Dietary sources of nitrite as a modulator of ischemiareperfusion injury

Kidney International

Volumn 75, Issue 11, 2009, Pages 1140-1144

  Garg, Harsha K ^a   Bryan, Nathan S ^a  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Cardiovascular disease; Diet; Nitrate; Nitric oxide; Nutrition

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE;

CELL PROTECTION; DIET; ISCHEMIA; NITROGEN CYCLE; PRIORITY JOURNAL; REPERFUSION INJURY; SHORT SURVEY;

EID: 67349287799     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2009.13     Document Type: Short Survey

References (20)

1. Kleinbongard P, Dejam A, Lauer T et al. Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans. Free Radic Biol Med 2006; 40: 295-302.
2. Bryan NS, Fernandez BO, Bauer SM et al. Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues. Nat Chem Biol 2005; 1: 290-297.
3. Kelm M. Nitric oxide metabolism and breakdown. Biochim Biophys Acta 1999; 1411: 273-289.
4. Rhodes P, Leone AM, Francis PL et al. The L-arginine:nitric oxide pathway is the major source of plasma nitrite in fasted humans. Biochem Biophys Res Commun 1995; 209: 590-596.
5. Benjamin N, O'Driscoll F, Dougall H et al. Stomach NO synthesis. Nature 1994; 368: 502.
6. Lundberg JO, Weitzberg E, Lundberg JM et al. Intragastric nitric oxide production in humans: measurements in expelled air. Gut 1994; 35: 1543-1546.
7. Spiegelhalder B, Eisenbrand G, Preussmann R. Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds. Food Cosmet Toxicol 1976; 14: 545-548.
8. Björne HH, Petersson J, Phillipson M et al. Nitrite in saliva increases gastric mucosal blood flow and mucus thickness. J Clin Invest 2004; 113: 106-114.
9. Jansson EA, Huang L, Malkey R et al. A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis. Nat Chem Biol 2008; 4: 411-417.
10. Garg H. Diet and Cardiovascular Disease: The Role of Antioxidants and Nitrite. Boston University: Boston, 2006, pp 1-54.
11. Tsuchiya K, Kanematsu Y, Yoshizumi M et al. Nitrite is an alternative source of NO in vivo. Am J Physiol Heart Circ Physiol 2005; 288: H2163-H2170.
12. Kanematsu Y, Yamaguchi K, Ohnishi H et al. Dietary doses of nitrite restore circulating nitric oxide level and improve renal injury in L-NAME-induced hypertensive rats. Am J Physiol Renal Physiol 2008; 295: F1457-F1462.
13. Tripatara P, Patel NS, Webb A et al. Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase. J Am Soc Nephrol 2007; 18: 570-580.
14. Basireddy M, Isbell TS, Teng X et al. Effects of sodium nitrite on ischemia-reperfusion injury in the rat kidney. Am J Physiol Renal Physiol 2006; 290: F779-F786.
15. Lundberg JO, Govoni M. Inorganic nitrate is a possible source for systemic generation of nitric oxide. Free Radic Biol Med 2004; 37: 395-400.
16. Bryan NS, Calvert JW, Gundewar S et al. Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthase-deficient mice. Free Radic Biol Med 2008; 45: 468-474.
17. Bryan NS, Calvert JW, Elrod JW et al. Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury. Proc Natl Acad Sci USA 2007; 104: 19144-19149.
18. Webb AJ, Patel N, Loukogeorgakis S et al. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension 2008; 51: 784-790.
19. Larsen FJ, Ekblom B, Sahlin K et al. Effects of dietary nitrate on blood pressure in healthy volunteers. N Engl J Med 2006; 355: 2792-2793.
20. Shiva S, Sack MN, Greer JJ et al. Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer. J Exp Med 2007; 204: 2089-2102.