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Volumn 840, Issue 1, 2006, Pages 56-62
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LC-MS/MS assay and dog pharmacokinetics of the dimeric pyrrolobenzodiazepine SJG-136 (NSC 694501)
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Author keywords
Anticancer agents; Benzodiazepine; LC MS MS; Pharmacokinetics
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Indexed keywords
AMINES;
ASSAYS;
BIOMEDICAL ENGINEERING;
DIMERS;
DNA;
LIQUID CHROMATOGRAPHY;
MASS SPECTROMETRY;
PHASE SEPARATION;
ANTICANCER AGENTS;
BENZODIAZEPINE;
IN VITRO CYTOTOXICITY;
LC/MS/MS;
PHARMACOKINETICS;
8,8' [[(PROPANE 1,3 DIYL)DIOXY] BIS[7 METHOXY 2 METHYLIDENE 1,2,3,11A TETRAHYDRO 5H PYRROLO[2,1 C][1,4]BENZODIAZEPIN 5 ONE];
NSC 694501;
PYRROLO[2,1 C][1,4]BENZODIAZEPINE DERIVATIVE;
SJG 136;
UNCLASSIFIED DRUG;
ANIMAL EXPERIMENT;
ARTICLE;
COLUMN CHROMATOGRAPHY;
COMPARTMENT MODEL;
CONTROLLED STUDY;
DOG;
DRUG CLEARANCE;
DRUG DETERMINATION;
DRUG ELIMINATION;
DRUG HALF LIFE;
DRUG ISOLATION;
DRUG PROTEIN BINDING;
ELECTROSPRAY;
ELUTION;
HUMAN;
HUMAN VERSUS ANIMAL COMPARISON;
LIQUID CHROMATOGRAPHY;
MOUSE;
NONHUMAN;
PLASMA;
PLASMA CLEARANCE;
PLASMA HALF LIFE;
PLASMA PROTEIN BINDING;
PRIORITY JOURNAL;
QUANTITATIVE ANALYSIS;
RAT;
REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
SENSITIVITY AND SPECIFICITY;
SOLID PHASE EXTRACTION;
SPECIES COMPARISON;
TANDEM MASS SPECTROMETRY;
ANIMALS;
BENZODIAZEPINONES;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
DOGS;
HUMANS;
MASS SPECTROMETRY;
MICE;
PROTEIN BINDING;
PYRROLES;
RATS;
REFERENCE STANDARDS;
CANIS FAMILIARIS;
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EID: 33746298676
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jchromb.2006.04.031 Document Type: Article |
Times cited : (11)
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References (8)
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