Measuring soluble forms of extracellular cytokeratin 18 identifies both apoptotic and necrotic mechanisms of cell death produced by adenoviral-mediated interferon α: PPPossible use as a surrogate marker

Cancer Gene Therapy

Volumn 16, Issue 7, 2009, Pages 567-572

  Fisher, M B ^a   Zhang, X Q ^a   McConkey, D J ^a   Benedict, W F ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Adenoviral mediated interferon a cell death; Bladder cancer; Extracellular cytokeratin 18; M30 and M65 ELISAs

Indexed keywords

ADENOVIRUS VECTOR; CYTOKERATIN 18; RECOMBINANT ALPHA2B INTERFERON;

APOPTOSIS; ARTICLE; BLADDER CANCER; BYSTANDER EFFECT; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CELL DEATH; CONTROLLED STUDY; CULTURE MEDIUM; DISEASE MARKER; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; UROTHELIUM;

ADENOVIRIDAE; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DEATH; CELL LINE, TUMOR; CULTURE MEDIA, CONDITIONED; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERFERON ALFA-2B; INTERFERON-ALPHA; KERATIN-18; NECROSIS; URINARY BLADDER NEOPLASMS;

EID: 67449136146     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2009.2     Document Type: Article

References (9)

1. Papageorgiou A, Lashinger L, Millikan R, Benedict WF, Dinney CP, McConkey DJ. Autocrine TRAIL production mediates interferon-induced apoptosis in human bladder cancer cells. Cancer Res 2004; 64: 8973-8979.
2. Benedict WF, Tao Z, Kim CS, Zhang X, Zhou JH, Adam L et al. Intravesical Ad-IFNα causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFNα protein. Mol Ther 2004; 10: 525-532.
3. Zhang X-Q, Yang Z, Dong L, Papageorgiou A, McConkey D, Benedict WF. Adenoviral-mediated interferon a overcomes resistance to the interferon protein in various cancer types and has marked bystander effects. Cancer Gene Ther 2007; 14: 241-250.
4. Zhang X-Q, Dong L, Chapman E, Benedict WF. Conditioned medium from Ad-IFNα infected bladder cancer and normal urothelial cells is cytotoxic to cancer cells but not normal cells: Further evidence for a strong bystander effect. Cancer Gene Ther 2008; 15: 817-822.
5. Cummings J, Ranson M, Butt F, Moore D, Dive C. Qualification of M30 and M65 ELISAs as surrogate biomarkers of cell death: long term antigen stability in cancer patient plasma. Cancer Chemother Pharmacol 2007; 60: 921-924.
6. Linder S. Cytokeratin markers come of age. Tumor Biol 2007; 28: 189-195.
7. Kramer G, Erdal H, Mertens MM, Nap M, Mauermann J, Steiner G et al. Differentiation between cell death modes using measurement of different soluble forms of extracellular cytokeratin 18. Cancer Res 2004; 64: 1751-1756.
8. Cummings J, Ranson M, LaCasse E, Ganganagari JR, St-Jean M, Jayson G et al. Method validation and preliminary quantification of pharmacodynamic biomarkers employed to evaluate the clinical efficacy of an antisense compound (AEG35156) targeted to the X-linked inhibitor of apoptosis protein XIAP. Br J Med 2006; 95: 42-48.
9. Chapman EJ, Hurst CD, Pitt E, Chambers P, Aveyard JS, Knowles MA. Expression of hTERT immortalizes normal human urothelial cells without inactivation of the p16/Rb pathway. Oncogene 2006; 25: 5037-5045.