A novel antioxidant 3,7-dihydroxy-isoflav-3-ene (DHIF) inhibits neointimal hyperplasia after vessel injury attenuating reactive oxygen species and nuclear factor-κB signaling

Atherosclerosis

Volumn 204, Issue 1, 2009, Pages 66-72

  Kanellakis, Peter ^a   Pomilio, Giovanna ^a   Walker, Catherine ^b   Husband, Alan ^b   Huang, Jiu Li ^b   Nestel, Paul ^a   Agrotis, Alex ^a   Bobik, Alex ^a  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b Novogen Ltd   (Australia)

Author keywords

Cyclooxygenase; Neointima; NF B; Superoxide; Vessel injury

Indexed keywords

3,7 DIHYDROXY ISOFLAV 3 ENE; ANTIOXIDANT; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOFLAVONE DERIVATIVE; MONOCYTE CHEMOTACTIC PROTEIN 1; REACTIVE OXYGEN METABOLITE; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTERY INJURY; ARTERY INTIMA PROLIFERATION; ARTICLE; BALLOON CATHETER; CAROTID ARTERY; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BALLOON DILATATION; BENZOPYRANS; CAROTID ARTERIES; CAROTID ARTERY INJURIES; CELL PROLIFERATION; CHEMOKINE CCL2; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; HYPERPLASIA; MUSCLE, SMOOTH, VASCULAR; OXIDATIVE STRESS; PLATELET-DERIVED GROWTH FACTOR; RABBITS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUPEROXIDES; TIME FACTORS; TRANSCRIPTION FACTOR RELA; TUNICA INTIMA;

EID: 67349279798     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2008.09.005     Document Type: Article

References (36)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362 (1993) 801-809
2. Lowe H.C., Oesterles N., and Khachigian L.M. Coronary in-stent restenosis: current status and future strategies. J Am Coll Cardiol 39 (2002) 183-193
3. Abahji T.N., Tato F., Rieger J., et al. Stenting of the superficial femoral artery after suboptimal balloon angioplasty: on-year results. Int Angiol 25 (2006) 184-189
4. Wong J., Rauhoft C., Dilley D.J., Agrotis A., Jennings G.L., and Bobik A. Angiotensin converting enzyme inhibition abolishes medial smooth muscle PDGF-AB biosynthesis and attenuates their proliferation. Circ 96 (1997) 1621-1640
5. Agrotis A., Kanellakis P., Kostolias G., et al. Proliferation of neointimal smooth muscle cells after vessel injury. Dependency on interactions between fibroblast growth factor receptor-2 and fibroblast growth factor-9. J Biol Chem 279 (2004) 42221-42229
6. Kanellakis P., Nestel P., and Bobik A. Angioplasty-induced superoxide anions and neointimal hyperplasia in the rabbit carotid artery: suppression by the isoflavone trans-tetrahydrodiadzein. Atherosclerosis 176 (2004) 63-72
7. Dourron H.M., Jacobson G.M., Park J.L., et al. Perivascular gene transfer of NADPH oxidase inhibitor suppresses angioplasty-induced neointimal proliferation of rat carotid artery. Am J Physiol 288 (2005) H946-H953
8. Matesanz N., Lafuente N., Azcutia V., et al. Xanthine oxidase-derived extracellular superoxide anions stimulate activator protein 1 activity and hypertrophy in human vascular smooth muscle via c-jun N-terminal kinase and p38 mitogen-activated protein kinases. J Hypertens 25 (2007) 609-618
9. Callsen D., Sandau K.B., and Brune B. Nitric oxide and superoxide inhibit platelet-derived growth factor receptor phosphotyrosine phosphatases. Free Radic Biol Med 26 (1999) 1544-1553
10. Marumo T., Schini-Kerth V.B., Fissithaler B., and Busse R. Platelet-derived growth factor-stimulated superoxide anion production modulates activation of transcription factor NF-kappaB and expression of monocyte chemoattractant protein 1 in human aortic smooth muscle cells. Circulation 96 (1997) 2361-2367
11. Landry D.B., Couper L.L., Bryant S.R., and Lindner V. Activation of the NF-κB and IκB system in smooth muscle cells after rat arterial injury. Am J Pathol 151 (1997) 1085-1095
12. Miyake T., Aoki M., Shiraya S., et al. Inhibitory effects of NFkappaB decoy oligodeoxynucleotides on neointimal hyperplasia in a rabbit vein graft model. J Mol Cell Cardiol 41 (2006) 431-440
13. Orlandi A., Francesconi A., Marcellini M., di Lascio A., and Spagnolli L.G. Propionyl-l-carnitine reduces proliferation and potentiates Bax-related apoptosis of aortic intima smooth muscle cells by modulating nuclear factor-κB activity. J Biol Chem 282 (2007) 4932-4942
14. Bendeck M.P., Zempo N., Clowes A.W., Galardy R.E., and Reidy M.A. Smooth muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat. Circ Res 75 (1994) 539-545
15. Ueno H., Kanellakis P., Agrotis A., and Bobik A. Blood flow regulates the development of vascular hypertrophy, smooth muscle cell proliferation and endothelial cell nitric oxide synthase in hypertension. Hypertension 36 (2000) 89-96
16. Brar S.S., Kennedy T.P., Sturrock A.B., et al. NADPH oxidase promotes NF-kappaB activation and proliferation in human airway smooth muscle. Am J Physiol 282 (2002) L782-L795
17. Kucharczak J., Simmons M.J., Fan Y., and Gelinas C. To be or not to be: NF-κB is the answer-role of Rel/NF-κB in the regulation of apoptosis. Oncogene 22 (2003) 8961-8982
18. Leskinen M.J., Heikkila H.M., Speer M.Y., et al. Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-κB-mediated survival signalling. Exp Cell Res 312 (2006) 1289-1298
19. Connolly E., Bouchier-Hayes D.J., Kaye E., Leahy A., Fitzgerald D., and Belton O. Cyclooxygenase isozyme expression and intimal hyperplasia in a rat model of balloon angioplasty. J Pharmacol Exp Ther 300 (2002) 393-398
20. Peng T., Lu X., and Feng Q. NADH oxidase signalling induces cyclooxygenase-2 expression during lipopolysaccharide stimulation in cardiomyocytes. FASEB J 19 (2005) 293-295
21. Rious N., and Castonguay A. The induction of cyclooxygenase-1 by a tobacco carcinogen in U937 human macrophages is correlated to the activation of NF-κB. Carcinogenesis 21 (2000) 1745-1751
22. Koyama H., and Reidy M.A. Reinjury of arterial lesions induces intimal smooth muscle cell replication that is not controlled by fibroblast growth factor 2. Circ Res 80 (1997) 408-417
23. Szocs K., Lassegue B., Sorescu D., et al. Upregulation of nox-based NAD(P)H oxidase and reactive oxygen species in coronary arteries after balloon injury. Arterioscler Thromb Vasc Biol 22 (2002) 21-27
24. Miller F.J., Filali M., Huss G.J., et al. Cytokine activation of nuclear factor kappaB in vascular smooth muscle cells requires signaling endosomes containing Nox1 and CIC-3. Circ Res 101 (2007) 663-671
25. Guttridge D.C., Albanese C., Reuther J.Y., Pestell R.G., and Baldwin A.S. NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol 19 (1999) 5785-5799
26. Usui M., Egashira K., Ohtani K., et al. Anti-monocyte chemoattractant protein-1 therapy inhibits restenotic changes (neointima hyperplasia) after balloon injury in rats and monkeys. FASEB J 16 (2002) 1838-1840
27. Jay D.B., Papaharalambus A., Seidel-Rogol B., Dikalova A.E., Lassegue B., and Griendling K.K. Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells. Free Radic Biol Med 45 (2008) 329-335
28. Haysahi K., Takahata H., Kitagawa n, Kitange G., Kaminogo M., and Shibata S. N-acetylcysteine inhibited nuclear factor-kappaB expression and the intimal hyperplasia in rat carotid arterial injury. Neurol Res 23 (2001) 731-738
29. Ueberla K., Lu Y., Chung E., and Haseltine W.A. The NF-kappa B p65 promoter. J Acquir Immune Defic Syndr 6 (1993) 227-230
30. Ahn K.S., Sethi G., Krishnan K., and Aggarwal B.B. γ-Tocotrienol inhibits nuclear factor-κB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. J Biol Chem 282 (2007) 809-820
31. Andres V., and Castro C. antiproliferative strategies for the treatment of vascular proliferative disease. Curr Vasc Pharmacol 1 (2003) 85-98
32. Younes A., Ayoub J.P., Sarris A., et al. Paclitaxel activity for the treatment of non-Hodgkin's lymphoma: final report of a phase II trial. Br J Haematol 96 (1997) 328-332
33. Stone G.W., Moses J.W., Ellis S.G., et al. Safety and efficacy of sirolimus- and paclitaxel-eluting coronary stents. N Engl J Med 356 (2007) 998-1008
34. Jeremias A., Dusa C., Forudi F., et al. N-acetyl-cysteine in the prevention of vascular restenosis after percutaneous balloon angioplasty. Int J Cardiol 95 (2004) 255-260
35. Suzuki J., Iwai M., Mogi M., et al. Epleronone with valsartan effectively reduces atherosclerotic lesion by attenuation of oxidative stress and inflammation. Arterioscler Thromb Vasc Biol 26 (2006) 917-921
36. -/- mice. Arterioscler Thromb Vasc Biol 28 (2008) 272-277