Adrenaline in the treatment of anaphylaxis: What is the evidence?

British Medical Journal

Volumn 327, Issue 7427, 2003, Pages 1332-1335

  McLean Tooke, Andrew P C ^a   Bethune, Claire A ^a   Fay, Ann C ^a   Spickett, Gavin P ^a  

^a ROYAL VICTORIA INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; COCAINE; MONOAMINE OXIDASE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT;

ACIDOSIS; ANAPHYLAXIS; BRADYCARDIA; BRONCHOSPASM; COLLOID; CORONARY ARTERY CONSTRICTION; CRYSTALLOID; DRUG BLOOD LEVEL; DRUG CHOICE; DRUG CONTRAINDICATION; DRUG EFFICACY; DRUG INDICATION; DRUG MECHANISM; DRUG OVERDOSE; DRUG SAFETY; EVIDENCE BASED MEDICINE; HEART ARRHYTHMIA; HIGH RISK PATIENT; HUMAN; HYPERTENSION; HYPOXIA; MORTALITY; PATIENT SELECTION; PRIORITY JOURNAL; RESUSCITATION; REVIEW; SELF INJECTION; SIDE EFFECT; TREATMENT OUTCOME;

EID: 0345527963     PISSN: 09598146     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmj.327.7427.1332     Document Type: Review

References (25)

1. Montanaro A, Bardana EJ Jr. The mechanisms, causes and treatment of anaphylaxis. J Invest Clin Immunol 2002;2:2-11.
2. Fischer M. Fortnightly review: treatment of acute anaphylaxis. BMJ 1995;311:731-3.
3. Yocum MW, Butterfield JH, Klein JS, Volcheck GW, Schroeder DS, Silverstein MD. Epidemiology of anaphylaxis in Olmsted County: a population based study. J Allergy Clin Immunol 1999;104:452-6.
4. Stewart AJ, Ewan PJ. The incidence, aetiology and management of anaphylaxis presenting to an accident and emergency department. Q J Med 1996;89:859-64.
5. Klein JS, Yocum MW. Underreporting of anaphylaxis in a community emergency room. J Allergy Clin Immunol 1995;95:637-8.
6. Neugut AI, Ghatak AT, Miller RL. Anaphylaxis in the United States - an investigation into its epidemiology. Arch Intern Med 2001;161:15-21.
7. Johnston SL, Unsworth J, Gompels M. Adrenaline given outside the context of life threatening allergic reactions. BMJ 2003;326:589-90.
8. Pumphrey RSH. Lessons for the management of anaphylaxis from a study of fatal reactions. Clin Exp Allergy 2000;30:1144-50.
9. Brown AFT. Therapeutic controversies in the management of acute anaphylaxis. J Accident Emerg Med 1998;15:89-95.
10. Project Team of the Resuscitation Council (UK). The emergency medical treatment of anaphylactic reactions for first medical responders and for community nurses. Revised Jan 2002. www.resus.org.uk/pages/reaction.htm (accessed Apr 2003).
11. American Association of Allergy, Asthma, and Immunology. Media resources: position statement 26. The use of epinephrine in the treatment of anaphylaxis. www.aaaai.org/media/resources/advocacy_statements/ps26.stm (accessed Apr 2003).
12. Simons F. Epinephrine absorption in children with a history of anaphylaxis. J Clin Immunol 1998;101:33-7.
13. Simons FE, Gu X, Simons KJ. Epinephrine absorption in adults: intramuscular versus subcutaneous injection. J Allergy Clin Immunol 2001;108:871-3.
14. Lang DM. Anaphylactoid and anaphylactic reactions. Hazards of beta-blockers. Drug Safety 1995;12(5):299-304.
15. Ellis MD, Day JH. The role of epinephrine in the treatment of anaphylaxis. Curr Allergy Asthma Rep 2003;3:11-4.
16. Moneret Vautrin DA, Kanny G, Faller JP, Levan D, Kohler C. Severe anaphylactic shock with cardiac arrest caused by coffee and gum Arabic potentiated by beta-blocking eyedrops. Rev Med Interne 1993;14(2): 107-11.
17. Sampson HA, Mendelson L, Rosen JP. Fatal and near-fatal anaphylactic reactions to food in children and adolescents. N Engl J Med 1992;327:380-4.
18. Soreide E, Buxrud T, Harboe S. Severe anaphylactic reactions outside hospital: aeitiology, symptoms and treatment. Acta Anaesthesiol Scand 1988;32:339-42.
19. Macdougall CF, Cant AJ, Colver AF. How dangerous is allergy in childhood? The incidence of severe and fatal allergic reactions across the UK and Ireland. Arch Dis Child 2002;86:236-9.
20. Zimmerman B, Urch B, Mercardo B. Food allergy: frequency of adrenaline administration. Can J Allergy Clin Immunol 2001;6:159-61.
21. Injectable adrenaline for children. Drug Ther Bull 2003;41(3):21-4.
22. Unsworth DJ. Adrenaline syringes are vastly over prescribed. Arch Dis Child 2001;84:410-1.
23. Goldberg A, Confino-Cohen R. Insect sting-inflicted systemic reactions: attitudes of patients with insect venom allergy regarding after-sting behaviour and proper administration of epinephrine. J Allergy Clin Immunol 2000;106:1184-9.
24. Sicherer S. Self-injectable epinephrine: no size fits all! Ann Allergy, Asthma Immunol 20001;86:597-8.
25. Gold MS, Sainsbury R. First aid anaphylaxis management in children prescribed an epinephrine autoinjector device. J Allergy Clin Immunol 2000.106;171-6.