Conditioned medium from Ad-IFN-α-infected bladder cancer and normal urothelial cells is cytotoxic to cancer cells but not normal cells: Further evidence for a strong bystander effect

Cancer Gene Therapy

Volumn 15, Issue 12, 2008, Pages 817-822

  Zhang, X ^a   Dong, L ^a   Chapman, E ^b   Benedict, W F ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Adenoviral mediated interferon ; Bladder cancer; Bystander effects; Conditioned medium

Indexed keywords

ADENOVIRAL MEDIATED INTERFERON ALPHA; ADENOVIRUS VECTOR; CASPASE 8; CASPASE 9; RECOMBINANT ALPHA2B INTERFERON; UNCLASSIFIED DRUG;

ARTICLE; BLADDER CANCER; BYSTANDER EFFECT; CELL CYCLE G1 PHASE; CELL TYPE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

ADENOVIRIDAE; BYSTANDER EFFECT; CASPASE 8; CASPASE 9; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; FEMALE; FLOW CYTOMETRY; HUMANS; INTERFERON-ALPHA; TEMPERATURE; TUMOR CELLS, CULTURED; URINARY BLADDER NEOPLASMS; UROTHELIUM;

EID: 56049093219     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2008.53     Document Type: Article

References (5)

1. Benedict WF, Tao Z, Kim CS, Zhang X, Zhou JH, Adam L et al. Intravesical Ad-IFN-α causes marked regression of human bladder cancer growing orthotopically in nude mice and overcomes resistance to IFN-α protein. Mol Ther 2004; 10: 525-532.
2. Zhang X-Q, Yang Z, Dong L, Papageorgiou A, McConkey D, Benedict WF. Adenoviral-mediated interferon-α overcomes resistance to the interferon protein in various cancer types and has marked bystander effects. Cancer Gene Ther 2007; 14: 241-250.
3. Chapman EJ, Hurst CD, Pitt E, Chambers P, Aveyard JS, Knowles MA. Expression of hTERT immortalises normal human urothelial cells without inactivation of the p16/Rb pathway. Oncogene 2006; 25: 5037-5045.
4. Tao Z, Connor RJ, Ashoori F, Dinney CP, Munsell M, Philopena JA et al. Intravesical adenoviral-mediated α-interferon in the presence of Syn3 causes marked regression of human bladder cancer growing orthotopically in nude mice: Correlations with dose and urine α-interferon concentrations. Cancer Gene Ther 2006; 13: 125-130.
5. Papageorgiou A, Lashinger L, Millikan R, Benedict WF, Dinney CP, McConkey DJ. Autocrine TRAIL production mediates interferon-induced apoptosis in human bladder cancer cells. Cancer Res 2004; 64: 8973-8979.