Smoking confers a MTHFR 677C>T genotype-dependent risk for systemic atherosclerosis: Results from a large number of elderly autopsy cases that died in a community-based general geriatric hospital

Journal of Atherosclerosis and Thrombosis

Volumn 16, Issue 2, 2009, Pages 91-104

  Sawabe, Motoji ^a   Arai, Tomio ^a   Araki, Atsushi ^a   Hosoi, Takayuki ^b   Kuchiba, Aya ^c   Tanaka, Noriko ^d   Naito, Takahiro ^e   Oda, Kanae ^e   Ikeda, Shinobu ^e   Muramatsu, Masaaki ^e  

^a Tokyo Metropolitan Institute of Gerontology   (Japan)

^b NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Atherosclerosis; Genetic polymorphism; MTHFR; Smoking

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CYTOSINE; THYMINE;

AGED; ARTICLE; ATHEROSCLEROSIS; AUTOPSY; BRAIN ATHEROSCLEROSIS; CARDIOVASCULAR RISK; COMMON CAROTID ARTERY; CONTROLLED STUDY; CORONARY ARTERY ATHEROSCLEROSIS; FEMALE; FEMORAL ARTERY; GENETIC RISK; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN TISSUE; ILIAC ARTERY; MAJOR CLINICAL STUDY; MALE; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING;

EID: 67549123813     PISSN: 13403478     EISSN: 18803873     Source Type: Journal    
DOI: 10.5551/jat.E612     Document Type: Article

References (20)

1. Batra V, Patkar AA, Berrettini WH, Weinstein SP, Leone FT: The genetic determinants of smoking. Chest, 2003; 123:1730-1739
2. Salama SA, Au WW, Hunter GC, Sheahan RG, Badary OA, Abdel-Naim AB, Hamada FM: Polymorphic metabolizing genes and susceptibility to atherosclerosis among cigarette smokers. Environ Mol Mutagen, 2002; 40:153-160
3. Wang XL, Wang J: Smoking-gene interaction and disease development: relevance to pancreatic cancer and atherosclerosis. World J Surg, 2005; 29:344-353
4. Sawabe M, Arai T, Kasahara I, Esaki Y, Nakahara K, Hosoi T, Orimo H, Takubo K, Murayama S, Tanaka N: Development of a geriatric autopsy database and Internetbased database of Japanese single nucleotide polymorphisms for geriatric research (JG-SNP). Mech Ageing Dev, 2004; 125:547-552
5. Sawabe M, Arai T, Kasahara I, Hamamatsu A, Esaki Y, Nakahara K, Harada K, Chida K, Yamanouchi H, Ozawa T, Takubo K, Murayama S, Tanaka N: Sustained progression and loss of the gender-related difference in atherosclerosis in the very old: a pathological study of 1074 consecutive autopsy cases. Atherosclerosis, 2006; 186:374-379
6. Chida K, Ohkawa S, Watanabe C, Shimada H, Ohtsubo K, Sugiura M: A morphological study of the normally aging heart. Cardiovasc Pathol, 1994; 3:1-7
7. Koyama S, Saito Y, Yamanouchi H, Nagura H, Chida K, Arai T, Sawabe M, Iwamoto T, Takasaki M, Murayama S: Marked decrease of intracranial atherosclerosis in contrast with unchanged coronary artery stenosis in Japan. Nippon Ronen Igakkai Zasshi, 2003; 40:267-273
8. Oda K, Tanaka N, Arai T, Araki J, Song Y, Zhang L, Kuchiba A, Hosoi T, Shirasawa T, Muramatsu M, Sawabe M: Polymorphisms in pro- and anti-inflammatory cytokine genes and susceptibility to atherosclerosis: a pathological study of 1503 consecutive autopsy cases. Hum Mol Genet, 2007; 16:592-599
9. Nygård O, Vollset SE, Refsum H, Stensvold I, Tverdal A, Nordrehaug JE, Ueland PM, Kvåle G: Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study. JAMA, 1995; 274:1526-1533
10. Refsum H, Nurk E, Smith AD, Ueland PM, Gjesdal CG, Bjelland I, Tverdal A, Tell GS, Nygård O, Vollset SE: The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease. J Nutr, 2006; 136:1731S-1740S
11. van den Berg H, van der Gaag M, Hendriks H: Influence of lifestyle on vitamin bioavailability. Int J Vitam Nutr Res, 2001; 72:53-59
12. Maruyama C, Araki R, Takeuchi M, Kuniyoshi E, Iwasawa A, Maruyama T, Nakano S, Motohashi Y, Nakanishi M, Kyotani S, Tsushima M: Relationships of nutrient intake and lifestyle-related factors to serum folate and plasma homocysteine concentrations in 30-69 year-old Japanese. J Nutr Sci Vitaminol (Tokyo), 2004; 50:1-8
13. Klerk M, Verhoef P, Clarke R, Blom HJ, Kok FJ, Schouten EG; MTHFR Studies Collaboration Group. MTHFR 677C T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA, 2002; 288:2023-2031
14. Brown KS, Kluijtmans LA, Young IS, Murray L, McMaster D, Woodside JV, Yarnell JW, Boreham CA, McNulty H, Strain JJ, McPartlin J, Scott JM, Mitchell LE, Whitehead AS: The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine. Atherosclerosis, 2004; 174:315-322
15. Inamoto N, Katsuya T, Kokubo Y, Mannami T, Asai T, Baba S, Ogata J, Tomoike H, Ogihara T: Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population. Stroke, 2003; 34:1628-1633
16. Hara K, Boutin P, Mori Y, Tobe K, Dina C, Yasuda K, Yamauchi T, Otabe S, Okada T, Eto K, Kadowaki H, Hagura R, Akanuma Y, Yazaki Y, Nagai R, Taniyama M, Matsubara K, Yoda M, Nakano Y, Tomita M, Kimura S, Ito C, Froguel P, Kadowaki T: Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes, 2002; 51:536-540
17. Imatoh T, Miyazaki M, Kadowaki K, Babazono A, Sato M, Une H: Interaction of low serum adiponectin levels and smoking on coronary stenosis in Japanese men. Int J Cardiol, 2006; 110:251-255
18. Qi L, Doria A, Manson JE, Meigs JB, Hunter D, Mantzoros CS, Hu FB: Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes. Diabetes, 2006; 55:1512-1516
19. Sethi AA, Nordestgaard BG, Tybjaerg-Hansen A: Angiotensinogen gene polymorphism, plasma angiotensinogen, and risk of hypertension and ischemic heart disease: a meta-analysis. Arterioscler Thromb Vasc Biol, 2003; 23:1269-1275
20. Xu M-Q, Ye Z, Hu FB, He L: Quantitative assessment of the effect of angiotensinogen gene polymorphisms on the risk of coronary heart disease. Circulation, 2007; 116:1356-1366