Hypercalcemia: An evidence-based approach to clinical cases

Iranian Journal of Kidney Diseases

Volumn 3, Issue 2, 2009, Pages 71-79

  Assadi, Farahnak ^a,b  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b Rush Children's Hospital and Rush University Medical Center   (United States)

Author keywords

Diagnosis; Hypercalcemia; Hypoalbuminemia; Neoplasms; Parathyroid hormone related protein; Primary hyperparathyroidism; Vitamin D

Indexed keywords

CALCITONIN; CALCIUM ION; CHLORIDE; FUROSEMIDE; GLUCOCORTICOID; INFUSION FLUID; LOOP DIURETIC AGENT; PAMIDRONIC ACID; PARATHYROID HORMONE; STEROID; VITAMIN D; ZOLEDRONIC ACID;

ARTICLE; CALCIUM ABSORPTION; CALCIUM BLOOD LEVEL; CALCIUM EXCRETION; CALCIUM SIGNALING; CHLORIDE BLOOD LEVEL; CLINICAL FEATURE; CLINICAL STUDY; DIALYSIS; DIFFERENTIAL DIAGNOSIS; EVIDENCE BASED MEDICINE; GASTROINTESTINAL SYMPTOM; HEART FAILURE; HUMAN; HYPERCALCEMIA; HYPERCHLOREMIC ACIDOSIS; HYPERPARATHYROIDISM; HYPERVOLEMIA; KIDNEY FAILURE; MALIGNANT NEOPLASTIC DISEASE; METABOLIC ACIDOSIS; NEPHROLITHIASIS; PARATHYROID HORMONE RELEASE; PATHOGENESIS; PRIMARY HYPERPARATHYROIDISM; REHYDRATION;

ANTI-INFLAMMATORY AGENTS; DIURETICS; EVIDENCE-BASED MEDICINE; FLUID THERAPY; FUROSEMIDE; HUMANS; HYPERCALCEMIA; HYPERPARATHYROIDISM; NEOPLASMS;

EID: 67449149974     PISSN: 17358582     EISSN: 17358604     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. Inzucchi SE. Understanding hypercalcemia. Its metabolic basis, signs, and symptoms. Postgrad Med. 2004;115:89-70.
2. Shane E, Dinaz I. Hypercalcemia; pathogenesis, clinical manifestations, differential diagnosis, and management. In: Favus MJ, editor. Primer on the metabolic bone diseases and disorders of mineral metabolism. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2006. p. 176-89.
3. Shek CC, Natkunam A, Tsang V, Cockram CS, Swaminathan R. Incidence, causes and mechanism of hypercalcaemia in a hospital population in Hong Kong. Q J Med. 1990;77:1277-85.
4. Payne RB, Little AJ, Williams. RB, Milner Jr. Interpretation of serum calcium in patients with abnormal serum proteins. BMJ. 1973;4:643-6.
5. Lafferty FW. Differential diagnosis of hypercalcemia. J Bone Miner Res. 1991;6 Suppl 2:S51-9.
6. Agus ZS. Relationship between total and ionized plasma calcium concentration. In: Rose BD, editor. Uptodate. Wellesley: 2008; 16(2). [CD-ROM].
7. Levi M, Ellis MA, Bed T. Control of renal hemodynamics and glomerular filtration rate in chronic hypercalcemia. Role of prostaglandins, renin-angiotensin system, and calcium. J Clin Invest. 1983;71:1624-32.
8. Burtis WJ, Wu TL, Insogna KL, Stewart AF. Humoral hypercalcemia of malignancy. Ann Intern Med. 1988;108:454-7.
9. Stewart AF, Adler M, Byers CM, Segre GV, Broadus AE. Calcium homeostasis in immobilization: an example of resorptive hypercalciuria. N Engl J Med. 1982;306:1136-40.
10. Ratcliffe WA, Hutchesson AC, Bundred NJ, Ratcliffe JG. Role of assays for parathyroid-hormone-related protein in investigation of hypercalcaemia. Lancet. 1992;339:164-7.
11. Jacobus CH, Holick MF, Shao Q, et al. Hypervitaminosis D associated with drinking milk. N Engl J Med. 1992;326:1173-7.
12. Beall DP, Scofield RH. Milk-alkali syndrome associated with calcium carbonate consumption. Report of 7 patients with parathyroid hormone levels and an estimate of prevalence among patients hospitalized with hypercalcemia. Medicine (Baltimore). 1995;74:89-96.
13. Nielsen J, Hoffert JD, Knepper MA, Agre P, Nielsen S, Fenton RA. Proteomic analysis of lithium-induced nephrogenic diabetes insipidus: mechanisms for aquaporin 2 down-regulation and cellular proliferation. Proc Natl Acad Sci U S A. 2008; 105:3634-9.
14. Lemann J, Jr., Gray RW, Maierhofer WJ, Cheung HS. Hydrochlorothiazide inhibits bone resorption in men despite experimentally elevated serum 1,25-dihydroxyvitamin D concentrations. Kidney Int. 1985;28:951-8.
15. Alikhan Z, Singh A. Hyperthyroidism manifested as hypercalcemia. South Med J, 1996;10:997-8.
16. Zeimer NJ, Greenaway TM, Slavin J, et al. Parathyroid-hormone-related protein in sarcoidosis. Am J Pathol. 1998;152:17-21.
17. Montoli A, Colussi G, Minetti L. Hypercalcaemia in Addison's disease: calciotropic hormone profile and bone histology. J Intern Med. 1992;232:535-40.
18. Akmal M, Bishop JE, Telfer N, Normah AW, Massry SG. Hypocalcemia and hypercalcemia in patients with rhabdomyolysis with and without acute renal failure. J. Clin Endocrinol Metab. 1986;63:137-42.
19. Heath H, 3rd. Familial benign (hypocalciuric) hypercalcemia. A troublesome mimic of mild primary hyperparathyroidism. Endocrinol Metab Clin North Am. 1989;18:723-40.
20. Heath H, 3rd. Clinical spectrum of primary hyperparathyroidism: evolution with changes in medical practice and technology. J Bone Miner Res. 1991;6 Suppl 2:S63-70; discussion S83-4.
21. Roberts WC, Waller BF. Effect of chronic hypercalcemia on the heart. An analysis of 18 necropsy patients. Am J Med. 1981;71:371-84.
22. Bilezikian JP. Management of acute hypercalcemia. N Engl J Med. 1992;326:1196-203.
23. Hosking DJ, Cowley A, Bucknall CA. Rehydration in the treatment of severe hypercalcaemia. Q J Med. 1981;50:473-81.
24. Wisneski LA. Salmon calcitonin in the acute management of hypercalcemia. Calcif Tissue Int. 1990;46 Suppl:S26-30.
25. Ljunghall S. Use of clodronate and calcitonin in hypercalcemia due to malignancy. Recent Results Cancer Res. 1989;116:40-5.
26. Major P, Lortholary A, Hon J, et al. Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: a pooled analysis of two randomized, controlled clinical trials. J Clin Onool. 2001;19:558-67.
27. Koo WS, Jeon DS, Ahn SJ, Kim YS, Yoon YS, Bang BK. Calcium-free hemodialysis for the management of hypercalcemia. Nephron. 1996;72:424-8.
28. Assadi F. Clinical decisions in pediatric nephrology: a problem-solving approach to clinical cases. New York: Springer, 2008. p. 97-124.
29. Berl T. The cAMP system in vasopressin-sensitive nephron segments of the vitamin D-treated rat. Kidney Int. 1987;31:1065-71.
30. Diercks DB, Shumaik GM, Harrigan RA, Brady WJ, Chan TC. Electrocardiographic manifestations: electrolyte abnormalities. J Emerg Med. 2004;27:153-60.
31. Wilson KS, Alexander S, Chisholm IA. Band keratopathy in hypercalcemia of myeloma. Can Med Assoc J. 1982;126:1314-5.
32. Lins LE. Reversible renal failure caused by hypercalcemia. A retrospective study. Acta Med Scand. 1978;203:309-14.
33. Caruana RJ, Buckalew VM, Jr. The syndrome of distal (type 1) renal tubular acidosis. Clinical and laboratory findings in 58 cases. Medicine (Baltimore). 1988;67:84-99.
34. Insogna KL, Dreyer BE, Mitnick M, Ellison AF, Broadus AE. Enhanced production rate of 1,25-dihydroxyvitamin D in sarcoidosis. J Clin Endocrinol Metab. 1988;66:72-5.
35. Kogan BA, Konnak JW, Lau K. Marked hyperoxaluria in sarcoidosis during orthophosphate therapy. J Urol. 1982;127:339-40.
36. Ohrvall U, Akerstrom G, Ljunghall S, Lundgren E, Jühlin C, Rastad J. Surgery for sporadic primary hyperparathyroidism in the elderly. World J Surg. 1994;18:612-8.
37. Jacobson MA, Gambertoglio JG, Aweeka FT, Causey DM, Portale AA. Foscamet-induced hypocalcemia and effects of foscamet on calcium metabolism. J Clin Endocrinol Metab. 1901;72:1130-5.