Aberrant DNA methylation in thymic epithelial tumors

Cancer Investigation

Volumn 27, Issue 5, 2009, Pages 582-591

  Chen, Chen ^a   Yin, Bangliang ^a,b   Wei, Qiyou ^a   Li, Daiqiang ^a   Hu, Jianguo ^a   Yu, Fenglei ^a   Lu, Qianjin ^a,b  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b NONE   (China)

Author keywords

DNA methylation; DNA methyltransferase; Methylation specific PCR; Thymic epithelial tumors; Tumor suppressor gene

Indexed keywords

DNA; DNA METHYLTRANSFERASE; MESSENGER RNA; TUMOR SUPPRESSOR PROTEIN;

ADOLESCENT; ADULT; ADVANCED CANCER; AGED; ARTICLE; DISEASE SEVERITY; DNA METHYLATION; EARLY CANCER; EPITHELIUM TUMOR; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; THYMIC EPITHELIAL TUMOR; THYMOMA; TUMOR SUPPRESSOR GENE; CANCER STAGING; CPG ISLAND; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; NEOPLASM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADOLESCENT; ADULT; AGED; CPG ISLANDS; DNA METHYLATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; NEOPLASMS, GLANDULAR AND EPITHELIAL; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYMUS NEOPLASMS; TUMOR SUPPRESSOR PROTEINS; YOUNG ADULT;

EID: 67449090048     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.1080/07357900802620869     Document Type: Article

References (36)

1. Masaoka, A.; Monden, Y.; Nakahara, K.; Tanioka, T. Follow-up study of thymomas with special reference to their clinical stages. Cancer 1981, 48, 2485-2492. (Pubitemid 12228012)
2. Shimosato, Y. Controversies surrounding the subclassification of thymoma. Cancer 1994, 74, 542-544.
3. Quintanilla-Martinez, L.; Wilkins, E.W., Jr.; Choi, N.; Efird, J.; Hug, E.; Harris, N.L. Thymoma. Histologic subclassification is an independent prognostic factor. Cancer 1994, 74, 606-617. (Pubitemid 24217624)
4. Lardinois, D.; Rechsteiner, R.; Lang, R.H.; Gugger, M.; Betticher, D.; von Briel, C.; Krueger, T.; Ris, H.B. Prognostic relevance of Masaoka and Muller-Hermelink classification in patients with thymic tumors. Ann Thorac Surg 2000, 69, 1550-1555.
5. Rosai, J.; Sobin, L.H. Histological typing of tumors of the thymus. International Histological Classification of Tumors, 2nd edition. New York, Berlin: Springer, 1999.
6. Nakagawa, K.; Asamura, H.; Matsuno, Y.; Suzuki, K.; Kondo, H.; Maeshima, A.; Miyaoka, E.; Tsuchiya, R. Thymoma: a clinicopathologic study based on the new World Health Organization classification. J Thorac Cardiovasc Surg 2003, 126, 1134-1140. (Pubitemid 37305702)
7. Chen, G.; Marx, A.; Wen-Hu, C.; Yong, J.; Puppe, B.; Stroebel, P.; Mueller-Hermelink, H.K. New WHO histological classification predicts prognosis of thymic epithelial tumors. A clinicopathologic study of 200 thymoma cases from China. Cancer 2002, 95, 420-429.
8. Ströbel, P.; Bauer, A.; Puppe, B.; Kraushaar, T.; Krein, A.; Toyka, K.; Gold, R.; Semik, M.; Kiefer, R.; Nix, W.; Schalke, B.; Müller- Hermelink, H.K.; Marx, A. Tumor recurrence and survival in patients treated for thymomas and thymic squamous cell carcinomas: a retrospective analysis. J Clin Oncol 2004, 22, 1501-1509. (Pubitemid 41103633)
9. Wentao, F.; Wenhu, C.; Gang, C.; Yong, J. Surgical management of thymic epithelial tumors: a retrospective review of 204 cases. Ann Thorac Surg 2005, 80, 2002-2007. (Pubitemid 41718017)
10. Zisis, C.; Rontogianni, D.; Tzavara, C.; Stefanaki, K.; Chatzimichalis, A.; Loutsidis, A.; Iliadis, K.; Kontaxis, A.; Dosios, T.; Bellenis, I. Prognostic factors in thymic epithelial tumors undergoing complete resection. Ann Thorac Surg 2005, 80, 1056-1062. (Pubitemid 41196815)
11. Rountree, M.R.; Bachman, K.E.; Herman, J.G.; Baylin, S.B. DNA methylation, chromatin inheritance, and cancer. Oncogene 2001, 20, 3156-3165. (Pubitemid 32553571)
12. Matsuzaki, K.; Deng, G.; Tanaka, H.; Kakar, S.; Miura, S.; Kim, Y.S. The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer. Clin Cancer Res 2005, 8564-8569. (Pubitemid 43005901)
13. Eden, A.; Gaudet, F.; Waghmare, A.; Jaenisch, R. Chromosomal instability and tumors promoted by DNA hypomethylation. Science 2003, 300, 455. (Pubitemid 36444319)
14. Ehrlich, M. DNA methylation in cancer: too much, but also too little. Oncogene 2002, 21, 5400-5413. (Pubitemid 34983477)
15. Tuck-Muller, C.M.; Narayan, A.; Tsien, F.; Smeets, D.F.; Sawyer, J.; Fiala, E.S.; Sohn, O.S.; Ehrlich, M. DNA hypomethylation and unusual chromosome instability in cell lines from ICF syndrome patients. Cytogenet Cell Genet 2000, 89, 121-128. (Pubitemid 30435274)
16. Deng, G.; Nguyen, A.; Tanaka, H.; Matsuzaki, K.; Bell, I.; Mehta, K.R.; Terdiman, J. P.; Waldman, F.M.; Kakar, S.; Gum, J.; Crawley, S.; Sleisenger, M.H.; Kim, Y.S. Regional hypermethylation and global hypomethylation are associated with altered chromatin conformation and histone acetylation in colorectal cancer. Int J Cancer 2006, 118, 2999-3005.
17. Kondo, Y.; Issa, J.P. Epigenetic changes in colorectal cancer. Cancer Metastasis Rev 2004, 23, 29-39.
18. Tomizawa, Y.; Iijima, H.; Nomoto, T.; Iwasaki, Y.; Otani, Y.; Tsuchiya, S.; Saito, R.; Dobashi, K.; Nakajima, T.; Mori, M. Clinicopathological significance of aberrant methylation of RARβ2 at 3p24, RASSF1A at 3p21.3, and FHIT at 3p14.2 in patients with non-small cell lung cancer. Lung Cancer 2004, 46(3), 305-312.
19. Kim, D.S.; Kim M.J.; Lee J.Y.; Kim, Y.Z.; Kim, E.J.; Park, J.Y. Aberrant methylation of E-cadherin and H-cadherin genes in nonsmall cell lung cancer and its relation to clinicopathologic features. Cancer 2007, 110(12), 2785-2792.
20. Fischer, J.R.; Ohnmacht, U.; Rieger, N.; Zemaitis, M.; Stoffregen, C.; Manegold, C.; Lahm, H. Prognostic significance of RASSF1A promoter methylation on survival of non-small cell lung cancer patients treated with gemcitabine. Lung Cancer 2007, 56(1), 115-123. (Pubitemid 46371331)
21. Corn, P.G.; Heath, E.I.; Heitmiller, R.; Fogt, F.; Forastiere, A.A.; Herman, J.G.; Wu, T.T. Frequent Hypermethylation of the 5-CpG Island of E-Cadherin in Esophageal Adenocarcinoma. Clin Cancer Res 2001, 7, 2765-2769. (Pubitemid 32911382)
22. van Engeland, M.; Weijenberg, M.P.; Roemen, G.M.; Brink, M.; de Bruine, A.P.; Goldbohm, R.A.; van den Brandt, P.A.; Baylin, S.B.; de Goeij, A.F.; Herman, J.G. Effects of dietary folate and alcohol intake on promoter methylation in sporadic colorectal cancer: the Netherlands cohort study on diet and cancer. Cancer Res 2003, 63(12), 3133-3137.
23. Girault, I.; Tozlu, S.; Lidereau, R.; Bieche, I. Expression analysis of DNA methyltransferases 1, 3A, and 3B in sporadic breast carcinomas. Clin Cancer Res 2003, 9(12), 4415-4422. (Pubitemid 37248399)
24. Shieh, Y.S.; Shiah, S.G.; Jeng, H.H.; Lee, H.S.; Wu, C.W.; Chang, L.C. DNA methyltransferase 1 expression and promoter methylation of E-cadherin in mucoepidermoid carcinoma. Cancer 2005, 104(5), 1013-1021. (Pubitemid 41170229)
25. Zettl, A.; Strobel, P.; Wagner, K.; Katzenberger, T.; Ott, G.; Rosenwald, A.; Peters, K.; Krein, A.; Semik, M.; Müller-Hermelink, H.K.; Marx, A. Recurrent genetic aberrations in thymoma and thymic carcinoma. Am J Pathol 2000, 157, 257-266. (Pubitemid 30642585)
26. Hirabayashi, H.; Fujii, Y.; Sakaguchi, M.; Tanaka, H.; Yoon, H.E.; Komoto, Y.; Inoue, M.; Miyoshi, S.; Matsuda, H. p16INK4a, pRB, p53 and cyclin D1 expression and hypermethylation of CDKN2 gene in thymoma and thymic carcinoma. Int J Cancer 1997, 73(5), 639-644.
27. Long, C.; Yin, B.; Lu, Q.; Zhou, X.; Hu, J.; Yang, Y.; Yu, F.; Yuan, Y. Promoter hypermethylation of the RUNX3 gene in esophageal squamous cell carcinoma. Cancer Invest 2007, 25(8), 685-690. (Pubitemid 350223164)
28. Hernandez-Blazquez, F.J.; Habib, M.; Dumollard, J.M.; Barthelemy, C.; Benchaib, M.; de Capoa, A.; Niveleau, A. Evaluation of global DNA hypomethylation in human colon cancer tissues by immunohistochemistry and image analysis. Gut 2000, 47(5), 689-693. (Pubitemid 30809048)
29. Esteller, M.; Herman, J.G. Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumors. J Pathol 2002, 196, 1-7. (Pubitemid 34071572)
30. Wilson, A.S.; Power, B.E.; Molloy, P.L. DNA hypomethylation and human diseases. Biochim Biophys Acta 2007, 1775(1), 138-162.
31. de Capoa, A.; Musolino, A.; Della Rosa, S.; Caiafa, P.; Mariani, L.; Del Nonno, F.; Vocaturo, A.; Donnorso, R.P.; Niveleau, A.; Grappelli, C. DNA demethylation is directly related to tumour progression: evidence in normal, pre-malignant and malignant cells from uterine cervix samples. Oncol Rep 2003, 10(3), 545-549.
32. Piyathilake, C.J.; Frost, A.R.; Bell, W.C.; Oelschlager, D.; Weiss, H.; Johanning, G.L.; Niveleau, A.; Heimburger, D.C.; Grizzle, W.E. Altered global methylation of DNA: an epigenetic difference in susceptibility for lung cancer is associated with its progression. Hum Pathol 2001, 32(8), 856-862.
33. Piyathilake, C.J.; Henao, O.; Frost, A.R.; Macaluso, M.; Bell, W.C.; Johanning, G.L.; Heimburger, D.C.; Niveleau, A.; Grizzle, W.E. Race- and age-dependent alterations in global methylation of DNA in squamous cell carcinoma of the lung (United States). Cancer Causes Control 2003, 14(1), 37-42.
34. Seifert, H.H.; Schmiemann, V.; Mueller, M.; Kazimirek, M.; Onofre, F.; Neuhausen, A.; Florl, A.R.; Ackermann, R.; Boecking, A.; Schulz, W.A.; Grote, H.J. In situ detection of global DNA hypomethylation in exfoliative urine cytology of patients with suspected bladder cancer. Exp Mol Pathol 2007, 82(3), 292-297.
35. Brothman, A.R.; Swanson, G.; Maxwell, T.M.; Cui, J.; Murphy, K.; Herrick, J.; Speights, V.; Isaac, J.; Rohr, L. Global hypomethylation is common in prostate cancer cells: a quantitative predictor for clinical outcome? Cancer Genet Cytogenet 2005, 156(1), 31-36.
36. Yang, X.; Phillips, D.L.; Ferguson, A.T.; Nelson, W.G.; Herman, J.G.; Davidson, N.E. Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ER-alpha-negative breast cancer cells. Cancer Res 2001, 61(19), 7025-7029.