A Phase 3b, Open-Label, Single-Group Immunogenicity and Safety Study of Topical Recombinant Thrombin in Surgical Hemostasis

Journal of the American College of Surgeons

Volumn 209, Issue 1, 2009, Pages 68-74

  Singla, Neil K ^a   Ballard, Jeffrey L ^b   Moneta, Gregory ^c   Randleman Jr , C Duane ^d   Renkens, Kenneth L ^e   Alexander, W Allan ^f  

^a HUNTINGTON MEMORIAL HOSPITAL   (United States)

^b Orange County Inc   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d Cardiothoracic Surgeons   (United States)

^e INDIANA SPINE GROUP   (United States)

^f ZYMOGENETICS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; RECOTHROM; THROMBIN; THROMBIN ANTIBODY; UNCLASSIFIED DRUG; WARFARIN;

ADULT; AGE DISTRIBUTION; AGED; ANEMIA; ANTIBODY TITER; ARTERIOVENOUS VASCULAR ACCESS PROCEDURE; ARTERY BYPASS; ARTERY RECONSTRUCTION; ARTICLE; CLINICAL TRIAL; COMORBIDITY; CONSTIPATION; DEEP VEIN THROMBOSIS; DRUG EFFICACY; DRUG SAFETY; ERYTHEMA; FEMALE; FEVER; HEART ATRIUM FIBRILLATION; HEART INFARCTION; HEMOSTASIS; HIGH RISK PATIENT; HUMAN; HYPERKALEMIA; HYPOTENSION; IMMUNE RESPONSE; IMMUNOGENICITY; LABORATORY TEST; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MUSCLE SPASM; NAUSEA; PAIN; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; PRURITUS; RESPIRATORY FAILURE; SEROCONVERSION; SPINE SURGERY; SURGICAL TECHNIQUE; VASCULAR SURGERY; WOUND FLUID;

ADMINISTRATION, TOPICAL; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; ANTIBODY FORMATION; BLOOD LOSS, SURGICAL; CATTLE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEMOSTASIS, SURGICAL; HEMOSTATICS; HUMANS; MALE; MIDDLE AGED; RECOMBINANT PROTEINS; SPINAL DISEASES; THROMBIN; TREATMENT OUTCOME; VASCULAR SURGICAL PROCEDURES;

EID: 67549111906     PISSN: 10727515     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jamcollsurg.2009.03.016     Document Type: Article

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