • Richardson P, Soiffer R, Antin JH, et al. Defibrotide (Df ) for the treatment of severe veno-occlusive disease (VOD) and multi-organ failure (MOF) post SCT: final results of a phase II, multicenter, randomized study and preliminary analyses of surrogate markers and ultrasound findings [abstract]. Blood 2004;104:350
    • (2004) Blood , vol.104 , pp. 350
    • Richardson, P.1    Soiffer, R.2    Antin, J.H.3
  • 44
    • 33751522285 scopus 로고    scopus 로고
    • Incidence and management of hepatic veno-occlusive disease in 237 patients undergoing reduced-intensity conditioning (RIC) haematopoietic stem cell transplantation (HSCT)
    • Ramasamy K, Lim ZY, Pagliuca A, et al. Incidence and management of hepatic veno-occlusive disease in 237 patients undergoing reduced-intensity conditioning (RIC) haematopoietic stem cell transplantation (HSCT). Bone Marrow Transplant 2006;38:823-824
    • (2006) Bone Marrow Transplant , vol.38 , pp. 823-824
    • Ramasamy, K.1    Lim, Z.Y.2    Pagliuca, A.3
  • 46
    • 34248187052 scopus 로고    scopus 로고
    • Defibrotide for the treatment of hepatic veno-occlusive disease in children
    • DOI 10.1002/pbc.20934
    • Bulley SR, Strahm B, Doyle J, Dupuis LL. Defibrotide for the treatment of hepatic venoocclusive disease in children. Pediatr Blood Cancer 2007;48:700-704 (Pubitemid 46717618)
    • (2007) Pediatric Blood and Cancer , vol.48 , Issue.7 , pp. 700-704
    • Bulley, S.R.1    Strahm, B.2    Doyle, J.3    Dupuis, L.L.4
  • 47
    • 33745751942 scopus 로고    scopus 로고
    • Hepatic veno-occlusive disease in pediatric stem cell transplantation: Impact of pre-emptive antithrombin III replacement and combined antithrombin III/defibrotide therapy
    • Haussmann U, Fischer J, Eber S, et al. Hepatic veno-occlusive disease in pediatric stem cell transplantation: impact of pre-emptive antithrombin III replacement and combined antithrombin III/defibrotide therapy. Haematologica 2006;91:795-800 (Pubitemid 44014546)
    • (2006) Haematologica , vol.91 , Issue.6 , pp. 795-800
    • Haussmann, U.1    Fischer, J.2    Eber, S.3    Scherer, F.4    Seger, R.5    Gungor, T.6
  • 48
    • 77953617891 scopus 로고    scopus 로고
    • Defibrotide for the treatment of veno-occlusive disease post SCT: Preliminary results of EU compassionate use program in 332 patients confirm promising activity and manageable toxicity
    • abstract
    • Carreras E, Olavarria E, Neven B, et al. Defibrotide for the treatment of veno-occlusive disease post SCT: preliminary results of EU compassionate use program in 332 patients confirm promising activity and manageable toxicity [abstract]. Blood 2007;110:613
    • (2007) Blood , vol.110 , pp. 613
    • Carreras, E.1    Olavarria, E.2    Neven, B.3
  • 49
    • 67649095028 scopus 로고    scopus 로고
    • A Phase 3 randomized, historically-controlled clinical trial investigating the use of defibrotide in the treatment of severe veno-occlusive disease post-SCT: A novel approach to the validation of a promising new drug for the treatment of a life threatening disease
    • abstract
    • Richardson P, Kernan N, Tomblyn M, et al. A Phase 3 randomized, historically-controlled clinical trial investigating the use of defibrotide in the treatment of severe veno-occlusive disease post-SCT: a novel approach to the validation of a promising new drug for the treatment of a life threatening disease [abstract]. Blood 2007;110(11):614
    • (2007) Blood , vol.110 , Issue.11 , pp. 614
    • Richardson, P.1    Kernan, N.2    Tomblyn, M.3
  • 52
    • 1442307426 scopus 로고    scopus 로고
    • Prophylaxis with defibrotide prevents veno-occlusive disease in stem cell transplantation after gemtuzumab ozogamicin exposure [3]
    • DOI 10.1182/blood-2003-10-3612
    • Versluys B, Bhattacharaya R, Steward C, et al. Prophylaxis with defibrotide prevents veno-occlusive disease in stem cell transplantation after gemtuzumab ozogamicin exposure. Blood 2004;103:1968 (Pubitemid 38269002)
    • (2004) Blood , vol.103 , Issue.5 , pp. 1968
    • Versluys, B.1    Bhattacharaya, R.2    Steward, C.3    Comish, J.4    Oakhill, A.5    Goulden, N.6
  • 53
    • 33749443746 scopus 로고    scopus 로고
    • Stem cell transplantation in children with infantile osteopetrosis is associated with a high incidence of VOD, which could be prevented with defibrotide
    • DOI 10.1038/sj.bmt.1705485, PII 1705485
    • Corbacioglu S, Honig M, Lahr G, et al. Stem cell transplantation in children with infantile osteopetrosis is associated with a high incidence of VOD, which could be prevented with defibrotide. Bone Marrow Transplant 2006;38:547-553 (Pubitemid 44509547)
    • (2006) Bone Marrow Transplantation , vol.38 , Issue.8 , pp. 547-553
    • Corbacioglu, S.1    Honig, M.2    Lahr, G.3    Stohr, S.4    Berry, G.5    Friedrich, W.6    Schulz, A.S.7
  • 54
    • 34347407602 scopus 로고    scopus 로고
    • Prophylactic defibrotide in allogeneic stem cell transplantation: Minimal morbidity and zero mortality from veno-occlusive disease
    • DOI 10.1038/sj.bmt.1705696, PII 1705696
    • Dignan F, Gujral D, Ethell M, et al. Prophylactic defibrotide in allogeneic stem cell transplantation: minimal morbidity and zero mortality from veno-occlusive disease. Bone Marrow Transplant 2007;40:79-82 (Pubitemid 47018417)
    • (2007) Bone Marrow Transplantation , vol.40 , Issue.1 , pp. 79-82
    • Dignan, F.1    Gujral, D.2    Ethell, M.3    Evans, S.4    Treleaven, J.5    Morgan, G.6    Potter, M.7
  • 56
    • 67649084576 scopus 로고    scopus 로고
    • Defibrotide low-dose continuous infusion from day + 1 until day + 21 after allogeneic stem cell transplantation as prophylaxis of veno-occlusive disease (VOD) of the liver. A single centre experience
    • abstract
    • Bonini A, Avanzini P, Masini L, et al. Defibrotide low-dose continuous infusion from day + 1 until day + 21 after allogeneic stem cell transplantation as prophylaxis of veno-occlusive disease (VOD) of the liver. A single centre experience [abstract]. Blood 2007;110(11):4927
    • (2007) Blood , vol.110 , Issue.11 , pp. 4927
    • Bonini, A.1    Avanzini, P.2    Masini, L.3
  • 57
    • 67649133692 scopus 로고    scopus 로고
    • Defibrotide in prevention of liver toxicity in patients at high risk of VOD after HSC transplantation
    • abstract
    • Milone G, Poidomani M, Coppoletta S, et al. Defibrotide in prevention of liver toxicity in patients at high risk of VOD after HSC transplantation [abstract]. Blood 2008;112(11):3275
    • (2008) Blood , vol.112 , Issue.11 , pp. 3275
    • Milone, G.1    Poidomani, M.2    Coppoletta, S.3
  • 58
    • 67649131105 scopus 로고    scopus 로고
    • Optimal thalassemia free survival and minimal regimen related toxicity in 50 consecutive transplants of high risk beta thalassemia pediatric patients using myelablative therapy with intravenous busulphan
    • abstract
    • Marktel S, Chiesa R, Cappelli B, et al. Optimal thalassemia free survival and minimal regimen related toxicity in 50 consecutive transplants of high risk beta thalassemia pediatric patients using myelablative therapy with intravenous busulphan [abstract]. Blood 2008;112(11):3266
    • (2008) Blood , vol.112 , Issue.11 , pp. 3266
    • Marktel, S.1    Chiesa, R.2    Cappelli, B.3
  • 59
  • 61
  • 63
    • 36749069842 scopus 로고    scopus 로고
    • From the bench to the bedside: Emerging new treatments in multiple myeloma
    • DOI 10.1016/j.beha.2007.09.008, PII S1521692607000746, New Insights into the Biology and Advances in the Management of Multiple Myeloma
    • Mitsiades CS, Hayden PJ, Anderson KC, Richardson PG. From the bench to the bedside: emerging new treatments in multiple myeloma. Best Pract Res Clin Haematol 2007;20:797-816 (Pubitemid 350215385)
    • (2007) Best Practice and Research in Clinical Haematology , vol.20 , Issue.4 , pp. 797-816
    • Mitsiades, C.S.1    Hayden, P.J.2    Anderson, K.C.3    Richardson, P.G.4
  • 64
    • 36749036111 scopus 로고    scopus 로고
    • Defibrotide targets tumor micronevironmental interaction and sensitizes multiple myeloma and solid tumor cells to cytotoxic chemotherapy
    • abstract
    • Mitsiades CS, Rouleau C, Menon K, et al. Defibrotide targets tumor micronevironmental interaction and sensitizes multiple myeloma and solid tumor cells to cytotoxic chemotherapy [abstract]. Blood (ASH) 2004;104:286
    • (2004) Blood (ASH) , vol.104 , pp. 286
    • Mitsiades, C.S.1    Rouleau, C.2    Menon, K.3
  • 65
    • 34848853358 scopus 로고    scopus 로고
    • Defibrotide, an orally bioavailable modulator of myeloma tumor microenvironment interactions: Molecular sequelae and clinical implications
    • abstract
    • Mitsiades CS, Benimetskaya L, Menon K, et al. Defibrotide, an orally bioavailable modulator of myeloma tumor microenvironment interactions: molecular sequelae and clinical implications [abstract]. Blood (ASH) 2006;108:3523
    • (2006) Blood (ASH) , vol.108 , pp. 3523
    • Mitsiades, C.S.1    Benimetskaya, L.2    Menon, K.3
  • 66
    • 47949127951 scopus 로고    scopus 로고
    • Defibrotide induces downregulation of heparanase expression in multiple myeloma cell lines: A novel mechanism of action
    • Echart C, Distaso M, Ferro L, et al. Defibrotide induces downregulation of heparanase expression in multiple myeloma cell lines: a novel mechanism of action. Haematologica 2007;92(suppl 2):146
    • (2007) Haematologica , vol.92 , Issue.SUPPL. 2 , pp. 146
    • Echart, C.1    Distaso, M.2    Ferro, L.3
  • 67
    • 63149153926 scopus 로고    scopus 로고
    • Preclinical studies in support of defibrotide for the treatment of multiple myeloma and other neoplasias
    • Mitsiades CS, Rouleau C, Echart C, et al. Preclinical studies in support of defibrotide for the treatment of multiple myeloma and other neoplasias. Clin Cancer Res 2009;15:1210-1221
    • (2009) Clin Cancer Res , vol.15 , pp. 1210-1221
    • Mitsiades, C.S.1    Rouleau, C.2    Echart, C.3
  • 68
    • 67649106267 scopus 로고    scopus 로고
    • Defibrotide counteracts the modifications of antithrombotic phenotype of endothelial cells induced by thalidomide
    • abstract
    • Echart C, Graziadio B, Repice C, et al. Defibrotide counteracts the modifications of antithrombotic phenotype of endothelial cells induced by thalidomide [abstract]. Blood 2007;110(11):2502
    • (2007) Blood , vol.110 , Issue.11 , pp. 2502
    • Echart, C.1    Graziadio, B.2    Repice, C.3
  • 69
    • 67649102272 scopus 로고    scopus 로고
    • A Phase I/II trial on melphalan, prednisone, thalidomide, defibrotide combination in relapsed/refractory multiple myeloma patients
    • abstract
    • Palumbo A, Larocca A, Rus C, et al. A Phase I/II trial on melphalan, prednisone, thalidomide, defibrotide combination in relapsed/refractory multiple myeloma patients [abstract]. Blood 2007;110(11):2715
    • (2007) Blood , vol.110 , Issue.11 , pp. 2715
    • Palumbo, A.1    Larocca, A.2    Rus, C.3
  • 70
    • 0023711089 scopus 로고
    • Defibrotide in the prevention of deep venous thrombosis in general surgery. Preliminary results of a multicenter study
    • Ferrari PA, Cornelli U, Dina F, et al. Defibrotide in the prevention of deep venous thrombosis in general surgery. Preliminary results of a multicenter study. Minerva Med 1988;79:551-561
    • (1988) Minerva Med , vol.79 , pp. 551-561
    • Ferrari, P.A.1    Cornelli, U.2    Dina, F.3
  • 71
    • 0023936170 scopus 로고
    • Clinical pharmacology and mode of action of a new antithrombotic compound: Defibrotide
    • Ulutin ON, Cizmeci G, Balkuv-Ulutin S. Clinical pharmacology and mode of action of a new antithrombotic compound: defibrotide. Folia Haematol Int Mag Klin Morphol Blutforsch 1988;115:177-180 (Pubitemid 18156479)
    • (1988) Folia Haematologica , vol.115 , Issue.1-2 , pp. 177-180
    • Ulutin, O.N.1    Cizmeci, G.2    Balkuv-Ulutin, S.3
  • 72
    • 0026321693 scopus 로고
    • Pharmacokinetics of defibrotide in uremic patients undergoing hemodialysis
    • Rossi R, Farma A, Maggi GC, Marelli A. Pharmacokinetics of defibrotide in uremic patients undergoing hemodialysis. Minerva Med 1991;82:853-857
    • (1991) Minerva Med , vol.82 , pp. 853-857
    • Rossi, R.1    Farma, A.2    Maggi, G.C.3    Marelli, A.4
  • 73
    • 40449123709 scopus 로고    scopus 로고
    • Defibrotide in the prevention and treatment of veno-occlusive disease in autologous and allogeneic stem cell transplantation in children
    • DOI 10.1002/pbc.21425
    • Qureshi A, Marshall L, Lancaster D. Defibrotide in the prevention and treatment of veno-occlusive disease in autologous and allogeneic stem cell transplantation in children. Pediatr Blood Cancer 2008;50:831-832 (Pubitemid 351354794)
    • (2008) Pediatric Blood and Cancer , vol.50 , Issue.4 , pp. 831-832
    • Qureshi, A.1    Marshall, L.2    Lancaster, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.