Nicotinic agonist binding site mapped by methionine- and tyrosine-scanning coupled with azidochloropyridinyl photoaffinity labeling

Journal of Medicinal Chemistry

Volumn 52, Issue 12, 2009, Pages 3735-3741

  Tomizawa, Motohiro ^a   Talley, Todd T ^b   Park, John F ^b   Maltby, David ^c   Medzihradszky, Katalin F ^c   Durkin, Kathleen A ^d   Cornejo Bravo, Jose M ^b,e   Burlingame, Alma L ^c   Casida, John E ^a   Taylor, Palmer ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSIDAD AUTÓNOMA DE BAJA CALIFORNIA   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZIDO 6 CHLOROPYRIDIN 3 YL DERIVATIVE; ACETYLCHOLINE; AMINO ACID; AZIDE; AZIDOEPIBATIDINE; BINDING PROTEIN; CHLORINE DERIVATIVE; EPIBATIDINE; INSECTICIDE; METHIONINE; NEONICOTINOID; NICOTINIC AGENT; NICOTINIC RECEPTOR; NICOTINOID; PYRIDINE DERIVATIVE; TOXIC SUBSTANCE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATION; CONFORMATIONAL TRANSITION; DERIVATIZATION; LIGAND BINDING; MOLECULAR DOCKING; MOLLUSC; MUTANT; NONHUMAN; PHOTOAFFINITY LABELING; PROTEIN DOMAIN; SITE DIRECTED MUTAGENESIS;

ANIMALS; APLYSIA; AZIDES; BINDING SITES; COMPUTER SIMULATION; MASS SPECTROMETRY; METHIONINE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PHOTOAFFINITY LABELS; PYRIDINES; RECEPTORS, NICOTINIC; TYROSINE;

EID: 67549084531     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900153c     Document Type: Article

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