Pro-inflammatory cytokine release by peripheral blood mononuclear cells from patients with advanced pancreatic cancer: Relationship to acute phase response and survival

Oncology Reports

Volumn 21, Issue 4, 2009, Pages 1091-1095

  Moses, Alastair G W ^a   Maingay, Jean ^a   Sangster, Kathryn ^a   Fearon, Kenneth C H ^a   Ross, James A ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

C reactive protein; Cachexia; Cytokines; Interleukin 6

Indexed keywords

ACUTE PHASE PROTEIN; ALBUMIN; C REACTIVE PROTEIN; CYTOKINE; INTERLEUKIN 1; INTERLEUKIN 6; ICOSAPENTAENOIC ACID;

ACUTE PHASE RESPONSE; ADVANCED CANCER; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; BODY MASS; CACHEXIA; CANCER MORTALITY; CANCER STAGING; CANCER SURVIVAL; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; FEMALE; HUMAN; KARNOFSKY PERFORMANCE STATUS; MALE; MONOCYTE; NUTRITIONAL STATUS; PANCREAS CANCER; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; VOLUNTEER; BLOOD; IMMUNOLOGY; MONONUCLEAR CELL; MORTALITY; PANCREAS TUMOR;

ACUTE-PHASE REACTION; AGED; C-REACTIVE PROTEIN; CYTOKINES; EICOSAPENTAENOIC ACID; FEMALE; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; LEUKOCYTES, MONONUCLEAR; MALE; PANCREATIC NEOPLASMS;

EID: 67449088926     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000328     Document Type: Article

References (22)

1. Falconer JS, Fearon KC, Plester CE, Ross JA and Carter DC: Cytokines, the acute-phase response, and resting energy expenditure in cachectic patients with pancreatic cancer. Ann Surg 219: 325-331, 1994.
2. Falconer JS, Fearon KCH, Ross JA, Elton R, Wigmore SJ, Garden OJ and Carter DC: Acute-phase protein response and survival duration of patients with pancreatic cancer. Cancer 75: 2077-2082, 1995.
3. Castell JV, Gomez-Lechon MJ, David M, Fabra R, Trullenque R and Heinrich PC: Acute-phase response of human hepatocytes: regulation of acute phase protein synthesis by interleukin-6. Hepatology 12: 1179-1186, 1990.
4. Beutler B and Cerami A: Cachectin and tumour necrosis factor as two sides of the same biologic coin. Nature 320: 584-588, 1986.
5. Plata-Salaman CR: Central nervous system mechanisms contributing to the cachexia-anorexia syndrome. Nutrition 16: 1009-1012, 2000.
6. King PJ, Widdowson PS, Doods H and Williams G: Effect of cytokines on hypothalamic neropeptide Y release in vitro. Peptides 21: 143-146, 2000.
7. Wigmore SJ, Plester CE, Richardson RA and Fearon KC: Changes in nutritional status associated with unresectable pancreatic cancer. Br J Cancer 75: 106-109, 1997.
8. Hannan WJ, Cowen SJ, Plester CE, Fearon KC and deBeau A: Comparison of bio-impedance spectroscopy and multifrequency bio-impedance analysis for the assessment of extracellular and total body water in surgical patients. Clin Sci 89: 651-658, 1995.
9. Wigmore SJ, Ross JA, Falconer JS, Plester CE, Tisdale MJ, Carter DC and Fearon KC: The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer. Nutrition 12: S27-S30, 1996.
10. Barber MD, Ross JA, Voss AC, Tisdale MJ and Fearon KC: The effect of an oral nutritional supplement enriched with fish oil on weight-loss in patients with pancreatic cancer. Br J Cancer 81: 80-86, 1999.
11. Endres S, Ghorbani R, Kelley VE, Georgilis K, Lonnemann G, Van der Meer JW, Cannon JG, Rogers TS, Klempner MS and Weber PC: The effect of dietry supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumour necrosis factor by mononuclear cells. N Engl J Med 320: 265-271, 1989.
12. Meydani SN, Lichenstein AH, Cornwall S, Meydani M, Goldin BR, Rasmussen H, Dinarello CA and Schaefer EJ: Immunological effects of National Cholesterol Education Panel Step-2 diets with and without fish-derived n-3 fatty acid enrichment. J Clin Invest 92: 105-113, 1993.
13. Wigmore SJ, Fearon KCH, Maingay JP and Ross JA: Down regulation of the acute-phase response in patients with pancreatic cancer cachexia receiving oral eicosapentaenoic acid is mediated via suppression of interleukin-6. Clin Sci 92: 215-221, 1997.
14. Staal-van den Brekel AJ, Dentener MA, Schols AMWJ, Buurman WA and Wouters EF: Increased resting energy expenditure and weight loss are related to a systemic inflammatory response in lung cancer patients. J Clin Oncol 13: 2600-2605, 1995.
15. Wayman J, O'Hanlon D, Hayes N, Shaw I and Griffin SM: Fibrinogen levels correlate with stage of disease in patients with oesophageal cancer. Br J Surg 84: 185-188, 1997.
16. Moldawer LL, Andersson C, Gelin J and Lundholm KG: Regulation of food intake and hepatic protein synthesis by recombinant derived cytokines. Am J Physiol 254: G450-G456, 1988.
17. Hellerstein MK, Meydani SN, Meydani M, Wu K and Dinarello CA: Interleukin-1 induced anorexia in the rat. Influence of prostaglandins. J Clin Invest 84: 228-235, 1989.
18. Okada S, Okusaka T, Ishii H, Kyogoku A, Yoshimori M, Kajimura N, Yamaguchi K and Kakizoe T: Elevated serum interleukin-6 levels in patients with pancreatic cancer. Jpn J Clin Oncol 28: 12-15, 1998.
19. Martin F, Santolaria F, Batista N, Milena A, Gonzalez-Reimers E, Brito MJ and Oramas J: Cytokine levels (IL-6 and IFN-gamma), acute phase response and nutritional status as prognostic factors in lung cancer. Cytokine 11: 80-86, 1999.
20. Barber MD, Ross JA and Fearon KC: Changes in nutritional, functional, and inflammatory markers in advanced pancreatic cancer. Nutr Cancer 35: 106-110, 1999.
21. Fearon KCH, Falconer JS, Slater C, McMillan DC, Ross JA and Preston T: Albumin synthesis rates are not decreased in hypoalbuminemic cachectic cancer patients with an ongoing acutephase protein response. Ann Surg 227: 249-254, 1998.
22. Martignoni ME, Kunze P, Hildebrandt W, Kunzli B, Berberat P, Giese T, Kloters O, Hammer J, Buchler MW, Giese NA and Friess H: Role of mononuclear cells and inflammatory cytokines in pancreatic cancer-related cachexia. Clin Cancer Res 11: 5802-5808, 2005.