Cytolytic activity of NK cell clones against acute childhood precursor-B-cell leukaemia is influenced by HLA class I expression on blasts and the differential KIR phenotype of NK clones

Bone Marrow Transplantation

Volumn 43, Issue 11, 2009, Pages 875-881

  Feuchtinger, T ^a   Pfeiffer, M ^a   Pfaffle, A ^a   Teltschik, H M ^a   Wernet, D ^b   Schumm, M ^a   Lotfi, R ^b   Handgretinger, R ^a   Lang, P ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD158B ANTIGEN; HLA ANTIGEN CLASS 1; HLA E ANTIGEN; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL1; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 3DL1; LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ALLOIMMUNITY; ANTIGEN EXPRESSION; ARTICLE; BLAST CELL; CELL SURFACE; CHILDHOOD LEUKEMIA; CONTROLLED STUDY; HUMAN; HUMAN CELL; LYMPHOCYTE CLONE; NATURAL KILLER CELL; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL DESTRUCTION;

HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; KILLER CELLS, NATURAL; PHENOTYPE; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RECEPTORS, KIR;

EID: 67549140334     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2008.398     Document Type: Article

References (31)

1. Green A, Clarke E, Hunt L, Canterbury A, Lankester A, Hale G et al Children with acute lymphoblastic leukemia who receive T-cell-depleted HLA mismatched marrow allografts from unrelated donors have an increased incidence of primary graft failure but a similar overall transplant outcome. Blood 1999; 94: 2236-2246.
2. Godder KT, Hazlett LJ, Abhyankar SH, Chiang KY, Christiansen NP, Bridges KD et al. Partially mismatched related-donor bone marrow transplantation for pediatric patients with acute leukemia: Younger donors and absence of peripheral blasts improve outcome. J Clin Oncol 2000; 18: 1856-1866.
3. Lang P, Handgretinger R, Niethammer D, Schlegel PG, Schumm M, Greil J et al. Transplantation of highly purified CD34+ progenitor cells from unrelated donors in pediatric leukemia. Blood 2003; 101: 1630-1636.
4. Bunin N, Carston M, Wall D, Adams R, Casper J, Kamani N et al. Unrelated marrow transplantation for children with acute lymphoblastic leukemia in second remission. Blood 2002; 99: 3151-3157.
5. Rocha V, Cornish J, Sievers EL, Filipovich A, Locatelli F, Peters C et al. Comparison of outcomes of unrelated bone marrow and umbilical cord blood transplants in children with acute leukemia. Blood 2001; 97: 2962-2971.
6. Oakhill A, Pamphilon DH, PotterMN, Steward CG, Goodman S, Green A et al. Unrelated donor bone marrow transplantation for children with relapsed acute lymphoblastic leukaemia in second complete remission. Br J Haematol 1996; 94: 574-578.
7. Moga E, Alvarez E, Canto E, Vidal S, Rodriguez-Sanchez JL, Sierra J et al. NK cells stimulated with IL-15 or CpG ODN enhance rituximab-dependent cellular cytotoxicity against B-cell lymphoma. Exp Hematol 2008; 36: 69-77.
8. Passweg JR, Tichelli A, Meyer-Monard S, Heim D, Stern M, Kuhne T et al. Purified donor NK-lymphocyte infusion to consolidate engraftment after haploidentical stem cell transplantation. Leukemia 2004; 18: 1835-1838.
9. Ruggeri L, Capanni M, Casucci M, Volpi I, Tosti A, Perruccio K et al Role of natural killer cell alloreactivity in HLAmismatched hematopoietic stem cell transplantation. Blood 1999; 94: 333-339.
10. Ruggeri L, Capanni M, Urbani E, Perruccio K, Shlomchik WD, Tosti A et al. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 2002; 295: 2097-2100.
11. Pfeiffer M, Schumm M, Feuchtinger T, Dietz K, Handgretinger R, Lang P. Intensity of HLA class I expression and KIR-mismatch determine NK-cell mediated lysis of leukaemic blasts from children with acute lymphatic leukaemia. Br J Haematol 2007; 138: 97-100.
12. Valiante NM, Uhrberg M, Shilling HG, Lienert-Weidenbach K, Arnett KL, D'Andrea A et al. Functionally and structurally distinct NK cell receptor repertoires in the peripheral blood of two human donors. Immunity 1997; 7: 739-751.
13. Ciccone E, Pende D, Viale O, Di Donato C, Tripodi G, Orengo AM et al Evidence of a natural killer (NK) cell repertoire for (allo) antigen recognition: Definition of five distinct NK-determined allospecificities in humans. J Exp Med 1992; 175: 709-718.
14. Parham P. MHC class I molecules and KIRs in human history, health and survival. Nat Rev Immunol 2005; 5: 201-214.
15. Colonna M, Samaridis J. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 1995; 268: 405-408.
16. Karre K. Immunology. A perfect mismatch. Science 2002; 295: 2029-2031.
17. LiaoNS, Bix M, Zijlstra M, Jaenisch R, Raulet D. MHC class I deficiency: susceptibility tonatural killer (NK) cells and impaired NK activity. Science 1991; 253: 199-202.
18. Ljunggren HG, Karre K. In search of the 'missing self': MHC molecules and NK cell recognition. Immunol Today 1990; 11: 237-244.
19. Sawicki MW, Dimasi N, Natarajan K, Wang J, Margulies DH, Mariuzza RA. Structural basis of MHC class I recognition by natural killer cell receptors. Immunol Rev 2001; 181: 52-65.
20. Lang P, Barbin K, Feuchtinger T, Greil J, Peipp M, Zunino SJ et al Chimeric CD19 antibody mediates cytotoxic activity against leukemic blasts with effector cells from pediatric patients whoreceived T-cell-depleted allografts. Blood 2004; 103: 3982-3985.
21. Leung W, Iyengar R, Turner V, Lang P, Bader P, Conn P et al. Determinants of antileukemia effects of allogeneic NK cells. J Immunol 2004; 172: 644-650.
22. Beelen DW, Ottinger HD, Ferencik S, Elmaagacli AH, Peceny R, Trenschel R et al. Genotypic inhibitory killer immunoglobulin- like receptor ligand incompatibility enhances the longterm antileukemic effect of unmodified allogeneic hematopoietic stem cell transplantation in patients with myeloid leukemias. Blood 2005; 105: 2594-2600.
23. Gagne K, Brizard G, GueglioB, Milpied N, Herry P, Bonneville F et al Relevance of KIR gene polymorphisms in bone marrow transplantation outcome. Hum Immunol 2002; 63: 271-280.
24. Giebel S, Locatelli F, Lamparelli T, Velardi A, Davies S, Frumento G et al. Survival advantage with KIR ligand incompatibility in hematopoietic stem cell transplantation from unrelated donors. Blood 2003; 102: 814-819.
25. Verheyden S, Bernier M, Demanet C. Identification of natural killer cell receptor phenotypes associated with leukemia. Leukemia 2004; 18 2002-2007.
26. Verheyden S, Demanet C. Susceptibility to myeloid and lymphoid leukemia is mediated by distinct inhibitory KIRHLA ligand interactions. Leukemia 2006; 20: 1437-1438.
27. Feuchtinger T, Schumm M, Weinstock C, Handgretinger R, Greil J, Niethammer D et al. Regeneration of KIR receptors on NK-cells in children after allogeneic stem cell transplantation: HLA independent predominance of CD158b. Bone Marrow Transplantation 2003; 31 S121.
28. Kim S, Poursine-Laurent J, Truscott SM, Lybarger L, Song YJ, Yang L et al. Licensing of natural killer cells by host major histocompatibility complex class I molecules. Nature 2005; 436 709-713.
29. Fernandez NC, Treiner E, Vance RE, Jamieson AM, Lemieux S, Raulet DH. A subset of natural killer cells achieves selftolerance without expressing inhibitory receptors specific for self-MHC molecules. Blood 2005; 105: 4416-4423.
30. Cooley S, Xiao F, Pitt M, Gleason M, McCullar V, Bergemann TL et al A subpopulation of human peripheral blood NK cells that lacks inhibitory receptors for self-MHC is developmentally immature. Blood 2007; 110: 578-586.
31. Yu J, Heller G, Chewning J, Kim S, Yokoyama WM, Hsu KC. Hierarchy of the human natural killer cell response is determined by class and quantity of inhibitory receptors for self-HLA-B and HLA-C ligands. J Immunol 2007; 179: 5977-5989.