-
1
-
-
34547661985
-
L-BLP25: A peptide vaccine strategy in non small cell lung cancer
-
Sangha R, Butts C. L-BLP25: a peptide vaccine strategy in non small cell lung cancer. Clin Cancer Res 2007; 13:s4652-4.
-
(2007)
Clin Cancer Res
, vol.13
-
-
Sangha, R.1
Butts, C.2
-
2
-
-
27244449289
-
Randomized phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small-cell lung cancer
-
DOI 10.1200/JCO.2005.13.011
-
Butts C, Murray N, Maksymiuk A, et al. Randomized phase IIB trial of BLP25 liposome vaccine in stage IIIB and IV non-small-cell lung cancer. J Clin Oncol 2005; 23:6674-81. (Pubitemid 46190262)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.27
, pp. 6674-6681
-
-
Butts, C.1
Murray, N.2
Maksymiuk, A.3
Goss, G.4
Marshall, E.5
Soulieres, D.6
Cormier, Y.7
Ellis, P.8
Price, A.9
Sawhney, R.10
Davis, M.11
Mansi, J.12
Smith, C.13
Vergidis, D.14
Ellis, P.15
MacNeil, M.16
Palmer, M.17
-
4
-
-
34748815649
-
GSK's antigen-specific cancer immunotherapy programme: Pilot results leading to Phase III clinical development
-
DOI 10.1016/j.vaccine.2007.06.038, PII S0264410X07007049
-
Brichard VG, Lejeune D. GSK's antigen-specific cancer immunotherapy programme: pilot results leading to Phase III clinical development. Vaccine 2007; 25(suppl 2):B61-71. (Pubitemid 47488551)
-
(2007)
Vaccine
, vol.25
, Issue.SUPPL. 2
-
-
Brichard, V.G.1
Lejeune, D.2
-
5
-
-
42549106307
-
Final results of a multi-center, double-blind, randomized, placebo-controlled phase II study to assess the efficacy of MAGE-A3 immunotherapeutic as adjuvant therapy in stage IB/II non-small cell lung cancer (NSCLC)
-
(Abstract 7554)
-
Vansteenkiste J, Zielinski M, Linder A, et al. Final results of a multi-center, double-blind, randomized, placebo-controlled phase II study to assess the efficacy of MAGE-A3 immunotherapeutic as adjuvant therapy in stage IB/II non-small cell lung cancer (NSCLC). J Clin Oncol 2007; 25(18 suppl):398s (Abstract 7554).
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 SUPPL.
-
-
Vansteenkiste, J.1
Zielinski, M.2
Linder, A.3
-
7
-
-
0031775979
-
A novel cancer vaccine composed of human-recombinant epidermal growth factor linked to a carrier protein: Report of a pilot clinical trial
-
DOI 10.1023/A:1008261031034
-
Gonzalez G, Crombet T, Catala M, et al. A novel cancer vaccine composed of humanrecombinant epidermal growth factor linked to a carrier protein: report of a pilot clinical trial. Ann Oncol 1998; 9:431-5. (Pubitemid 28273037)
-
(1998)
Annals of Oncology
, vol.9
, Issue.4
, pp. 431-435
-
-
Gonzalez, G.1
Crombet, T.2
Catala, M.3
Mirabal, V.4
Hernandez, J.C.5
Gonzalez, Y.6
Marinello, P.7
Guillen, G.8
Lage, A.9
-
8
-
-
41149159650
-
Phase II randomized controlled trial of an epidermal growth factor vaccine in advanced non-small-cell lung cancer
-
Vinageras EN, de la Torre A, Rodriguez MO, et al. Phase II randomized controlled trial of an epidermal growth factor vaccine in advanced non-small-cell lung cancer. J Clin Oncol 2008; 26:1452-8.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1452-1458
-
-
Vinageras, E.N.1
De La Torre, A.2
Rodriguez, M.O.3
-
9
-
-
33750586798
-
Phase II study of belagenpumatucel-L, a transforming growth factor beta-2 antisense gene-modified allogeneic tumor cell vaccine in non-small-cell lung cancer
-
DOI 10.1200/JCO.2005.05.5335
-
Nemunaitis J, Dillman RO, Schwarzenberger PO, et al. Phase II study of belagenpumatucel- L, a transforming growth factor beta-2 antisense gene-modified allogeneic tumor cell vaccine in non-small-cell lung cancer. J Clin Oncol 2006; 24:4721-30. (Pubitemid 46630936)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.29
, pp. 4721-4730
-
-
Nemunaitis, J.1
Dillman, R.O.2
Schwarzenberger, P.O.3
Senzer, N.4
Cunningham, C.5
Cutler, J.6
Tong, A.7
Kumar, P.8
Pappen, B.9
Hamilton, C.10
DeVol, E.11
Maples, P.B.12
Liu, L.13
Chamberlin, T.14
Shawler, D.L.15
Fakhrai, H.16
-
10
-
-
84855303431
-
-
Available at Accessed: January 14, 2009
-
Clinicaltrials.gov [Web site]. Available at: http://www.clinicaltrials. gov/ct2/show/NCT00676507?term=Belagenpumatucel-L&rank=1. Accessed: January 14, 2009.
-
Clinicaltrials.gov [Web Site]
-
-
-
11
-
-
45549085804
-
Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses
-
de la Rosa G, Yang D, Tewary P, et al. Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses. J Immunol 2008; 180:6868-76.
-
(2008)
J Immunol
, vol.180
, pp. 6868-6876
-
-
De La Rosa, G.1
Yang, D.2
Tewary, P.3
-
12
-
-
48749104758
-
Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells
-
Spadaro M, Caorsi C, Ceruti P, et al. Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells. FASEB J 2008; 22:2747-57.
-
(2008)
FASEB J
, vol.22
, pp. 2747-2757
-
-
Spadaro, M.1
Caorsi, C.2
Ceruti, P.3
-
13
-
-
33646572848
-
Phase I trial of oral talactoferrin alfa in refractory solid tumors
-
DOI 10.1007/s10637-005-3690-6
-
Hayes TG, Falchook GF, Varadhachary GR, et al. Phase I trial of oral talactoferrin alfa in refractory solid tumors. Invest New Drugs 2006; 24:233-40. (Pubitemid 43723899)
-
(2006)
Investigational New Drugs
, vol.24
, Issue.3
, pp. 233-240
-
-
Hayes, T.G.1
Falchook, G.F.2
Varadhachary, G.R.3
Smith, D.P.4
Davis, L.D.5
Dhingra, H.M.6
Hayes, B.P.7
Varadhachary, A.8
-
14
-
-
56749176994
-
Adding oral talactoferrin to first-line NSCLC chemotherapy safely enhanced efficacy in a randomized trial
-
(Abstract 7095)
-
Wang Y, Raghunadharao D, Raman G, et al. Adding oral talactoferrin to first-line NSCLC chemotherapy safely enhanced efficacy in a randomized trial. J Clin Oncol 2006; 24(18 suppl):387s (Abstract 7095).
-
(2006)
J Clin Oncol
, vol.24
, Issue.18 SUPPL.
-
-
Wang, Y.1
Raghunadharao, D.2
Raman, G.3
-
15
-
-
77954372827
-
Oral talactoferrin extends survival in patients with refractory NSCLC in a randomized, placebo-controlled, phase 2 trial
-
(Abstract 7540)
-
Parikh PK, Wang Y, Ranade AA, et al. Oral talactoferrin extends survival in patients with refractory NSCLC in a randomized, placebo-controlled, phase 2 trial. J Clin Oncol 2007; 25(18 suppl):394s (Abstract 7540).
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 SUPPL.
-
-
Parikh, P.K.1
Wang, Y.2
Ranade, A.A.3
-
19
-
-
33751173659
-
The IGF-1 network in lung carcinoma therapeutics
-
DOI 10.1016/j.molmed.2006.10.003, PII S1471491406002243
-
Karamouzis MV, Papavassiliou AG. The IGF-1 network in lung carcinoma therapeutics. Trends Mol Med 2006; 12:595-602. (Pubitemid 44780198)
-
(2006)
Trends in Molecular Medicine
, vol.12
, Issue.12
, pp. 595-602
-
-
Karamouzis, M.V.1
Papavassiliou, A.G.2
-
20
-
-
0036847606
-
Serum insulin-like growth factor (IGF) and IGF-binding protein levels and risk of lung cancer: A case-control study nested in the β-carotene and retinol efficacy trial cohort
-
Spitz MR, Barnett MJ, Goodman GE, et al. Serum insulin-like growth factor (IGF) and IGF-binding protein levels and risk of lung cancer: a case-control study nested in the beta-Carotene and Retinol Efficacy Trial Cohort. Cancer Epidemiol Biomarkers Prev 2002; 11:1413-8. (Pubitemid 35340378)
-
(2002)
Cancer Epidemiology Biomarkers and Prevention
, vol.11
, Issue.11
, pp. 1413-1418
-
-
Spitz, M.R.1
Barnett, M.J.2
Goodman, G.E.3
Thornquist, M.D.4
Wu, X.5
Pollak, M.6
-
21
-
-
0037094239
-
Insulin-like growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in China
-
London SJ, Yuan JM, Travlos GS, et al. Insulin-like growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in China. J Natl Cancer Inst 2002; 94:749-54. (Pubitemid 34567959)
-
(2002)
Journal of the National Cancer Institute
, vol.94
, Issue.10
, pp. 749-754
-
-
London, S.J.1
Yuan, J.-M.2
Travlos, G.S.3
Gao, Y.-T.4
Wilson, R.E.5
Ross, R.K.6
Yu, M.C.7
-
22
-
-
0033113448
-
Insulin-like growth factors and cancer
-
Yu H, Berkel H. Insulin-like growth factors and cancer. J La State Med Soc 1999; 151:218-23.
-
(1999)
J la State Med Soc
, vol.151
, pp. 218-223
-
-
Yu, H.1
Berkel, H.2
-
23
-
-
36148953021
-
Phase i dose escalation study of the anti-IGF- 1R monoclonal antibody CP-751,871 in patients with refractory solid tumors
-
(Abstract 3586)
-
Haluska P, Shaw H, Batzel GN, et al. Phase I dose escalation study of the anti-IGF- 1R monoclonal antibody CP-751,871 in patients with refractory solid tumors. J Clin Oncol 2007; 25(18 suppl):444s (Abstract 3586).
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 SUPPL.
-
-
Haluska, P.1
Shaw, H.2
Batzel, G.N.3
-
24
-
-
54349107362
-
High activity of the anti-IGF-IR antibody CP-751,871 in combination with paclitaxel and carboplatin in squamous NSCLC
-
(Abstract 8015)
-
Karp DD, Paz-Ares LG, Novello S, et al. High activity of the anti-IGF-IR antibody CP-751,871 in combination with paclitaxel and carboplatin in squamous NSCLC. J Clin Oncol 2008; 26(15 suppl):427s (Abstract 8015).
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 SUPPL.
-
-
Karp, D.D.1
Paz-Ares, L.G.2
Novello, S.3
-
25
-
-
36048982143
-
Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non-small-cell lung cancer
-
DOI 10.1200/JCO.2007.12.3026
-
Herbst RS, O'Neill VJ, Fehrenbacher L, et al. Phase II study of efficacy and safety of bevacizumab in combination with chemotherapy or erlotinib compared with chemotherapy alone for treatment of recurrent or refractory non small-cell lung cancer. J Clin Oncol 2007; 25:4743-50. (Pubitemid 350086476)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.30
, pp. 4743-4750
-
-
Herbst, R.S.1
O'Neill, V.J.2
Fehrenbacher, L.3
Belani, C.P.4
Bonomi, P.D.5
Hart, L.6
Melnyk, O.7
Ramies, D.8
Lin, M.9
Sandler, A.10
-
26
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
DOI 10.1056/NEJMoa061884
-
Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006; 355:2542-50. (Pubitemid 44917502)
-
(2006)
New England Journal of Medicine
, vol.355
, Issue.24
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
Brahmer, J.4
Schiller, J.H.5
Dowlati, A.6
Lilenbaum, R.7
Johnson, D.H.8
-
27
-
-
49249123830
-
Maintenance pemetrexed plus best supportive care (BSC) versus placebo plus BSC: A phase III study
-
(Abstract 8011)
-
Ciuleanu TE, Brodowicz T, Belani CP, et al. Maintenance pemetrexed plus best supportive care (BSC) versus placebo plus BSC: a phase III study. J Clin Oncol 2008 26:(15 suppl)426s (Abstract 8011).
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 SUPPL.
-
-
Ciuleanu, T.E.1
Brodowicz, T.2
Belani, C.P.3
-
28
-
-
49049089802
-
Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
-
Scagliotti GV, Parikh P, von Pawel J, et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008; 26:3543-51.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3543-3551
-
-
Scagliotti, G.V.1
Parikh, P.2
Von Pawel, J.3
-
29
-
-
33745928129
-
Smoking history and epidermal growth factor receptor expression as predictors of survival benefit from erlotinib for patients with non-small-cell lung cancer in the National Cancer Institute of Canada Clinical Trials Group Study br.21
-
Clark GM, Zborowski DM, Santabarbara P, et al. Smoking history and epidermal growth factor receptor expression as predictors of survival benefit from erlotinib for patients with non-small-cell lung cancer in the National Cancer Institute of Canada Clinical Trials Group study BR.21. Clin Lung Cancer 2006; 7:389-94. (Pubitemid 44043548)
-
(2006)
Clinical Lung Cancer
, vol.7
, Issue.6
, pp. 389-394
-
-
Clark, G.M.1
Zborowski, D.M.2
Santabarbara, P.3
Ding, K.4
Whitehead, M.5
Seymour, L.6
Shepherd, F.A.7
-
30
-
-
22044453790
-
Erlotinib in lung cancer - Molecular and clinical predictors of outcome
-
DOI 10.1056/NEJMoa050736
-
Tsao MS, Sakurada A, Cutz JC, et al. Erlotinib in lung cancer - molecular and clinical predictors of outcome. N Engl J Med 2005; 353:133-44. (Pubitemid 41058345)
-
(2005)
New England Journal of Medicine
, vol.353
, Issue.2
, pp. 133-144
-
-
Tsao, M.-S.1
Sakurada, A.2
Cutz, J.-C.3
Zhu, C.-Q.4
Kamel-Reid, S.5
Squire, J.6
Lorimer, I.7
Zhang, T.8
Liu, N.9
Daneshmand, M.10
Marrano, P.11
Da Cunha Santos, G.12
Lagarde, A.13
Richardson, F.14
Seymour, L.15
Whitehead, M.16
Ding, K.17
Pater, J.18
Shepherd, F.A.19
-
33
-
-
72449143306
-
-
Clinicaltrials.gov [Web site] Accessed: January 14, 2009
-
Clinicaltrials.gov [Web site]. Trial of CP-751, 871 and erlotinib in refractory lung cancer (NSCLC). Available at: http://www.clinicaltrials.gov/ct2/ show/NCT00673049?term=CP-751%2C871&rank=2. Accessed: January 14, 2009.
-
Trial of CP-751, 871 and Erlotinib in Refractory Lung Cancer (NSCLC)
-
-
-
34
-
-
33846889291
-
Growth factor receptor interplay and resistance in cancer
-
DOI 10.1677/erc.1.01275
-
Jones HE, Gee JM, Hutcheson IR, et al. Growth factor receptor interplay and resistance in cancer. Endocr Relat Cancer 2006; 13(suppl 1):S45-51. (Pubitemid 46219248)
-
(2006)
Endocrine-Related Cancer
, vol.13
, Issue.SUPPL. 1
-
-
Jones, H.E.1
Gee, J.M.W.2
Hutcheson, I.R.3
Knowlden, J.M.4
Barrow, D.5
Nicholson, R.I.6
-
35
-
-
0028362024
-
A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor
-
Coppola D, Ferber A, Miura M, et al. A functional insulin-like growth factor I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor. Mol Cell Biol 1994; 14:4588-95. (Pubitemid 24196808)
-
(1994)
Molecular and Cellular Biology
, vol.14
, Issue.7
, pp. 4588-4595
-
-
Coppola, D.1
Ferber, A.2
Miura, M.3
Sell, C.4
D'Ambrosio, C.5
Rubin, R.6
Baserga, R.7
-
36
-
-
25844467799
-
Insulin-like growth factor-1 receptor signaling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells
-
Jones HE, Goddard L, Gee JM, et al. Insulin-like growth factor-1 receptor signaling and acquired resistance to gefitinib (ZD1839; Iressa) in human breast and prostate cancer cells. Endocr Relat Cancer 2004; 11:1-22.
-
(2004)
Endocr Relat Cancer
, vol.11
, pp. 1-22
-
-
Jones, H.E.1
Goddard, L.2
Gee, J.M.3
-
37
-
-
33846889291
-
Growth factor receptor interplay and resistance in cancer
-
DOI 10.1677/erc.1.01275
-
Jones HE, Gee JM, Hutcheson IR, et al. Growth factor receptor interplay and resistance in cancer. Endocr Relat Cancer 2006; 13(suppl 1):S45-51. (Pubitemid 46219248)
-
(2006)
Endocrine-Related Cancer
, vol.13
, Issue.SUPPL. 1
-
-
Jones, H.E.1
Gee, J.M.W.2
Hutcheson, I.R.3
Knowlden, J.M.4
Barrow, D.5
Nicholson, R.I.6
-
38
-
-
0036141447
-
Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling
-
Chakravati A, Loeffler JS, Dyson NJ. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastome cells through continued activation of phosphoinositide 3-kinase signaling. Cancer Res 2002; 62:200-7. (Pubitemid 34074005)
-
(2002)
Cancer Research
, vol.62
, Issue.1
, pp. 200-207
-
-
Chakravarti, A.1
Loeffler, J.S.2
Dyson, N.J.3
-
39
-
-
0035810044
-
Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody
-
DOI 10.1038/sj.onc.1204277
-
Liu B, Fang M, Lu Y, et al. Fibroblast growth factor and insulin-like growth factor differentially modulate the apoptosis and G1 arrest induced by anti-epidermal growth factor receptor monoclonal antibody. Oncogene 2001; 20:1913-22. (Pubitemid 32458701)
-
(2001)
Oncogene
, vol.20
, Issue.15
, pp. 1913-1922
-
-
Liu, B.1
Fang, M.2
Lu, Y.3
Mendelsohn, J.4
Fan, Z.5
-
40
-
-
4143095430
-
Altered Hsp90 function in cancer: A unique therapeutic opportunity
-
Bagatell R, Whitesell L. Altered Hsp90 function in cancer: a unique therapeutic opportunity. Mol Cancer Ther 2004; 3:1021-30. (Pubitemid 39199597)
-
(2004)
Molecular Cancer Therapeutics
, vol.3
, Issue.8
, pp. 1021-1030
-
-
Bagatell, R.1
Whitesell, L.2
-
41
-
-
0028064940
-
Inhibition of heat shock protein HSP90- pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation
-
Whitesell L, Minnaugh EG, De Costa B et al. Inhibition of heat shock protein HSP90- pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. PNAS USA 1994; 91:8324-8.
-
(1994)
PNAS USA
, vol.91
, pp. 8324-8328
-
-
Whitesell, L.1
Minnaugh, E.G.2
De Costa, B.3
-
42
-
-
0141596326
-
Clinical development of 17-allylamino, 17-demethoxygeldanamycin
-
DOI 10.2174/1568009033481831
-
Sausville EA, Tomaszewski JE, Ivy P. Clinical development of 17-allylamino, 17-demethoxygeldanamycin. Curr Cancer Drug Targets 2003; 3:377-83. (Pubitemid 37128324)
-
(2003)
Current Cancer Drug Targets
, vol.3
, Issue.5
, pp. 377-383
-
-
Sausville, E.A.1
Tomaszewski, J.E.2
Ivy, P.3
-
44
-
-
22244485706
-
Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins
-
DOI 10.1158/0008-5472.CAN-05-0933
-
Shimamura T, Lowell AM, Engelman JA, et al. Epidermal growth factor receptors harboring kinase domain mutations associate with the heat shock protein 90 chaperone and are destabilized following exposure to geldanamycins. Cancer Res 2005; 65:6401-8. (Pubitemid 40994428)
-
(2005)
Cancer Research
, vol.65
, Issue.14
, pp. 6401-6408
-
-
Shimamura, T.1
Lowell, A.M.2
Engelman, J.A.3
Shapiro, G.I.4
-
45
-
-
44649083135
-
Hsp90 inhibition suppresses mutant EGFRT790M signaling and overcomes kinase inhibitor resistance
-
Shimamura T, Li D, Ji H, et al. Hsp90 inhibition suppresses mutant EGFRT790M signaling and overcomes kinase inhibitor resistance. Cancer Res 2008; 68:5827-38.
-
(2008)
Cancer Res
, vol.68
, pp. 5827-5838
-
-
Shimamura, T.1
Li, D.2
Ji, H.3
|