Clevidipine: A novel ultra-short-acting calcium antagonist

Cardiology in Review

Volumn 17, Issue 3, 2009, Pages 147-152

  Prlesi, Lendita ^a   Cheng Lai, Angela ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Calcium antagonists; Clevidipine; Perioperative hypertension; Severe hypertension

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CLEVIDIPINE; CLEVIPREX; ENALAPRILAT; ESMOLOL; FENOLDOPAM; FENOLDOPAM MESILATE; GLYCERYL TRINITRATE; HYDRALAZINE; LABETALOL; NICARDIPINE; NIFEDIPINE; NITROPRUSSIDE SODIUM; PLACEBO; UNCLASSIFIED DRUG; ANTIHYPERTENSIVE AGENT; CALCIUM; PYRIDINE DERIVATIVE;

ACUTE KIDNEY FAILURE; ARTICLE; BLOOD PRESSURE REGULATION; CLINICAL TRIAL; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CONTRAINDICATION; DRUG COST; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG ELIMINATION; DRUG HALF LIFE; DRUG INDICATION; DRUG MECHANISM; DRUG MEGADOSE; DRUG METABOLISM; DRUG SAFETY; DRUG STRUCTURE; DRUG WITHDRAWAL; FEVER; HEADACHE; HEART ATRIUM FIBRILLATION; HEART SURGERY; HUMAN; HYPERTENSION; NAUSEA; NONHUMAN; THORAX PAIN; UNSPECIFIED SIDE EFFECT; VOMITING; ANIMAL; BLOOD PRESSURE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ANTIHYPERTENSIVE AGENTS; ATRIAL FIBRILLATION; BLOOD PRESSURE; CALCIUM; CALCIUM CHANNEL BLOCKERS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYPERTENSION; KIDNEY FAILURE, ACUTE; PYRIDINES;

EID: 67549093680     PISSN: 10615377     EISSN: None     Source Type: Journal    
DOI: 10.1097/CRD.0b013e31819fe23c     Document Type: Article

References (17)

1. Varon J. Treatment of acute severe hypertension. Current and newer agents. Drugs. 2008;68:283-297.
2. Varon J, Marik PE. Perioperative hypertension management. Vasc Health Risk Manag. 2008;4:615- 627.
3. Chobanian AV, Bakris GL, Black HR, et al. The seventh report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure. JAMA. 2003;289:2560 -2572.
4. Pollack CV, Varon J, Garrison NA, et al. Clevidipine, an intravenous dihydropyridine calcium channel blocker, is safe and effective for the treatment of patients with acute severe hypertension. Ann Emerg Med. 2008;25: 1-11.
5. Aronson S, Dyke CM, Stierer KA, et al. The ECLIPSE trials: comparative studies of clevidipine to nitroglycerin, sodium nitroprusside, and nicardipine for acute hypertension treatment in cardiac surgery patients. Anesth Analg. 2008;107:1110 -1121.
6. Levy JH, Mancao MY, Gitter R, et al. Clevidipine effectively and rapidly controls blood pressure preoperatively in cardiac surgery patients: the results of the randomized, placebo-controlled efficacy study of clevidipine assessing its preoperative antihypertensive effect in cardiac surgery-1 (ESCAPE-1). Anesth Analg. 2007;105:918 -925.
7. Singla N, Warltier DC, Ganghi SD, et al. Treatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2), a randomized, double-blind, placebo-controlled trial. Anesth Analg. 2008;107:59-67.
8. Nordlander M, Sjoquist P, Ericsson H, et al. Pharmacodynamic, pharmacokinetic and clinical effects of clevidipine, an ultrashort-acting calcium antagonist for rapid blood pressure control. Cardiovasc Drug Rev. 2004;22:227-250.
9. 2+ channel blocker. Expert Opin Investig Drugs. 2007;16:1449 -1457.
10. Gourine A, Gonon A, Sjoquist P, et al. Short-acting calcium antagonist clevidipine protects against reperfusion injury via local nitric oxide-related mechanisms in the jeopardized myocardium. Cardiovascular Res. 2001;51: 100-107.
11. Cleviprex (Clevidipine butyrate injectable emulsion) [package insert]. Clayton, NC: Hospira; 2008.
12. Noviawaty I, Uzun G, Qureshi AI. Drug evaluation of clevidipine for acute hypertension. Expert Opin Pharmacother. 2008;9:2519 -2529.
13. Keiler-Jensen N, Jolin-Mellgard A, Nordlander M, et al. Coronary and systemic hemodynamic effects of clevidipine, an ultra-short-acting calcium antagonist, for treatment of hypertension after coronary artery surgery. Acta Anaesthesiol Scand. 2000;44:186 -193.
14. Powroznyk AVV, Vuylsteke A, Naughton C, et al. Comparison of clevidipine with sodium nitroprusside in the control of blood pressure after coronary artery surgery. Eur J Anaesthesiol. 2003;20:697-703.
15. Bailey JM, Lu W, Levy JH, et al. Clevidipine in adult cardiac surgical patients. Anesthesiology. 2002;96:1086 -1094.
16. Clevidipine in the treatment of patients with acute hypertension and intracerebral hemorrhage (ACCELERATE). Available at: ClinicalTrials.gov/ct2/ show/NCT00666328. Accessed September 23, 2008.
17. Clevidipine (Cleviprex) for IV treatment of severe hypertension. Med Lett Drugs Ther. 2008;50:73-74.