Children with acute lymphoblastic leukemia who receive T-cell-depleted HLA mismatched marrow allografts from unrelated donors have an increased incidence of primary graft failure but a similar overall transplant outcome

Blood

Volumn 94, Issue 7, 1999, Pages 2236-2246

  Green, Ann ^b   Clarke, Emer ^b   Hunt, Linda ^b   Canterbury, Andrew ^b   Lankester, Alan ^b   Hale, Geoff ^b   Waldmann, Herman ^b   Goodman, Sally ^b   Cornish, Jacqueline M ^b   Marks, David I ^b   Steward, Colin G ^b   Oakhill, Anthony ^b   Pamphilon, Derwood H ^a  

^a BRISTOL ROYAL HOSPITAL FOR CHILDREN   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; CYCLOSPORIN A; HLA A ANTIGEN; HLA B ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN; METHOTREXATE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ARTICLE; BONE MARROW TRANSPLANTATION; CANCER RECURRENCE; CANCER SURVIVAL; CHILD; CONTROLLED STUDY; FEMALE; GRAFT FAILURE; HLA MATCHING; HUMAN; INCIDENCE; LEUKEMIA REMISSION; LYMPHOCYTE DEPLETION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK ASSESSMENT; TREATMENT OUTCOME;

EID: 0033214208     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.7.2236.419k04_2236_2246     Document Type: Article

References (43)

1. Chessells JM, Bailey C, Richards SM: Intensification of treatment and survival in all children with lymphoblastic leukemia: Results of UK Medical Research Council trial UKALL X. Medical Research Council Working Party on Childhood Leukemia. Lancet 345:143, 1995
2. Rivera GK: Advances in therapy for childhood non-B-lymphoblastic leukemia. (Review) Baillière's Clin Haematol 7:273, 1994
3. Behrendt H, van Leeuwen EF, Schuwirth C, Verkes RJ, van Hermans J, der Does-van den Berg A, van Wering ER: Bone marrow relapse occurring as first relapse in children with acute lymphoblastic leukemia. Med Paediatr Oncol 19:190, 1990
4. Henze G, Fengler R, Hartmann R, Kornhuber B, Janka-Schaub G, Niethammer D, Riehm H: Six-year experience with a comprehensive approach to the treatment of recurrent childhood acute lymphoblastic leukemia (ALL-REZ BFM 85). A relapse study of the BFM Group. Blood 78:1166, 1991
5. Barrett AJ, Horowitz MM, Pollock BH, Zhang M-J, Bortin MM, Buchanan GR, Camitta BM, Ochs J, Graham-Pole J, Rowlings PA, Rimm AA, Klein JP, Shuster JJ, Sobocinski KA, Gale RP: Bone marrow transplants from HLA-identical siblings as compared with chemotherapy for children with acute lymphoblastic leukemia in a second remission. N Engl J Med 331:1253, 1994
6. Dopfer R, Henze G, Bender-Götze C, Ebell W, Ehninger G, Friedrich W, Gadner H, Klingebiel T, Peters C, Riehm H, Suttorp M, Schmid H, Schmitz N, Siegert W, Stollman-Gibbels B, Hartmann R, Niethammer D: Allogeneic bone marrow transplantation for childhood acute lymphoblastic leukemia in second remission after intensive primary and relapse therapy according to the BFM- and CoALL-protocols: Results of the German Cooperative study. Blood 10:2780, 1991
7. Torres A, Martínez F, Gómez P, Fornés G, Rojas R, Herrera C, Gómez JL, Manzanares R, García JM, Andres P, Velasco F, Avarez MA, Rodríguez JM, Parody R, Plaza E, León A, Romero R, Jean Paul E, Prados D, Aljama R, Fernández A, González V, Herrador M, Vidarte M, Garcia JL, Errazquin L: Allogeneic bone marrow transplantation versus chemotherapy in the treatment of childhood acute lymphoblastic leukemia in second complete remission. Bone Marrow Transplant 4:609, 1989
8. Franklin IM: A consensus statement on unrelated donor bone marrow transplantation from the Consensus Panel chaired by EC Gordon-Smith. Bone Marrow Transplant 19:959, 1997
9. Sierra J, Radich J, Hansen JA, Martin PJ, Petersdorf EW, Bjerke J, Bryant E, Nash RA, Sanders JE, Storb R, Sullivan KM, Appelbaum FR, Anasetti C: Marrow transplants from unrelated donors for treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood 90:1410, 1997
10. Marks DI, Bird JM, Cornish JM, Goulden NJ, Jones CG, Knechtli CJC, Pamphilon DH, Steward CG, Oakhill A: Unrelated donor bone marrow transplantation for children and adolescents with Philadelphia-positive acute lymphoblastic leukemia. J Clin Oncol 16:931, 1998
11. Kernan NA, Bartsch G, Ash RC, Beatty PG, Champlin R, Filipovich A, Gajewski J, Hansen JA, Henslee-Downey J, McCullough J, McGlave P, Perkins HA, Phillips GL, Sanders J, Stroncek D, Thomas ED, Blume KG: Analysis of 462 transplantations from unrelated donors facilitated by the National Marrow Donor Program. N Engl J Med 328:593, 1993
12. Ash RC, Casper J, Chitambar CR, Hansen R, Bunin N, Truitt RL, Lawton C, Murray K, Hunter J, Baxter-Lowe LA, Gottschall JL, Oldham K, Andersen T, Camitta B, Menitove J: Successful allogeneic transplantation of T-cell-depleted bone marrow from closely HLA-matched unrelated donors. N Engl J Med 322:485, 1990
13. Davies SM, Ramsay NKC, Haake RJ, Kersey JH, Weisdorf DJ, McGlave PB, Blazar BR: Comparison of engraftment in recipients of matched sibling or unrelated donor marrow allografts. Bone Marrow Transplant 13:51, 1994
14. Balduzzi A, Gooley T, Anasetti C, Sanders JE, Martin PJ, Petersdorf EW, Appelbaum FR, Buckner CD, Matthews D, Storb R, Sullivan KM, Hansen JA: Unrelated donor marrow transplantation in children. Blood 86:3247, 1995
15. Davies SM, Wagner JE, Xiao-Ou S, Blazar BR, Katsanis E, Orchard PJ, Kersey JH, Dusenberg KF, Weisdorf DJ, McGlave AB, Ramsey NKC: Unrelated donor bone marrow transplantation for children with acute leukemia. J Clin Oncol 15:557, 1997
16. Casper J, Camitta B, Truitt R, Baxter-Lowe LA, Bunin N, Lawton C, Murray K, Hunter J, Pietryga D, Garbrecht F, Taylor CK, Drobyski W, Horowitz M, Flomenberg N, Ash R: Unrelated bone marrow donor transplants for children with leukemia or myelodysplasia. Blood 85:2354, 1995
17. Beatty PG, Anasetti C, Hansen JA, Longton GM, Sanders JE, Martin PJ, Mickelson EM, Choo SY, Petersdorf EW, Pepe MS, Appelbaum FR, Bearman SI, Buckner CD, Clift RA, Petersen FB, Singer J, Stewart PS, Storb RF, Sullivan KM, Tesler MC, Witherspoon RP, Thomas ED: Marrow transplantation from unrelated donors for treatment of hematologic malignancies: Effect of mismatching for one HLA locus. Blood 81:249, 1993
18. Spencer A, Szydlo RM, Brookes PM, Kaminski E, Rule S, van Rhee F, Ward KN, Hale G, Waldmann H, Hows JM, Batchelor R, Goldman JM: Bone marrow transplantation for chronic myeloid leukemia with volunteer unrelated donors using ex vivo or in vivo T-cell depletion: Major prognostic impact of HLA class I identity between donor and recipient. Blood 86:3590, 1995
19. Davies SM, Shu XO, Blazar BR, Filipovich AH, Kersey JH, Krivit W, McCullough J, Miller WJ, Ramsay NKC, Segall M, Wagner JE, Weisdorf DJ, McGlave PB: Unrelated donor bone marrow transplantation: Influence of HLA A and B incompatibility on outcome. Blood 86:1636, 1995
20. Petersdorf EW, Longton GM, Anasetti C, Mickelson EM, McKinney SK, Smith AG, Martin PJ, Hansen JA: Association of HLA-C disparity with graft failure after marrow transplantation from unrelated donors. Blood 89:1818, 1997
21. Anasetti C, Amos D, Beatty PG, Appelbaum FR, Bensinger W, Buckner CD, Clift RA, Doney K, Martin PJ, Mickelson E, Nisperos B, O'Quigley J, Ramberg R, Sanders JE, Stewart P, Storb R, Sullivan K, Witherspoon R, Thomas ED, Hansen JA: Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphoma. N Engl J Med 320:197, 1989
22. Nagler A, Brautbar C, Slavin S, Bishara A: Bone marrow transplantation using unrelated and family related donors: The impact of HLA-C disparity. Bone Marrow Transplant 18:891, 1996
23. Sasazuki T, Juji T, Morishma Y, Kinukawa N, Kashiwabara H, Inoko H, Yoshida T, Kimura A, Akaza T, Kamikawaji N, Kodera Y, Takaku F: Effect of matching of class I HLA alleles on clinical outcome after transplantation of hemopoietic stem cells from an unrelated donor. N Engl J Med 339:1177, 1998
24. Devergie A, Apperley JF, Labopin M, Madrigal A, Jacobsen N, Carreras E, Prentice HG, Jouet JP, Kolb HJ, Herstenstein B, Bacigalupo A, Evensen SA, Ljungman P, de Witte T, Reiffers J, Nagler A, Clarke RE, Goldman JM, Gratwohl A: European results of matched unrelated donor bone marrow transplantation for chronic myeloid leukemia. Impact of HLA class II matching. Bone Marrow Transplant 20:11, 1997
25. Petersdorf EW, Longton GM, Anasetti C, Martin PJ, Mickelson EM, Smith AG, Hansen JA: The significance of HLA-DRBI matching on clinical outcome after HLA-A, B, DR identical unrelated donor marrow transplantation. Blood 86:1606, 1995
26. Speiser DE, Tiercy J-M, Rufer N, Grundschober C, Gratwohl A, Chapuis B, Helg C, Löliger CC, Siren M-K, Roosnek E, Jeannet M: High resolution HLA matching associated with decreased mortality after unrelated bone marrow transplantation. Blood 87:4455, 1996
27. Hansen JA, Gooley TA, Martin PJ, Appelbaum F, Chauncey TR, Clift RA, Petersdorf EW, Radich J, Sanders JE, Storb RF, Sullivan KM, Anasetti C: Bone marrow transplants from unrelated donors for patients with chronic myeloid leukemia. N Engl J Med 338:962, 1998
28. Sierra J, Storer B, Hansen JA, Bjerke JW, Martin PJ, Petersdorf EW, Appelbaum FR, Bryant E, Chauncey TR, Sale G, Sanders JE, Storb R, Sullivan KM, Anasetti C: Transplantation of marrow cells from unrelated donors for treatment of high-risk acute leukemia: The effect of leukemic burden, donor HLA-matching, and marrow cell dose. Blood 89:4226, 1997
29. Oakhill A, Pamphilon DH, Potter MN, Steward CG, Goodman S, Green A, Goulden P, Goulden NJ, Hale G, Waldmann H, Cornish JMM: Unrelated donor bone marrow transplantation for children with relapsed acute lymphoblastic leukemia in second complete remission. Br J Haematol 94:574, 1996
30. Working Party on Leukemia in Childhood: Improvement in treatment for children with acute lymphoblastic leukemia; the Medical Research Council UKALL Trials 1972-84. Lancet 1:408, 1986
31. Baxter-Lowe LA: Molecular techniques for typing unrelated marrow donors: Potential impact of molecular typing disparity on donor selection. Bone Marrow Transplant 14:S42, 1994
32. Knipper AJ, Hinney A, Schuch B, Enczmann J, Uhrberg M, Wernet P: Selection of unrelated bone marrow donors by PCR-SSP typing and subsequent non-radioactive sequence-based typing for HLA DRB1/3/4/5. DQB1, and DPB1 alleles. Tissue Antigens 44:275, 1994
33. Hale G, Waldmann H for CAMPATH Users: Recent results using CAMPATH-1 antibodies to control GVHD and graft rejection. Bone Marrow Transplant 17:305, 1996
34. Potter MN, Pamphilon DH, Cornish JM, Oakhill A: Graft versus host disease in children receiving HLA-identical allogeneic bone marrow transplants with a low adjusted T lymphocyte dose. Bone Marrow Transplant 8:357, 1991
35. Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA, Lerner KG, Thomas ED: Clinical manifestations of graft-versus-host disease in human recipients of marrow from HLA-matched sibling donors. Transplantation 18:295, 1974
36. Sullivan KM, Shulman HM, Storb R, Weiden PL, Witherspoon RP, McDonald GB, Shubert MM, Atkinson K, Thomas ED: Chronic graft-versus-host disease in 52 patients: Adverse natural course and successful treatment with combination immunosuppression. Blood 57:267, 1981
37. Reed SJ, Jeffery KJM, Banghem CRH: Aseptic meningitis and encephalitis: The role of PCR in the diagnostic laboratory. J Clin Microbiol 35:691, 1997
38. Feinstein AR: Multivariable Analysis - An Introduction. New Haven, CT, Yale University, 1996, p 226, 354
39. Bodmer JG, Marsh SGE, Albert ED, Bontrop RE, Charron D, Dupont B, Erhlich HA, Mach B, Mayr WR, Parham P, Sasazuki T, Schreuder GM, Strominger JL, Svejgaard A, Terasaki PI: Nomenclature for factors of the HLA system. Tissue Antigens 46:73; 1995
40. Molloy K, Goulden N, Lawler M, Cornish J, Oakhill A, Pamphilon D, Potter M, Steward C, Langlands K, Humphries P, McCann SR: Patterns of hematopoietic chimerism following bone marrow transplantation for childhood acute lymphoblastic leukemia from volunteer unrelated donors. Blood 87:3027, 1996
41. Hongend S, Krance RA, Bowman LC, Srivastava DK, Cunningham JM, Horowitz EM, Brenner MK, Heslop HE: Outcomes of transplantation with matched sibling and unrelated-donor bone marrow in children with leukemia. Lancet 250:767, 1997
42. Hale G, Zhang M-J, Bunjes D, Prentice HG, Spence D, Horowitz MM, Barrett AJ, Waldmann H: Improving the outcome of bone marrow transplantation by using CD52 monoclonal antibodies to prevent graft-versus-host disease and graft rejection. Blood 92:4581, 1998
43. Knechtli CJC, Goulden NJ, Hancock JP, Grandage VLG, Harris EL, Garland RJ, Jones CG, Rowbottom AW, Hunt LP, Green AF, Clarke E, Lankester AW, Cornish JM, Pamphilon DH, Steward CG, Oakhill A: Minimal residual disease status before allogeneic bone marrow transplantation is an important determinant of successful outcome for children and adolescents with acute lymphoblastic leukemia. Blood 92:4072, 1998