Chiral separation of basic and zwitterionic drugs by highly sulfated cyclodextrins using short-end injection capillary electrophoresis

Iranian Journal of Pharmaceutical Research

Volumn 7, Issue 4, 2008, Pages 275-281

  Zandkarimi, Majid ^a,b   Shafaati, Alireza ^a   Foroutan, Sayyed Mohsen ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ZABOL UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Basic drugs; Capillary electrophoresis; Chiral; Highly sulfated cyclodextrins; Short end injection; Zwitterionic drugs

Indexed keywords

AMPHOLYTE; ATROPINE; BACLOFEN; CHLOROQUINE; CITALOPRAM; CYCLODEXTRIN; METOPROLOL TARTRATE; OFLOXACIN; PROPRANOLOL; SILICON DIOXIDE; TRAMADOL; VERAPAMIL;

ARTICLE; CAPILLARY ELECTROPHORESIS; CHIRALITY; DRUG ANALYSIS; DRUG STRUCTURE; ENANTIOMER; SEPARATION TECHNIQUE; SURFACE CHARGE;

EID: 67549102791     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Gubitz G and Schmid MG. Recent progress in chiral separation principles in capillary electrophoresis. Electrophoresis (2000) 21: 4112-35
2. Fanali S. Controlling enantioselectivity in chiral capillary electrophoresis with inclusion-complexation. J. Chromatogr. A (1997) 792: 227-67
3. Gubitz G and Schmid MG. Chiral separation by chromatographic and electromigration techniques. A review. Biopharm. Drug Dispos. (2001) 22: 291-336
4. Gubitz G and Schmid MG. Chiral separation principles in chromatographic and electromigration techniques. Mol. Biotechnol. (2006) 32: 159-80
5. Roussel C, Del Rio A, Pierrot-Sanders J, Piras P and Vanthuyne N. Chiral liquid chromatography contribution to the determination of the absolute configuration of enantiomers. J. Chromatogr. A (2004) 1037: 311-28
6. Aboul-Enein HY, El-Awady MI, Heard CM and Nicholls PJ. Application of thin-layer chromatography in enantiomeric chiral analysis - an overview. Biomed. Chromatogr. (1999) 13: 531-37
7. Schurig V. Separation of enantiomers by gas chromatography. J. Chromatogr. A (2001) 906: 275-99
8. Abbott E, Veenstra TD and Issaq HJ. Clinical and pharmaceutical applications of packed-column supercritical fluid chromatography. J. Sep. Sci. (2008) 31(8): 1223-30
9. Fanali S. Enantioselective determination by capillary electrophoresis with cyclodextrins as chiral selectors. J. Chromatogr. A (2000) 875: 89-122
10. Sanchez-Hernandez L, Crego AL, Marina ML and Garcia-Ruiz C. Sensitive chiral analysis by CE: an update. Electrophoresis (2008) 29: 237-51
11. Chankvetadze B and Blaschke G. Enantioseparations in capillary electromigration techniques: recent developments and future trends. J. Chromatogr. A (2001) 906: 309-63
12. Kafri R and Lancet D. Probability rule for chiral recognition. Chirality (2004) 16: 369-78
13. Blaschke G and Chankvetadze B. Enantiomer separation of drugs by capillary electromigration techniques. J. Chromatogr. A (2000) 875: 3-25
14. Rizzi A. Fundamental aspects of chiral separations by capillary electrophoresis. Electrophoresis (2001) 22: 3079-106
15. Amini A. Recent developments in chiral capillary electrophoresis and applications of this technique to pharmaceutical and biomedical analysis. Electrophoresis (2001) 22: 3107-30
16. Ha PT, Hoogmartens J and Van Schepdael A. Recent advances in pharmaceutical applications of chiral capillary electrophoresis. J. Pharm. Biomed. Anal. (2006) 41: 1-11
17. Chen FTA and Evangelista RA. Applications of highly sulfated cyclodextrins for enantiomeric separation by capillary electrophoresis. J. Chin. Chem. Soc. (1999) 46: 847-60
18. Chen FTA, Shen G and Evangelista RA. Characterization of highly sulfated cyclodextrins. J. Chromatogr. A (2001) 924: 523-32
19. Bergholdt AB and Lehmann SV. High-speed separation of ormeloxifene enantiomers using sulfated b-cyclodextrin in capillary electrophoresis. Chirality (1998) 10: 699-704
20. Altria KD, Kelly MA and Clark BJ. The use of a short-end injection procedure to achieve improved performance in capillary electrophoresis. Chromatographia (1996) 43: 153-58
21. Fanali S, Aturki Z and Desiderio C. New strategies for chiral analysis of drugs by capillary electrophoresis. Forensic Sci. Int. (1998) 92: 137-55
22. Zandkarimi M, Shafaati A, Foroutan SM and Lucy CA. Separation of Amlodipine Enantiomers by Capillary Electrophoresis Using Highly Sulfated Cyclodextrins. J. Pharm. & Pharm. Sci. (2008) (Submitted)
23. Iwata YT, Garcia A, Kanamori T, Inoue H, Kishi T and Lurie IS. The use of a highly sulfated cyclodextrin for the simultaneous chiral separation of amphetamine-type stimulants by capillary electrophoresis. Electrophoresis (2002) 23: 1328-34
24. Stalcup AM and Gahm KH. Application of sulfated cyclodextrins to chiral separations by capillary zone electrophoresis. Anal. Chem. (1996) 68: 1360-8
25. Gahm KH and Stalcup AM. Sulfated cyclodextrins for the chiral separations of catecholamines and related compounds in the reversed electrophoretic polarity mode. Chirality (1996) 8: 316-24
26. Vela J, Yanes EG and Stalcup AM. Quantitative determination of clenbuterol, salbutamol and tulobuterol enantiomers by capillary electrophoresis. Fresenius J. Anal. Chem. (2001) 369: 212-9
27. Evans CE and Stalcup AM. Comprehensive strategy for chiral separations using sulfated cyclodextrins in capillary electrophoresis. Chirality (2003) 15: 709-23
28. Green JS and Jorgenson JW. Minimizing adsorption of proteins on fused-silica in capillary zone electrophoresis by the addition of alkali-metal salts to the buffers. J. Chromatogr. (1989) 478: 63-70
29. Bushey MM and Jorgenson JW. Capillary electrophoresis of proteins in buffers containing high concentrations of zwitterionic salts. J. Chromatogr. (1989) 480: 301-10
30. Melanson JE, Baryla NE and Lucy CA. Dynamic capillary coatings for electroosmotic flow control in capillary electrophoresis. Trends Anal. Chem. (2001) 20: 365-74
31. Doherty EA, Meagher RJ, Albarghouthi MN and Barron AE. Microchannel wall coatings for protein separations by capillary and chip electrophoresis. Electrophoresis (2003) 24: 34-54
32. Chankvetadze B. Separation selectivity in chiral capillary electrophoresis with charged selectors. J. Chromatogr. A (1997) 792: 269-75