Granzymes A and B serum levels in allo-SCT

Bone Marrow Transplantation

Volumn 43, Issue 10, 2009, Pages 787-791

  Kircher, B ^a   Schumacher, P ^a   Nachbaur, D ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CYCLOSPORIN A; GRANZYME A; GRANZYME B; METHOTREXATE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; THYMOCYTE ANTIBODY;

ACUTE GRAFT VERSUS HOST DISEASE; ACUTE LEUKEMIA; ADULT; AGED; ALLOGENEIC STEM CELL TRANSPLANTATION; ARTICLE; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DISEASE SEVERITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GRAFT VERSUS HOST REACTION; HUMAN; IN VIVO STUDY; INCIDENCE; LEUKEMIA RELAPSE; LOW DRUG DOSE; LYMPHOMA; MAJOR CLINICAL STUDY; MYELOABLATIVE CONDITIONING; MYELODYSPLASTIC SYNDROME; MYELOMA; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; REDUCED INTENSITY CONDITIONING; RISK ASSESSMENT; SURVIVAL TIME;

ADOLESCENT; ADULT; AGED; BIOLOGICAL MARKERS; CYTOMEGALOVIRUS INFECTIONS; GRAFT VS HOST DISEASE; GRANZYMES; HEMATOLOGIC NEOPLASMS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; INCIDENCE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; TIME FACTORS; TRANSPLANTATION, AUTOLOGOUS; YOUNG ADULT;

EID: 67349284719     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/bmt.2008.395     Document Type: Article

References (31)

1. Pipkin ME, Lieberman J. Delivering the kiss of death: Progress on understanding how perforin works. Curr Opin Immunol 2007; 19 301-308.
2. Braun MY, Lowin B, French L, Acha-Orbea H, Tschopp J. Cytotoxic T cells deficient in both functional Fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal graft-versus-host disease. Blood 1996; 183: 657-661.
3. Baker MB, Altman NH, Podack ER, Levy RB. The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice. J Exp Med 1996; 183: 2645-2656.
4. Schmaltz C, Alpdogan O, Horndasch KJ, Muriglan SJ, Kappel BJ, Teshima T et al. Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graftversus-host disease and graft-versus-leukemia effect. Blood 2001; 97: 2886-2895.
5. Graubert TA, Russell JH, Ley TJ. The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection. Blood 1996; 87: 1232-1237.
6. Graubert TA, DiPersio JF, Russell JH, Ley TJ. Perforin/ granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation. J Clin Invest 1997; 100: 904-911.
7. Takata M. Immunohistochemical identification of perforin-positive cytotoxic lymphocytes in graft-versus-host disease. Am J Clin Pathol 1995; 103: 324-329.
8. Higaki Y, Yamada O, Okamura T, Mizoguchi H, Kawashima M. Granzyme-B-containing lymphocyte involvement in epidermal injury in graft-versus-host disease. Dermatology 2001; 202: 94-98.
9. Jaksch M, Uzunel M, Martinez Cangana G, Remberger M, Mattsson J. Increased levels of immune transcript in patients with acute GvHD after allogeneic stem cell transplantation. Bone Marrow Transplant 2003; 31: 183-190.
10. Jaksch M, Remberger M, Mattsson J. Increased immune transcript levels are correlated with acute graft-versus-host disease and cytomegalovirus response after allogeneic stem cell transplantation. Transplantation 2004; 77: 195-200.
11. Kircher B, Hack CE, Dickinson AM, Wang XN, Oudshoorn M, Sachs A et al. Towards functional transplant donor matching by measurement of granzyme A and granzyme B production levels. J Immunol Methods 2004; 293: 51-59.
12. Nachbaur D, Eibl B, Kropshofer G, Meister B, Mitterschiffthaler A, Schennach H et al. In vivo T cell depletion with low-dose rabbit antithymocyte globulin results in low transplant-related mortality and low relapse incidence following unrelated hematopoietic stem cell transplantation. J Hematother Stem Cell Res 2002; 11: 731-737.
13. Kaplan EL, Meier P. Non-parametric estimation from incomplete observations. J Am Stat Assoc 1958; 53: 457-481.
14. Spaeny-Dekking EHA, Hanna WL, Wolbink AM, Wever PC, Kummer AJ, Swaak AJG et al. Extracellular granzymes A and B in humans: Detection of native species during CTL responses in vitro and in vivo. J Immunol 1998; 160: 3610-3616.
15. Clément MV, Haddad P, Soulié A, Benvenuti C, Lichtenheld MG, Podack ER et al. Perforin and granzyme B as markers for acute rejection in heart transplantation. Int Immunol 1991; 3: 1175-1181.
16. Griffiths GM, Namikawa R, Mueller C, Liu C-C, Young J D-E, Billingham M et al. Granzyme A and perforin as markers for rejection in cardiac transplantation. Eur J Immunol 1991; 21: 687-693.
17. Cashion AK, Sabek OM, Driscoll CJ, Gaber LW, Gaber AO. Serial peripheral blood cytotoxic lymphocyte gene expression measurements for prediction of pancreas transplant rejection. Transplant Proc 2006; 38: 3676-3677.
18. Kummer JA, Wever PC, Kamp AM, ten Berge IJ, Hack CE, Weening JJ. Expression of granzyme A and B proteins by cytotoxic lymphocytes involved in acute renal allograft rejection. Kidney Int 1995; 47: 70-77.
19. Veale JL, Liang LW, Zhang Q, Gjertson DW, Du Z, Bloomquist EW et al. Noninvasive diagnosis of cellular and antibody-mediated rejection by perforin and granzyme B in renal allografts. Hum Immunol 2006; 67: 7777-7786.
20. Strehlau J, Pavlakis M, Lipman M, Maslinski W, Shapiro M, Strom TB. The intragraft gene activation of markers reflecting T-cell-activation and -cytotoxicity analyzed by quantitative RT-PCR in renal transplantation. Clin Nephrol 1996; 46: 30-33.
21. Inkinen K, Lahesmaa R, Brandt A, Katajamaa M, Halme L, Hockerstedt K et al. DNA microarray-based gene expression profiles of cytomegalovirus infection and acute rejection in liver transplants. Transplant Proc 2005; 37: 1227-1229.
22. Clément MV, Legros-Maïda S, Israël-Biet D, Carnot F, Soulié A, Reynaud P et al. Perforin and granzyme B expression is associated with severe acute rejection. Evidence for in situ localization in alveolar lymphocytes of lung-transplanted patients. Transplantation 1994; 57: 322-326.
23. Bittmann I, Müller C, Behr J, Groetzner J, Frey L, Löhrs U. Fas/FasL and perforin/granzyme pathway in acute rejection and diffuse alveolar damage after allogeneic lung transplantation - a human biopsy study. Virchows Arch 2004; 445: 375-381.
24. Han D, Xu X, Baidal D, Leith J, Ricordi C, Alejandro R et al. Assessment of cytotoxic lymphocyte gene expression in the peripheral blood of human islet allograft recipients: Elevation precedes clinical evidence of rejection. Diabetes 2004; 53: 2281-2290.
25. Altimari A, Gruppioni E, Capizzi E, Bagni A, Corti B, Fiorentino M et al. Blood monitoring of granzyme B and perforin expression after intestinal transplantation: Considerations on clinical relevance. Transplantation 2008; 85: 1778-1783.
26. ten Berge IJ, Wever PC, Wolbink AM, Surachno J, Wertheim PM, Spaeny LH et al. Increased systemic levels of soluble granzymes A and B during primary cytomegalovirus infection after renal transplantation. Transplant Proc 1998; 30: 3972-3974.
27. Wever PC, Spaeny LH, van der Vliet HJ, Rentenaar RJ, Wolbink AM, Surachno J et al. Expression of granzyme B during primary cytomegalovirus infection after renal transplantation. J Infect Dis 1999; 179: 693-696.
28. Rowshani AT, Strik MC, Molenaar R, Yong SL, Wolbink AM, Bemelman FJ et al. The granzyme B inhibitor SERPINB9 (proteinase inhibitor 9) circulates in blood and increases on primary cytomegalovirus infection after renal transplantation. J Infect Dis 2005; 192: 1908-1911.
29. Pan L, Teshima T, Hill GR, Bungard D, Brinson YS, Reddy VS et al. Granulocyte colony-stimulating factor-mobilized allogeneic stem cell transplantation maintains graft-versusleukemia effects through a perforin-dependent pathway while preventing graft-versus-host disease. Blood 1999; 93: 4071-4078.
30. Tsukada N, Kobata T, Aizawa Y, Yagita H, Okumura K. Graft-versus-leukemia effect and graft-versus-host disease can be differentiated by cytotoxic mechanisms in a murine model of allogeneic bone marrow transplantation. Blood 1999; 93: 2738-2747.
31. Hsieh MH, Korngold R. Differential use of FasL- and perforin-mediated cytolytic mechanisms by T-cell subsets involved in graft-versus-myeloid leukemia responses. Blood 2000; 96: 1047-1055.