Analytical study proving alprazolam degradation to its main impurity triazolaminoquinoleine through Maillard reaction

Analytical and Bioanalytical Chemistry

Volumn 394, Issue 5, 2009, Pages 1349-1359

  Huidobro, A L ^a   Barbas, C ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Alprazolam; Degradation pathway; Excipient incompatibility; Lactose; Maillard reaction; Reducing sugars; Triazolaminoquinoleine

Indexed keywords

CALCIUM CARBONATE; DEGRADATION; DRUG PRODUCTS; GLYCOSYLATION; MASS SPECTROMETRY; SUGARS;

ALPRAZOLAM; DEGRADATION PATHWAYS; EXCIPIENT INCOMPATIBILITY; LACTOSE; MAILLARD REACTION; REDUCING SUGARS; TRIAZOLAMINOQUINOLEINE;

REACTION INTERMEDIATES;

EID: 67449131501     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-008-2534-6     Document Type: Conference Paper

References (22)

1. JC Verster ER Volkerts 2004 CNS Drug Rev 10 45 76
2. NS Nudelman CG Cabrera 2002 J Pharm Sci 91 1274 1286
3. AL Huidobro FJ Rupérez C Barbas 2007 J Pharma and Biomed Anal 44 404 413
4. L Saavedra A Huidobro A García JM Cabanelas González C Barbas 2006 Electrophoresis 27 2360 2366
5. LC Maillard MA Gautier 1912 Compt Seances Acad Sci 154 66 68
6. F Ledl E Schleicher 1990 Angew Chem, Int Ed Engl 29 565 594
7. Y Hammouda SA Salakawy 1971 Pharmazie 26 636 640
8. SM Blaug W Huang 1972 J Pharm Sci 61 1770 1775
9. KJ Hartauer JK Guillory 1991 Drug Dev Ind Pharm 17 617 630
10. R Eyjolfsson 1998 Drug Dev Ind Pharm 24 797 798
11. DD Wirth SW Baertschi RA Johnson SR Maple MS Miller DK Hallenbeck SM Gregg 1998 J Pharm Sci 87 31 39
12. Z Qiu JG Stowell W Cao KR Morris SR Byrn MT Carvajal 2005 J Pharm Sci 94 2568 2580
13. JT Carstensen F Attarchi 1988 J Pharm Sci 77 318 321
14. AM Abdoh M Al-Omari AA Badwan AMY Jaber 2004 Pharmaceut Dev Tech 9 15 24
15. RO Macêdo T Gomes do Nascimento JWE Veras 2002 J Therm Anal Cal 67 483 489
16. MJ Lovdahl TR Hurley B Tobias SR Priebe 2002 J Pharma and Biomed Anal 28 917 924
17. PA Harmon W Yin WE Bowen RJ Tyrrell RA Reed 1988 J Pharm Sci 89 920 929
18. A Flemming KM Picker-Freyer 2007 Eur J Pharm Biopharm 68 802 810
19. R Cavatur NM Vemuri Z Chrzan 2004 J Therm Anal Cal 78 63 72
20. AL Huidobro P Pruim P Schoenmakers C Barbas 2008 J Chromtogr A 1990 182 190
21. B Kramhöller M Pischertsrieder T Severin 1993 J Agric Food Chem 41 347 351
22. J Beck F Ledl T Severin 1988 Carbohydr Res 177 240 243