Respective contribution exerted by AF-1 and AF-2 transactivation functions in estrogen receptor α induced transcriptional activity by isoflavones and equol: Consequence on breast cancer cell proliferation

Molecular Nutrition and Food Research

Volumn 53, Issue 5, 2009, Pages 652-658

  Carreau, Charlotte ^a   Flouriot, Gilles ^b   Bennetau Pelissero, Catherine ^a   Potier, Mylène ^a  

^a ENITA de Bordeaux   (France)

^b Equipe 'Récepteur des strogènes et destinée cellulaire' CNRS UMR 6026   (France)

Author keywords

Breast cancer; Cellular background; Estrogen receptor; Phytoestrogens; Transactivation functions

Indexed keywords

GLYCINE MAX;

EID: 67649090503     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.200800061     Document Type: Article

References (26)

1. Althuis, M. D., Dozier, J. M., Anderson, W. F., Devesa, S. S., Brinton, L. A., Global trends in breast cancer incidence and mortality 1973-1997, Int. J. Epidemiol. 2005, 34, 405-412.
2. Setchell, K. D., Cassidy, A., Dietary isoflavones: Biological effects and relevance to human health, J. Nutr. 1999, 129, 758S-767S.
3. Kuiper, G. G., Lemmen, J. G., Carlsson, B., Corton, J. C. et al., Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor beta, Endocrinology 1998, 139, 4252-4263.
4. Rice, S., Whitehead, S. A., Phytoestrogens, oestrogen synthesis and breast cancer, J. Steroid Biochem. Mol. Biol. 2008, 108, 186-195.
5. Ali, S., Metzger, D., Bornert, J. M., Chambon, P., Modulation of transcriptional activation by ligand-dependent phosphorylation of the human oestrogen receptor A/B region EMBO J. 1993, 12, 1153-1160.
6. Metivier, R., Penot, G., Flouriot, G., Pakdel, F., Synergism between ERalpha transactivation function 1 (AF-1) and AF-2 mediated by steroid receptor coactivator protein-1: Requirement for the AF-1 alpha-helical core and for a direct interaction between the N- and C-terminal domains, Mol. Endocrinol. 2001, 15, 1953-1970.
7. Berry, M., Metzger, D., Chambon, P., Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the antioestrogen 4-hydroxytamoxifen, EMBO J. 1990, 9, 2811-2818.
8. Tzukerman, M. T., Esty, A., Santiso-Mere, D., Danielian, P. et al., Human estrogen receptor transactivational capacity is determined by both cellular and promoter context and mediated by two functionally distinct intramolecular regions, Mol. Endocrinol. 1994, 8, 21-30.
9. Merot, Y., Metivier, R., Penot, G., Manu, D. et al., The relative contribution exerted by AF-1 and AF-2 transactivation functions in estrogen receptor alpha transcriptional activity depends upon the differentiation stage of the cell, J. Biol. Chem. 2004, 279, 26184-26191.
10. Huet, G., Merot, Y., Le Dily, F., Kern, L. et al., Loss of E-cadherin-mediated cell contacts reduces estrogen receptor alpha (ER alpha) transcriptional efficiency by affecting the respective contribution exerted by AF1 and AF2 transactivation functions, Biochem. Biophys. Res. Commun. 2008, 365, 304-309.
11. Potier, M., Elliot, S. J., Tack, I., Lenz, O. et al., Expression and regulation of estrogen receptors in mesangial cells: Influence on matrix metalloproteinase-9, J. Am. Soc. Nephrol. 2001, 12, 241-251.
12. Lampe, J. W., Isoflavonoid and lignan phytoestrogens as dietary biomarkers, J. Nutr. 2003, 133 (Suppl 3), 956S-964S.
13. Mathey, J., Lamothe, V., Coxam, V., Potier, M. et al., Concentrations of isoflavones in plasma and urine of post-menopausal women chronically ingesting high quantities of soy isoflavones, J. Pharm. Biomed. Anal. 2006, 41, 957-965.
14. Mueller, S. O., Simon, S., Chae, K., Metzler, M., Korach, K. S., Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells, Toxicol. Sci. 2004, 80, 14-25.
15. Harris, D. M., Besselink, E., Henning, S. M., Go, V. L., Heber, D., Phytoestrogens induce differential estrogen receptor alpha- or Beta-mediated responses in transfected breast cancer cells, Exp. Biol. Med. (Maywood, NJ, US) 2005, 230, 558-568.
16. Manas, E. S., Xu, Z. B., Unwalla, R. J., Somers, W. S., Understanding the selectivity of genistein for human estrogen receptor-beta using X-ray crystallography and computational methods, Structure 2004, 12, 2197-2207.
17. Fujita, T., Kobayashi, Y., Wada, O., Tateishi, Y. et al., Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells, J. Biol. Chem. 2003, 278, 26704-26714.
18. Yoon, K., Pallaroni, L., Stoner, M., Gaido, K., Safe, S., Differential activation of wild-type and variant forms of estrogen receptor alpha by synthetic and natural estrogenic compounds using a promoter containing three estrogen-responsive elements, J. Steroid Biochem. Mol. Biol. 2001, 78, 25-32.
19. Wu, F., Safe, S., Differential activation of wild-type estrogen receptor alpha and C-terminal deletion mutants by estrogens, antiestrogens and xenoestrogens in breast cancer cells, J. Steroid Biochem. Mol. Biol. 2007, 103, 1-9.
20. Reid, G., Hubner, M. R., Metivier, R., Brand, H. et al., Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling, Mol. Cell 2003, 11, 695-707.
21. Maggiolini, M., Bonofiglio, D., Marsico, S., Panno, M. L. et al., Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells, Mol. Pharmacol. 2001, 60, 595-602.
22. Seo, H. S., DeNardo, D. G., Jacquot, Y., Laios, I. et al., Stimulatory effect of genistein and apigenin on the growth of breast cancer cells correlates with their ability to activate ER alpha, Breast Cancer Res. Treat. 2006, 99, 121-134.
23. Maggiolini, M., Vivacqua, A., Fasanella, G., Recchia, A. G. et al., The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells, J. Biol. Chem. 2004, 279, 27008-27016.
24. Matsumura, A., Ghosh, A., Pope, G. S., Darbre, P. D., Comparative study of oestrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells, J. Steroid Biochem. Mol. Biol. 2005, 94, 431-443.
25. Schmidt, S., Michna, H., Diel, P., Combinatory effects of phytoestrogens and 17beta-estradiol on proliferation and apoptosis in MCF-7 breast cancer cells, J. Steroid Biochem. Mol. Biol. 2005, 94, 445-449.
26. Vergne, S., Bennetau-Pelissero, C., Lamothe, V., Chantre, P. et al., Higher bioavailability of isoflavones after a single ingestion of a soya-based supplement than a soya-based food in young healthy males, Br. J. Nutr. 2008, 99, 333-344.