Elements of the Endotoxin Theory of Human Physiology and Pathology

Human Physiology

Volumn 29, Issue 4, 2003, Pages 476-486

  Yakovlev, M Yu ^a  

^a Institute of General and Clinical Pathology   (Russian Federation)

Author keywords

Blood Flow; Common Factor; Human Disease; Human Physiology; Immune System

Indexed keywords

EID: 67449140513     PISSN: 03621197     EISSN: 16083164     Source Type: Journal    
DOI: 10.1023/A:1024989709554     Document Type: Article

References (75)

1. Pfeiffer, R., Untersuchungen uber das Choleragift, Z. Hygiene, 1892, vol. 11, p. 393.
2. Wolff, M., Beitrage zur Immunitatslehre (Contributions to the Teaching of Immunity), Zentralbl. Bakteriol. Parasit. Infekt. Hyg. I. Org., 1904, vol. 37, p. 390.
3. Handbook of Endotoxin, Amsterdam, 1984.
4. Westphal, O., Luderitz, O., Galanos, C., Mayer, H., and Reitschel, E.T., The Story of Endotoxin, Proc. 3rd Int. Conference on Advances in Immunopharmacology, 1975, p. 13.
5. Yakovlev, M.Yu., The Role of Intestinal Flora and Insufficiency of the Liver Barrier Function in the Development of Endotoxinemia and Inflammation, Kazan. Med. Zh., 1988, no. 5, p. 353.
6. Yakovlev, M.Yu., Systemic Endotoxinemia in Human Physiology and Pathology, Abstract of Doctoral (Med.) Dissertation, Moscow, 1993.
7. Yakovlev, M.Yu., Elements of Endotoxin Theory of Human Physiology and Pathology: “Systemic Endotoxinemia,” Endotoxin Aggression and Endotoxin Insufficiency, J. Endotoxin Res., 2000, vol. 6, no. 2, p. 120.
8. Yakovlev, M.Yu., Elements of Endotoxin Theory of Human Physiology and Pathology: “Systemic Endotoxinemia,” “Endotoxin Aggression” and “Endotoxin Insufficiency,” Bull. CDS Moscow-Paris, 2000, vol. 2, p. 5.
9. Bel'chik, Yu.F., Correction of Impaired Antiendotoxin Immunity in Purulent Inflammatory Diseases in Full-Term Newborns, Abstract of CAnd. Sci. (Med.) Dissertation, Moscow, 1998.
10. Tabolin, V.A., Bel'chik, Yu.F., Chabaidze, Zh.L., and Yakovlev, M.Yu., Parameters of Antiendotoxin Immunity in Normal Newborns and Newborns with Infections, Int. J. Immunorehabilit., 2000, vol. 2, no. 1, p. 133.
11. Urazaev, R.A., Krupnik, A.N., and Yakovlev, M.Yu., Endotoxinemia during the Early Adaptation Period in Newborns and Their Mothers, Kazan. Med. Zh., 1992, no. 2, p. 114.
12. Likhoded, V.G., Anikhovskaya, I.A., Apollonin, A.V., Kozlova, N.N., Kudryavtsev, A.E., Khabriev, R.U., Yushchuk, N.D., and Yakovlev, M.Yu., Fc-Dependent Binding of Endotoxins of Gram-negative Bacteria by Polymorphonuclear Leukocytes of Human Blood, Zh. Mikrobiol., 1996, no. 2, p. 76.
13. Permyakov, N.K., Anikhovskaya, I.A., Krupnik, A.N., Likhoded, V.G., and Yakovlev, M.Yu., Immune Morphological Estimation of the Reserve of Endotoxin Binding by Polymorphonuclear Leukocytes, Arkh. Patol., 1995, no. 2, p. 4.
14. Endotoxin in Health and Disease, Brade, H., Opal, S.M., Vogel, S.N., and Morrison, D.C., Eds., New York, 1999.
15. Likhoded, V.G., Yushchuk, N.D., and Yakovlev, M.Yu., The Role of the Endotoxin of Gram-negative Bacteria in Infectious and Noninfectious Pathology, Arkh. Patol., 1996, no. 2, p. 8.
16. Zubairov, D.M., Biokhimiya svertyvaniya krovi (The Biochemistry of Blood Coagulation), Moscow: Meditsina, 1978.
17. Salachov, I.M., Ipatov, A.I., Konev, Yu.V., and Yakovlev, M.Yu., Modern Aspects of the Pathogenesis of Endotoxin Shock, Usp. Sovrem. Bio l., 1998, vol. 118, no. 1, p. 33.
18. Sarkisov, D.S., Ocherki istorii obshchei patologii (Essays on the History of General pathology), Moscow: Meditsina, 1994.
19. Permyakov, N.K., Yakovlev, M.Yu., and Galankin, V.G., Endotoxin and the System of Polymorphonuclear Leukocyte, Arkh. Patol., 1989, no. 5, p. 3.
20. Yakovlev, M.Yu., Galankin, V.N., Krupnik, A.N., and Tokmakov, A.M., The Lipopolysaccharide of Intestinal Flora in the Physiology and Pathology of the System of Polymorphonuclear Leukocyte, in Sbornik nauchnykh trudov NII morfologii cheloveka AMN SSSR (Collection of Works of the Research Institute of Human Morphology of the Academy of Medical Sciences of the Soviet Union), Moscow, 1989, p. 74.
21. Yakovlev, M.Yu., Kubatiev, A.A., Krupnik, A.N., Bondarenko, V.M., and Sudzhan, E.V., Eosinophilic Leukocyte Is a Blood Cell Superaffine to Endotoxin, Byull. Exp. Biol. Med., 1989, no. 6, p. 765.
22. Alexander, Ch. and Rietschel, E. Bacterial Lipopolysaccharides and Innate Immunity, J. Endotoxin Research, 2001, vol. 7, no. 3, p. 167.
23. Anikhovskaya, I.A., Estimation of the State of Health form the Parameters of Humoral Immunity to the Endotoxin of Gram-negative Bacteria, in Topical Issues of Human Pathology, Moscow, 2001.
24. Anikhovskaya, I.A., Detection of Risk Groups, Choice of Examination Strategy, and Evaluation of the Effectiveness of Treatment of Various Diseases on the Basis of the Parameters of Antiendotoxin Immunity, Abstract of Cand. Sci. (Med.) Dissertation, Moscow, 2001.
25. Anokhin, V.A., The Pathogenetic Significance of Endotoxinemia and Changes in the Activity of Antiendotoxin Defense in Children with Acute Respiratory Viral Infections, Abstract of Doctoral (Med.) Dissertation, Moscow, 1994.
26. Anokhin, V.A., Bulatova, G.R., Krupnik, A.N., and Yakovlev, M.Yu., Systemic Endotoxinemia and Bronchus Obstruction Syndrome in Acute Respiratory Viral Infection, Kazan. Med. Zh., 1992, no. 2, p. 8.
27. Akhmina, N.I., Perinatal Health Care for Infants with Constitutional Predisposition to Diseases, Abstract of Doctoral (Med.) Dissertation, Moscow, 2000.
28. Galuev, M.M., Estimation of the Severity of Infectious Toxicosis on the Basis of the Screening Diagnostic Endotoxin Test System SOIS-IEA, in Topical Issues of Human Pathology, Moscow, 2001.
29. Ipatov, A.I., Novikova, I.G., Anikhovskaya, I.A., Markelova, N.V., Orlov, L.L., Salachov, I.M., and Yakovlev, M.Yu., The Relationship of the State of Antiendotoxin Immunity with Some Peripheral Hemodynamic Parameters in Patients with Acute Myocardial Infarction, Med. Zh. Ross., 1998, no. 1/2, p. 149.
30. Kogan, L.G., Hyperendotoxinemia in Dysbioses Caused by Antibiotic Therapy and Its Correction with Protobiotics in Geriatric Practice, Abstract of Cand. Sci. Dissertation, Moscow, 2000.
31. Konev, Yu.V., Systemic Endotoxinemia: Clinical and Pathogenetic Characteristics of CHD and Atherosclerosis in Elderly Persons, Abstract of Doctoral (Med.) Dissertation, Moscow, 1997.
32. Lykova, E.A., Bondarenko, V.M., Vorob'ev, A.A., Sulzhan, E.V., and Minaev, V.I., Bacterial Endotoxinemia in Children with Intestinal Dysbiosis, Zh. Mikrobiol., 1999, no. 3, p. 67.
33. Malov, V.A., Likhoded, V.G., Apollonin, A.V., and Karlychev, Ch., The State of Some Humoral Antiendotoxin Systems in Patients with Acute Intestinal Infections, Ter. Arkh., 1993, no. 11, p. 7.
34. Meshlov, M.V., The Role of Insufficiency of the Humoral Component of Antiendotoxin Immunity in Homeostasis Disturbances and Postoperative Complications in Children, in Aktual'nye voprosy patologii cheloveka (Topical Issues of Human Pathology), Moscow, 2001, p. 97.
35. Novikova, I.G., The State of Peripheral Hemodynamics and Its Relationship with Antiendotoxin Immunity in Patients with Acute Myocardial Infarction, Abstract of Cand. Sci. (Med.) Dissertation, Moscow, 1998.
36. Rudik, A.A., Apollonin, A.V., Kropacheva, E.I., and Likhoded, V.G., Effect of UV Light on the Protective Activity of Donor Blood Plasma with High Antibody Content, Zh. Mikrobiol., 1992, vos. 11-12, p. 59.
37. Salachov, I.M., Parameters of Antiendotoxin Immunity in Experimental Endotoxin Shock, in Aktual'nye voprosy patologii cheloveka (Topical Issues of Human Pathology), Moscow, 2001, p. 110.
38. Sozinov, A.V., Systemic Endotoxinemia and Parameters of Humoral Antiendotoxin Immunity in Chronic Viral Hepatites, in Aktual'nye voprosy patologii cheloveka (Topical Issues of Human Pathology), Moscow, 2001, p. 113.
39. Trishina, N.V., Relationship between the State of Anti-endotoxin Immunity and Intestinal Dysbacteriosis, in Aktual'nye voprosy patologii cheloveka (Topical Issues of Human Pathology), Moscow, 2001, p. 116.
40. Chemlev, A.V., Akhmina, N.I., Bel'chik, Yu.F., Efimov, M.S., Upazaev, R.A., Chabaide, Zh.L., and Yakovlev, M.Yu., Prognostic Significance of the Parameters of Antiendotoxin Immunity in Severe Bacterial Infection, CNS Disorders, and Intestinal Syndrome in Infants under One Month of Age, Med. Zh. Ross., 1998, no. 1/2, p. 144.
41. Chizhikov, N.V., Parameters of Systemic Endotoxinemia and Antiendotoxin Immunity in Chronic Ischemia of Lower Extremities in Elderly Patients, in Aktual'nye voprosy patologii cheloveka (Topical Issues of Human Pathology), Moscow, 2001, p. 126.
42. Chabaidze, Zh.L., Clinical and Epidemiological Characteristics of Herpes Viral Infection and Its Relationship with Antiendotoxin Immunity in Newborns, Abstract of Cand. Sci. (Med.) Dissertation, Moscow, 2000.
43. Yakovlev, M.Yu., Likhoded, V.G., Anikhovskaya, I.A., Maiskaya, S.A., Salachov, I.M., Urazaev, R.A., and Shakhlamov, A.V., The Use of the Parameters of Antiendotoxin Immunity for Objective Evaluation of Individual Resistance and the Effectiveness of Therapy, Med. Zh. Ross., 1998, no. 1/2, p. 139.
44. Anikhovskaya, I. and Yakovlev, M., Screening Endotoxin Test System “SOIS-IFA” in Differential Diagnostics of Latent Diseases, J. Endotoxin Res., 2000, vol. 6, no. 2, p. 120.
45. Chmililovich, A.A., Anikhovskaya, I.A., Salachov, I.M., and Yakovlev, M.Yu., Participation of Endotoxin in the Pathogenesis of Schizophrenia, Bull. CDS Moscow- Paris, 2000, vol. 2, p. 9.
46. Sozinov, A.S., Tkacheva, S.V., Anikhovskaya, I.A., Zinkevich, O.D., Salachov, I.M., Safina, N.A., and Yakovlev, M.Yu., Relation of Endotoxinemia Indices and Clinico-Laboratory Features in Patients with Chronical Virus Hepatitis, Bull. CDS Moscow-Paris, 2000, vol. 2, p. 8.
47. Sarkisov, D.S., Pal'tsyn, A.A., and Vtyurin, B.V., Prisposobitel'naya perestroika bioritmov (Adaptive Rearrangement of Biorhythms), Moscow: Meditsina, 1975.
48. Yakovlev, M.Yu., Endotoxin-Induced Shock, Kazan. Med. Zh., 1987, no. 3, p. 207.
49. Yakovlev, M.Yu., Functional Morphology of Myocardium in Experimental Toxic Infectious Shock, Abstract of Cand. Sci. (Med.) Dissertation, Moscow, 1980.
50. Permyakov, N.K. and Yakovlev, M.Yu., The Heart in Endotoxin-Induced Shock, Pat. Fiziol. Eksp. Ter., 1990, no. 2, p. 45.
51. Permyakov, N.K., Yakovlev, M.Yu., Krupnik, A.N., and Kubatiev, A.A., The Role of Transitory Coronary Spasm in the Genesis of Myocardial Infarction, Byull. Eksp. Biol. Med., 1989, no. 7, p. 121.
52. Chizhikov, N.V., Anikhovskaya, I.A., Likhoded, V.G., Salachov, I.M., and Yakovlev, M.Yu., The Role of Systemic Endotoxinemia in the Pathogenesis of Atherosclerosis, Usp. Sovrem. Biol., 2001, vol. 121, no. 3, p. 266.
53. Yakovlev, M.Yu., Metabolic Heterogeneity of the Myocardium and the Phenomenon of Centralization of Blood Flow in the Muscle of Heart in Endotoxin Shock, Vestn. Akad. Med. Nauk SSSR, 1981, no. 5, p. 26.
54. Yakovlev, M.Yu., Myocardium Morphology in Endotoxin Shock, Arkh. Patol., 1985, no. 7, p. 34.
55. Yakovlev, M.Yu., Likhoded, V.G., Anikhovskaya, I.A., Konev, Yu.V., and Permyakov, N.K., Endotoxin-Induced Damage of the Endothelium, Arkh. Patol., 1996, no. 2, p. 41.
56. Chizhikov, N.V., The Role of Endotoxin Aggression in the Pathogenesis and Clinical Characteristics of Progressive Chronic Ischemia of Lower Extremities in Elderly Persons, Abstract of Doctoral (Med.) Dissertation, Moscow, 2002.
57. Chizhikov, N.V., Likhoded, V.G., Svetukhin, A.M., and Yakovlev, M.Yu., Endotoksin kishechnoi mikroflory v klinike i patogeneze khronicheskoi ishemii nizhnikh konechnostei (The Role of Endotoxin of Intestinal Flora in the Clinical Characteristics and Pathogenesis of Chronic Ischemia of Lower Extremities), Penza, 2002.
58. Gianotti, L., Alexander, J.W., Pyles, T., Fukushima, R., and Babcock, G.R., Prostaglandin E1 Analogs Micro-prostol and Enisoprost Decrease Microbial Translocation and Modulate the Immune Response, Circ. Shock, 1993, vol. 40, p. 243.
59. Fukushima, R., Gianotti, L., Alexander, J.W., and Pyles, T., The Degree of Bacterial Translocation Is a Determinant for Mortality after Burn Injury and Is Improved by Prostaglandin Analogs, Ann. Surg., 1992, vol. 216, p. 438.
60. Rabi, K., Loklizovannaya i rasseyannaya vnutrisosudistaya koagulyatsiya (Localized and Disseminated Intra-vascular Coagulation), Moscow: Meditsina, 1974.
61. Permyakov, N.K. and Yakovlev, M.Yu., Pathology of Digestive Organs and Systemic Endotoxinemia, Arkh. Patol., 1989, no. 12, p. 74.
62. Permyakov, N.K., Yakovlev, M.Yu., and Mironyuk, A.A., The Role of Intestinal Endotoxin in Liver Pathology, Arkh. Patol., 1989, no. 9, p. 3.
63. Permyakov, N.K., Yakovlev, M.Yu., and Shlyapnikov, V.V., Acute Kidney Failure (The Involvement of Endotoxin in the Pathogenesis), Pat. Fiziol. Eksp. Ter., 1989, no. 6, p. 77.
64. Sitdykov, E.N., Krupnik, A.N., Sitdykova, M.E., and Yakovlev, M.Yu., Iatrogenic Conditions in Urology, Arkh. Patol., 1988, no. 5, p. 31.
65. Yakovlev, M.Yu., Zubairova, L.D., Krupnik, A.N., Permyakov, N.K., The Role of Alveolar Macrophages in Lung Physiology and Pathology, Arkh. Patol., 1991, no. 4, p. 3.
66. Yakovlev, M.Yu., Galankin, V.N., Ipatov, A.I., Anykina, N.V., and Kryukov, N.O., Acute Respiratory Distress Syndrome, Arkh. Patol., 1988, no. 11, p. 81.
67. Michel, O., Ginanni, R., Duchateau, J., Vertongen, F., and Le Bon, B., Domestic Endotoxin Exposure and Clinical Severity of Asthma, Exp. Allergy, 1991, vol. 21, no. 4, p. 441.
68. Permyakov, N.K., Generalized Purulent Infection after Induced Abortions, Abstract of Doctoral (Med.) Dissertation, Moscow, 1958.
69. Likhoded, V.G., Gremyakova, T.A., Poverennyi, A.M., Korogodin, D.V., Nasonov, E.L., and Nasonova, V.A., Proteins Binding the Re-chemotype Glycolipid of Salmonella minnesota R 595 in the Blood Serum of Patients with Lupus Erythematosus and Rheumatoid Arthritis, Immunologiya, 1984, no. 6, p. 61.
70. Dmitrieva, E.V., Apollonin, A.V., Likhoded, V.G., Yakovlev, M.Yu., Volchkova, E.V., Malov, V.A., and Pak, S.G., Functional Activity of Antiendotoxin Factors in Viral Hepatites A and B, Vestn. Ross. Akad. Med. Nauk, 1995, no. 12, p. 38.
71. Lysova, N.L., Pathological Morphological Characterization of Liver Acini in Systemic Endotoxinemia and Endotoxin Shock, Abstract Cand. Sci. (Med.) Dissertation, Moscow, 2000.
72. Salachov, I.M., Sozinov, A.S., Abdulkhakov, S.R., Kiyasov, A.P., Lysova, N.L., and Yakovlev, M.Yu., Single Endotoxin Aggression Induces Dose-Independent Reversible Activation of Ito Cells of the Rat Liver without Their Transdifferentiation into Myofibroblasts, Byull. Eksp. Biol. Med., 2000, no. 10, p. 449.
73. Apollonin, A.V., Yakovlev, M.Yu., Rudik, A.A., and Likhoded, V.G., Endotoxin-Binding Systems of the Blood, Zh. Mikrobiol., 1990, no. 1, p. 45.
74. Glad'ko, I.A., Pinegin, B.V., Korshunov, V.M., Apollonin, A.V., and Likhoded, V.G., The Effect of Active Immunization on Intestinal Flora in Dysbacteriosis, Immunologiya, 1983, no. 2, p. 56.
75. Vestnik Kliniko diagnosticheskogo obshchestva (Herald of the Clinical Diagnostic Society), Moscow, 2002, issue 3.