In vivo MR spectroscopic imaging of polyunsaturated fatty acids (PUFA) in healthy and cancerous breast tissues by selective multiple-quantum coherence transfer (Sel-MQC): A preliminary study

Magnetic Resonance in Medicine

Volumn 58, Issue 6, 2007, Pages 1079-1085

  He, Qiuhong ^a,c   Shkarin, Pavel ^b   Hooley, Regina J ^b   Lannin, Donald R ^b   Weinreb, Jeffrey C ^b   Bossuyt, Veerle Ilse Julie ^b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Breast cancer; Magnetic resonance spectroscopy; MRSI; Polyunsaturated fatty acids; PUFA; Sel MQC

Indexed keywords

DIAGNOSIS; DISEASES; HISTOLOGY; MAGNETIC RESONANCE; MAGNETIC RESONANCE SPECTROSCOPY; POLYUNSATURATED FATTY ACIDS; QUANTUM THEORY; TISSUE; ULTRASONIC APPLICATIONS;

BREAST CANCER; INVASIVE DUCTAL CARCINOMATA; MAGNETIC RESONANCE SPECTROSCOPIC IMAGING; MALIGNANT TRANSFORMATIONS; MRSI; MULTIPLE-QUANTUM COHERENCES; PUFA; SEL-MQC;

MEDICAL IMAGING;

CARBENE; POLYUNSATURATED FATTY ACID; PROTON;

ARTICLE; BREAST CANCER; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HISTOLOGY; HUMAN; MAMMOGRAPHY; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; SELECTIVE MULTIPLE QUANTUM COHERENCE TRANSFER; ULTRASOUND;

EID: 36849048182     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.21335     Document Type: Article

References (30)

1. Knopp MV, Weiss E, Sinn HP, Mattern J, Junkermann H, Radeleff J, Magener A, Brix G, Delorme S, Zuna I, van Kaick G. Pathophysiologic basis of contrast enhancement in breast tumors. J Magn Reson Imaging 1999;10:260-266.
2. Choyke PL, Knopp V, Libutti SK. Special techniques for imaging blood flow to tumors. Cancer J 2002;8:109-118.
3. Kuhl CK, Mielcareck P, Klaschik S, Leutner C, Wardelmann E, Gieseke J, Schild HH. Dynamic breast MR imaging: are signal intensity time course data useful for differential diagnosis of enhancing lesions? Radiology 1999;211:101-110.
4. Schnall MD, Rosten S, Englander S, Orel SG, Nunes LW. A combined architectural and kinetic interpretation model for breast MR images. Acad Radiol 2001;8:591-597.
5. Nunes LW, Schnall MD, Orel SG. Update of breast MR imaging architectural interpretation model. Radiology 2001;219:484-494.
6. 31P-NMR studies of cells and tumors. Magn Reson Mater Phys Biol Med 1998;6:44-52.
7. Roebuck JR, Cecil KM, Schnall MD, Lenkinski RE. Human breast lesions: characterization with proton MR spectroscopy. Radiology 1998;209:269-275.
8. Jagannathan N, Kumar M, Seenu V, Coshic O, Dwivedi SN, Julka PK, Srivastava A, Rath GK. Evaluation of total choline from in vivo volume localized proton MR spectroscopy and its response to neoadjuvant chemotherapy in locally advanced breast cancer. Br J Cancer 2001;84:1016-1022.
9. 1H MR spectroscopy - a pilot study at 4 T. Radiology 2004;233:424-431.
10. 1H MRS at 1.5 T. Eur Radiol 2005;15:1037-1043.
11. Das UN. A radical approach to cancer. Med Sci Monit 2002;8:RA79-92.
12. Ge Y, Chen Z, Kang ZB, Cluette-Brown J, Laposata M, Kang JX. Effects of adenoviral gene transfer of C. elegans n-3 fatty acid desaturase on the lipid profile and growth of human breast cancer cells. Anticancer Res 2002;22:537-543.
13. De Graffenried LA, Friedrichs WE, Fulcher L, Fernandes G, Silva JM, Peralba J-M, Hidalgo M. Eicosapentaenoic acid restores tamoxifen sensitivity in breast cancer cells with high Akt activity. Ann Oncol 2003;14:1051-1056.
14. Das UN, Prasad VSSV, Reddy DR. Local application of gamma-linolenic acid in the treatment of human gliomas. Cancer Lett 1995;94:147-155.
15. 1H-NMR detectable fatty acyl chain unsaturation in excised leiomyosarcoma correlate with grade and mitotic activity. J Clin Invest 1996;98:244-250.
16. Thomas MA, Binesh N, Yue K, DeBruhl N. Volume-localized two-dimensional correlated magnetic resonance spectroscopy of human breast cancer. J Magn Reson Imaging 2001;14:181-186.
17. Mountford CE, Mackinnon WB, Russell P, Rutter A, Delikatny EJ. Human cancers detected by proton MRS and chemical shift imaging ex vivo. Anticancer Res 1996;16:1521-1532.
18. He Q, Shungu DC, van Zijl PCM, Bhujwalla ZM, Glickson JD. Single scan in vivo lactate editing with complete lipid and water suppression by selective multiple quantum coherance transfer (Sel-MQC) with application to tumors. J Magn Reson B 1995;106:203-211.
19. Benedetti A, Malvaldi G, Fulceri R, Comporti M. Loss of lipid peroxidation as a histochemical marker for preneoplastic hepatocellular foci of rats. Cancer Res 1984;44:5712-5717.
20. Delikatny EJ, Roman SK, Hancock R, Jeitner TM, Lander CM, Rideout DC, Mountford CE. Tetraphenylphosphonium chloride induced MR-visible lipid accumulation in a malignant human breast cell line. Int J Cancer 1996;67:72-79.
21. 1H MRS studies of signals from mobile lipids and from lipid metabolites: comparison of the behavior in cultured tumor cells and in spheroids. NMR Biomed 2004;17:76-91.
22. 1H MRS detects polyunsaturated fatty acid accumulation during gene therapy of glioma: implications for the in vivo detection of apoptosis. Nat Med 1999;5:1323-1327.
23. Mountford CE, Wright LC. Organization of lipids in the plasma membranes of malignant and stimulated cells: a new model. Trends Biochem Sci 1988;13:172-177.
24. Dvorak AM, Morgan E, Schleimer RP, Ryeom SW, Lichtenstein LM, Weller PF. Ultrastructural immunogold localization of prostaglandin endoperoxide synthase (cyclooxygenase) to non-membrane-bound cytoplasmic lipid bodies in human lung mast cells, alveolar macrophages, type II pneumocytes, and neutrophils. J Histochem Cytochem 1992;40:759-769.
25. Zhang D, Tai LK, Wong LL, Chiu L-L, Sethi SK, Koay ESC. Proteomic study reveals that proteins involved in metabolic and detoxification pathways are highly expressed in HER-2/neu-positive breast cancer. Mol Cell Proteom 2005;4:1686-1696.
26. Jagannathan NR, Singh M, Govindaraju V, Raghunathan P, Coshic O, Julka PK, Rath GK. Volume localized in vivo proton MR spectroscopy of breast carcinoma: variation of water-fat ratio in patients receiving chemotherapy. NMR Biomed 1998;11:414-422.
27. Tzika AA, Zarifi MK, Goumnerova L, Astrakas LG, Zurakowski D, Young-Poussaint T, Anthony DC, Scott RM, Black PM. Neuroimaging in pediatric brain tumors: Gd-DTPA-enhanced, hemodynamic, and diffusion MR imaging compared with MR spectroscopic imaging. Am J Neuroradiol 2002;23:322-333.
28. Muruganandham M, Koutcher JA, Pizzorno G, He Q. In vivo tumor lactate relaxation measurements by selective multiple-quantum-coherence (Sel-MQC) transfer. Magn Reson Med 2004;52:902-906.
29. Lane J, Mansel RE, Jiang WG. Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer. Int J Mol Med 2003;12:253-257.
30. Tesiram YA, Saunders D, Towner RA. Application of proton NMR spectroscopy in the study of lipid metabolites in a rat hepatocarcinogenesis model. Biochim Biophys Acta 2005;1737:61-68.