The Cardiac Renin Receptors

Renin Angiotensin System and the Heart

Volumn , Issue , 2006, Pages 75-83

  Nguyen, Geneviève ^a   Burckle, Céline ^a   Tremey, Benjamin ^a  

^a INSERM   (France)

Author keywords

Aspartyl protease; Cloning renin receptor; M6P receptor role; Receptor bound (pro)renin activity; Renin angiotensin system (RAS); Renin binding proteins; Renin receptor in tissue RAS; Tissue renin angiotensin system

Indexed keywords

EID: 67349284365     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/0470032103.ch6     Document Type: Chapter

References (7)

1. The Heart Outcomes Prevention Evaluation Study Investigators (HOPE) (2000) Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. New England Journal of Medicine 342, 145-153.
2. Tsuchida S, Matsusaka T, Chen X, et al. (1998) Murine double nullizygotes of the angiotensin type 1A and 1B receptors genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. Journal of Clinical Investigation 101, 755-760.
3. van den Eijnden MMED, Saris JJ, de Bruin RJA, et al. (2001) Prorenin accumulation and activation in human endothelial cells. Importance of the mannose-6- phosphate receptors. Arteriosclerosis, Thrombosis and Vascular Biology 21, 911-916.
4. van Kesteren CAM, Danser AHJ, Derkx FH, et al. (1997) Mannose-6-phosphate receptor mediated internalization and activation of prorenin by cardiac cells. Hypertension 30, 1389-1396.
5. Véniant M, Ménard J, Bruneval P, et al. (1996) Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver. Journal of Clinical Investigation 98, 1966-1970.
6. Wagner J, Danser AHJ, Derkx FH, et al. (1996) Demonstration of renin mRNA, angiotensinogen mRNA, and angiotensin converting enzyme mRNA expression in the human eye: evidence for an intraocular renin-angiotensin system. British Journal of Ophtalmology 80, 159-163.
7. Yanai K, Saito T, Kakimuna Y, Kon Y, et al. (2000) Renin-dependent cardiovascular functions and renin-independent blood-brain barrier function revealed by renin-deficient mice. Journal of Biological Chemistry 275, 5-8.