Synthesis and in vitro antitumor activities of novel 4-anilinoquinazoline derivatives

European Journal of Medicinal Chemistry

Volumn 44, Issue 7, 2009, Pages 3046-3055

  Chandregowda, Venkateshappa ^a   Kush, A K ^a   Chandrasekara Reddy, G ^a  

^a JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

4 Anilinoquinazoline; A431 and MCF 7 cell lines; Cytotoxicity; Insilico analysis

Indexed keywords

1 [3 [4 (3 BROMOPHENYLAMINO) 7 METHOXYQUINAZOLIN 6 YLOXY]PROPYL] 2 BUTYL 4 CHLORO 1H IMIDAZOLE 5 CARBOXALDEHYDE; 1 [3 [4 (4 BROMO 2 ETHYLPHENYLAMINO) 7 METHOXYQUINAZOLIN 6 YLOXY]PROPYL] 2 BUTYL 4 CHLORO 1H IMIDAZOL 5 YL]METHANOL; 1 [3 [4 (4 BROMO 2 ETHYLPHENYLAMINO) 7 METHOXYQUINAZOLIN 6 YLOXY]PROPYL] 2 BUTYL 4 CHLORO 1H IMIDAZOLE 5 CARBOXALDEHYDE; 2 BUTYL 4 CHLORO 1 [3 [4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 METHOXYQUINAZOLIN 6 YLOXY]PROPYL] 1H IMIDAZOLE 5 CARBOXALDEHYDE; 2 BUTYL 4 CHLORO 1 [3 [4 (3 ETHYNYLPHENYLAMINO) 7 METHOXYQUINAZOLIN 6 YLOXY]PROPYL] 1H IMIDAZOLE 5 CARBOXALDEHYDE; 2 BUTYL 4 CHLORO 1 [3 [4 (3 FLUOROPHENYLAMINO) 7 METHOXYQUINAZOLIN 6 YLOXY]PROPYL] 1H IMIDAZOLE 5 CARBOXALDEHYDE; 2 BUTYL 4 CHLORO 1 [3 [4 (3 IODOPHENYLAMINO) 7 METHOXYQUINAZOLIN 6 YLOXY]PROPYL] 1H IMIDAZOLE 5 CARBOXALDEHYDE; 2 BUTYL 4 CHLORO 1 [3 [7 METHOXY 4 (3 TRIFLUOROMETHYLPHENYLAMINO)QUINAZOLIN 6 YLOXY]PROPYL] 1H IMIDAZOLE 5 CARBOXALDEHYDE; 2 BUTYL 4 CHLORO 1 [3 [7 METHOXY 4 (4 METHOXYPHENYLAMINO)QUINAZOLIN 6 YLOXY]PROPYL] 1H IMIDAZOLE 5 CARBOXALDEHYDE; 6 [3 (BENZOTHIAZOL 2 YLTHIO)PROPOXY] 7 METHOXY N(3 TRIFLUOROMETHYLPHENYL)QUINAZOLIN 4 AMINE; 6 [3 (BENZOTHIAZOL 2 YLTHIO)PROPOXY] 7 METHOXY N(4 METHOXYPHENYL)QUINAZOLINE 4 AMINE; 6 [3 (BENZOTHIAZOL 2 YLTHIO)PROPOXY] 7 METHOXY N(4 METHYLPHENYL)QUINAZOLIN 4 AMINE; 6 [3 (BENZOTHIAZOL 2 YLTHIO)PROPOXY]N(3 CHLORO 4 FLUOROPHENYL) 7 METHOXYQUINAZOLIN 4 AMINE; 6 [3 (BENZOTHIAZOL 2 YLTHIO)PROPOXY]N(4 BROMO 2 ETHYLPHENYL) 7 METHOXYQUINAZOLIN 4 AMINE; 6 [3 (BENZOXAZOL 2 YLTHIO)PROPOXY] 7 METHOXY N(3 TRIFLUOROMETHYLPHENYL)QUINAZOLIN 4 AMINE; 6 [3 (BENZOXAZOL 2 YLTHIO)PROPOXY] 7 METHOXY N(4 METHOXYPHENYL)QUINAZOLIN 4 AMINE; 6 [3 (BENZOXAZOL 2 YLTHIO)PROPOXY] 7 METHOXY N(4 METHYLPHENYL)QUINAZOLIN 4 AMINE; 6 [3 (BENZOXAZOL 2 YLTHIO)PROPOXY] 7 METHOXY N(4 TRIFLUOROMETHOXYPHENYL)QUINAZOLIN 4 AMINE; 6 [3 (BENZOXAZOL 2 YLTHIO)PROPOXY]N(3 CHLORO 4 FLUOROPHENYL) 7 METHOXY QUINAZOLIN 4 AMINE; 6 [3 (BENZOXAZOL 2 YLTHIO)PROPOXY]N(4 BROMO 2 ETHYLPHENYL) 7 METHOXY QUINAZOLIN 4 AMINE; [1 [3 [4 (3 BROMOPHENYLAMINO) 7 METHOXYQUINAZOLIN 6 YLOXY]PROPYL] 2 BUTYL 4 CHLORO 1H IMIDAZOL 5 YL]METHANOL; [2 BUTYL 4 CHLORO 1 [3 (4 (3 CHLORO 4 FLUOROPHENYLAMINO) 7 METHOXY QUINAZOLIN 6 YLOXY)PROPYL] 1H IMIDAZOL 5 YL]METHANOL; [2 BUTYL 4 CHLORO 1 [3 [4 (3 ETHYNYLPHENYLAMINO) 7 METHOXYQUINAZOLIN 6 YLOXY]PROPYL] 1H IMIDAZOL 5 YL]METHANOL; [2 BUTYL 4 CHLORO 1 [3 [4 (3 FLUOROPHENYLAMINO) 7 METHOXYQUINAZOLIN 6 YLOXY]PROPYL] 1H IMIDAZOL 5 YL]METHANOL; [2 BUTYL 4 CHLORO 1 [3 [4 (3 IODOPHENYLAMINO) 7 METHOXYQUINAZOLIN 6 YLOXY]PROPYL] 1H IMIDAZOL 5 YL]METHANOL; [2 BUTYL 4 CHLORO 1 [3 [7 METHOXY 4 (3 TRIFLUOROMETHYLPHENYLAMINO)QUINAZOLIN 6 YLOXY]PROPYL] 1H IMIDAZOL 5 YL]METHANOL; [2 BUTYL 4 CHLORO 1 [3 [7 METHOXY 4 (4 METHOXYPHENYLAMINO)QUINAZOLIN 6 YLOXY]PROPYL] 1H IMIDAZOL 5 YL]METHANOL; ANTINEOPLASTIC AGENT; GEFITINIB; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PROTEIN EXPRESSION; SKIN CARCINOMA; SQUAMOUS CELL CARCINOMA;

ANILINE COMPOUNDS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; NEOPLASMS; PHOSPHOTRANSFERASES; PROTEIN STRUCTURE, TERTIARY; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR;

EID: 67349283415     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.07.023     Document Type: Article

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