The expression and prognostic significance of Cks1 in salivary cancer

Cancer Investigation

Volumn 27, Issue 5, 2009, Pages 512-520

  Nagler, Rafael M ^a   Ben Izhak, Ofer ^a   Ostrovsky, Dimitri ^a   Golz, Avishai ^a   Hershko, Dan D ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Cancer; Cks1; Prognosis; Salivary glands; Ubiquitin

Indexed keywords

CYCLIN DEPENDENT KINASE 1; KI 67 ANTIGEN; PROTEIN P27; PROTEIN P53; S PHASE KINASE ASSOCIATED PROTEIN 2; CARRIER PROTEIN; CKS1B PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; CYCLINE; P27 ANTIGEN; S PHASE KINASE ASSOCIATED PROTEIN; TUMOR MARKER;

ACINAR CELL CARCINOMA; ADENOCARCINOMA; ADENOID CYSTIC CARCINOMA; ADOLESCENT; ADULT; AGED; ANAPLASTIC CARCINOMA; ARTICLE; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; NEUROENDOCRINE TUMOR; NICK END LABELING; ONCOCYTOMA; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SALIVARY GLAND CARCINOMA; SQUAMOUS CELL CARCINOMA; UNDIFFERENTIATED CARCINOMA; ADENOSQUAMOUS CARCINOMA; ENZYME IMMUNOASSAY; ENZYMOLOGY; GENETICS; METABOLISM; METASTASIS; MIDDLE AGED; PATHOLOGY; SALIVARY GLAND TUMOR; SURVIVAL RATE;

ADENOCARCINOMA; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, ACINAR CELL; CARCINOMA, MUCOEPIDERMOID; CARCINOMA, SQUAMOUS CELL; CARRIER PROTEINS; CYCLIN-DEPENDENT KINASES; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU NICK-END LABELING; KI-67 ANTIGEN; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; PROGNOSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; S-PHASE KINASE-ASSOCIATED PROTEINS; SALIVARY GLAND NEOPLASMS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53; YOUNG ADULT;

EID: 67449103462     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.1080/07357900802239116     Document Type: Article

References (22)

1. Hao, B.; Zheng, N.; Schulman, B.A.; Wu, G.; Miller, J.I.; Pagano, M.; Pavletich, N.P. Structural basis of the Cks1-dependent recognition of p27(Kip1) by the Scf(Skp2) ubiquitin ligase. Mol Cell 2005, 20, 9-19.
2. Ouellet, V.; Provencher, D.M.; Maugard, C.M.; Le Page, C.; Ren, F.; Lussier, C.; Novak, J.; Ge, B.; Hudson, T.I.; Tonin, P.N.; Mes-Masson, A.M. Discrimination between serous low malignant potential and invasive epithelial ovarian tumors using molecular profiling. Oncogene 2005, 24, 4672-4687.
3. Xu, S.; Abbasian, M.; Patel, P.; Jensen-Pergakes, K.; Lombardo, C.; Cathers, B.; Xie, W.; Mercurio, F.; Pagano, M.; Giegel, D.; Cox, S. Substrate recognition and ubiquitination of Scf Skp2/Cks1 ubiquitin-protein isopeptide Ligase. J Biol Chem 2007, 282, 15462-15470. (Pubitemid 47093271)
4. Westbrook, L.; Manuvakhova, M.; Kern, F.G.; Estes, N.R. 2nd; Ramanathan, H.N.; Thottassery, J.Y. Cks1 regulates Cdk1 expression: a novel role during mitotic entry in breast cancer cells. Cancer Res 2007, 67, 11393-11401.
5. Kawakami, K.; Enokida, H.; Tachiwada, T.; Nishiyama, K.; Seki, N.; Nakagawa, M. Increased Skp2 and Cks1 gene expression contributes to the progression of human urothelial carcinoma. J Urol 2007, 178, 301-307. (Pubitemid 46898455)
6. Hershko, D.D.; Shapira, M. The prognostic role of p27 deregulation in colorectal cancer. Cancer 2006, 107, 668-675. (Pubitemid 44232659)
7. Slotky, M.; Shapira, M.; Ben-Izhak, O.; Linn, S.; Futerman, B.; Tsalic, M.; Hershko, D.D. The expression of the ubiquitin ligase subunit Cks1 in human breast cancer. Breast Cancer Res 2005, 7, R737-R744.
8. Huang, H.Y.; Kang, H.Y.; Li, C.F.; Eng, H.L.; Chou, S.C.; Lin, C.N.; Hsiung, C.Y. Skp2 overexpression is highly representative of intrinsic biological aggressiveness and independently associated with poor prognosis in primary localized myxofibrosarcomas. Clin Cancer Res 2006, 12, 487-498.
9. Shapira, M.; Ben-Izhak, O.; Linn, S.; Futerman, B.; Minkov, I.; Hershko, D.D. The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma. Cancer 2005, 103, 1336-1346.
10. Spiro, R.H.; Dubner, S. Salivary gland tumors. Curr Opin Oncol 1990, 2, 589-595.
11. Eneroth, C.M. Salivary gland tumors in the parotid gland, submandibular gland, and the palate region. Cancer 1971, 27, 1415-1418.
12. Eveson, J.W.; Cawson, R.A. Salivary gland tumors. A review of 2410 cases with particular reference to histological types, site, age, and sex distribution. J Pathol 1985, 146, 51-58.
13. Nagler, R.M.; Barak, M.; Ben-Aryeh, H.; Peled, M.; Filatov, M.; Laufer, D. Early diagnostic and treatment monitoring role of Cyfra 21-1 and TPS in oral squamous cell carcinoma. Cancer 1999, 35, 1018-1025. (Pubitemid 29115578)
14. Ben-Izhak, O.; Laster, Z.; Araidy, S.; Nagler, R.M. TUNEL - an efficient predictor of salivary malignancies. Br J Cancer 2007, 96, 1101-1106.
15. Ben Izhak, O.; Kaplan-Cohen, V.; Ilan, N.; Gan, S.; Vlodavsky, I.; Nagler, R. Heparanase expression in malignant salivary gland tumors inversely correlates with long-term survival. Neoplasia 2006, 8, 879-884. (Pubitemid 44564843)
16. Seifert, G.; Sobin, L.H. The World Health Organization's Histological Classification of Salivary Gland Tumors. A commentary on the second edition. Cancer 1992, 70, 379-385.
17. Nagler, R.; Kerner, H.; Laufer, D.; Ben-Eliezer, S.; Minkov, I.; Ben-Yizhak, O. Squamous cell carcinoma of the tongue: the prevalence and prognostic roles of p53, Bcl-2, c-erbB-2, and apoptotic rate as related to clinical and pathological characteristics in a retrospective study. Cancer Lett 2002, 2, 137-150.
18. Nakayama, K.I.; Hatakeyama, S.; Nakayama, K. Regulation of the cell cycle at the G1-S transition by proteolysis of cyclin E and p27 Kip1. Biochem Biophys Res Commun 2001, 282, 853-860. (Pubitemid 32924572)
19. Ben-Izhak, O.; Kablan, F.; Laster, Z.; Nagler, R.M. Oropharyngeal cancer pathogenesis: ubiquitin proteolytic, apoptotic and epidermal growth factor related pathways act in concert - first report. Oral Oncol 2005, 41, 851-860.
20. Kudo, Y.; Kitajima, S.; Ogawa, I.; Miyauchi, M.; Takata, T. Downregulation of Cdk inhibitor p27 in oral squamous cell carcinoma. Oral Oncol 2005, 41, 105-116. (Pubitemid 40202876)
21. Bloom, J.; Pagano, M. Deregulated degradation of the cdk inhibitor p27 and malignant transformation. Semin Cancer Biol. 2003, 13, 41-47. (Pubitemid 36269179)
22. Strianese, D.; Baldi, G.; Staibano, S.; Baldi, A.; De Rosa, G.; Tranfa, F.; Bonavolonta, G. Expression of apoptosis-related markers in malignant epithelial tumors of the lacrimal gland and their relation to clinical outcome. Br J Ophthalmol 2007, 91, 1239-1243. (Pubitemid 47344907)