Evaluation of in vivo wound-healing potential of 2-[4-(2,4-dimethoxy-benzoyl)-phenoxy]-1-[4-(3-piperidin-4-yl-propyl)-piperidin-1-yl]-ethanone derivatives

European Journal of Medicinal Chemistry

Volumn 44, Issue 8, 2009, Pages 3158-3165

  Vinaya, K ^a   Naika, H Raja ^b   Ananda Kumar, C S ^a   Benaka Prasad, S B ^a   Chandrappa, S ^a   Ranganatha, S R ^a   Krishna, V ^b   Rangappa, K S ^a  

^a UNIVERSITY OF MYSORE   (India)

^b School of Chemical Sciences   (India)

Author keywords

Granulation; Piperidine; Wound healing

Indexed keywords

2 [4 (2,4 DIMETHOXYBENZOYL)PHENOXY] 1 [4 (3 PIPERIDIN 4 YLPROPYL)PIPERIDIN 1 YL]ETHANONE DERIVATIVE; 4 [3 [1 [2 [4 (2,4 DIMETHOXYBENZOYL)PHENOXY]ACETYL] 4 PIPERIDYL]PROPYL] N (2 CHLOROPHENYL)PIPERIDINE 1 CARBOTHIOAMIDE; 4 [3 [1 [2 [4 (2,4 DIMETHOXYBENZOYL)PHENOXY]ACETYL] 4 PIPERIDYL]PROPYL] N (2 CHLOROPHENYL)PIPERIDINE 1 CARBOXAMIDE; 4 [3 [1 [2 [4 (2,4 DIMETHOXYBENZOYL)PHENOXY]ACETYL] 4 PIPERIDYL]PROPYL] N (2,4 DICHLOROPHENYL)PIPERIDINE 1 CARBOTHIOAMIDE; 4 [3 [1 [2 [4 (2,4 DIMETHOXYBENZOYL)PHENOXY]ACETYL] 4 PIPERIDYL]PROPYL] N (2,4 DICHLOROPHENYL)PIPERIDINE 1 CARBOXAMIDE; 4 [3 [1 [2 [4 (2,4 DIMETHOXYBENZOYL)PHENOXY]ACETYL] 4 PIPERIDYL]PROPYL] N (4 FLUOROPHENYL)PIPERIDINE 1 CARBOTHIOAMIDE; 4 [3 [1 [2 [4 (2,4 DIMETHOXYBENZOYL)PHENOXY]ACETYL] 4 PIPERIDYL]PROPYL] N (4 FLUOROPHENYL)PIPERIDINE 1 CARBOXAMIDE; 4 [3 [1 [2 [4 (2,4 DIMETHOXYBENZOYL)PHENOXY]ACETYL] 4 PIPERIDYL]PROPYL] N (4 METHOXYPHENYL)PIPERIDINE 1 CARBOTHIOAMIDE; 4 [3 [1 [2 [4 (2,4 DIMETHOXYBENZOYL)PHENOXY]ACETYL] 4 PIPERIDYL]PROPYL] N (4 METHOXYPHENYL)PIPERIDINE 1 CARBOXAMIDE; COLLAGEN; NITROFURAL; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; EPITHELIZATION; GRANULATION TISSUE; HISTOLOGY; IN VIVO STUDY; INFRARED SPECTROSCOPY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; OINTMENT; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STATISTICAL ANALYSIS; STRUCTURE ACTIVITY RELATION; SUSPENSION; TENSILE STRENGTH; WOUND; WOUND CONTRACTION; WOUND HEALING;

ADMINISTRATION, ORAL; ANIMALS; FEMALE; MALE; MODELS, BIOLOGICAL; PIPERIDINES; RATS; RATS, WISTAR; WOUND HEALING; WOUNDS AND INJURIES;

EID: 67349278802     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.03.012     Document Type: Article

References (42)

1. Mertz P., and Ovington L. Dermatol. Clin. 11 (1993) 739-747
2. Chattopadhyay D., Arunachalam G., Mandal A.B., Sur T.K., Mandal S.C., and Bhattacharya S.K. J. Ethnopharmacol. 82 (2002) 229-237
3. Stadelman W.K., Digents A.G., and Tobin G.R. Am. J. Surg. 176 (1998) 265-269
4. Iba Y., Shibata A., Kato M., and Masukawa T. Int. Immunopharmacol. 4 (2004) 1873-1880
5. Jahovic N., Guzel E., Arbak S., and Yegen B.C. Burns 30 (2004) 531-538
6. Atta-ur-Rahman. In: Angle S.R., and Breitenbucher J.G. (Eds). Stereoselective Synthesis (1995), Elsevier, New York 453-502
7. In: Pelletier S.W., and Schneider M.J. (Eds). Chemical and Biological Perspectives (1996), Wiley, New York 155-355
8. Kartritzky A.R., and Fan W.Q. J. Org. Chem. 55 (1990) 3205-3209
9. Mobia I.G., Soldatendkov A.T., Fedorov V.O., Ageev E.A., Sergeeva N.D., Lin S., Stashenko E.E., Prostakov N.S., and Andreeva E.I. Khim. Farm. Zh. 23 (1989) 421-427
10. C.N. Nalini, M.Pharm. Dissertation, The Tamil Nadu Dr. M.G.R. Medical University, India, 1997.
11. Georgiev V., and Petkova B. Acta Physiol. Pharmacol. Bulg. 2 (1974) 76-81
12. Vankov S., and Nachnoizsled J. Khim. Farm. Inst. 9 (1974) 231-235
13. Severs W.B., Kinnard W.J., and Buckley J.P. J. Pharm. Sci. 54 (1965) 1025-1031
14. IsKarev N.A., and Shadurshkii K.S. Farmakol. Toksikol. 28 (1965) 184-188
15. Ileana B., Dobre V., and Duaz N.J. J. Prakt. Chem. 327 (1985) 667-674
16. Ganellin C.R., and Spickett R.G.W. J. Med. Chem. 8 (1965) 619-625
17. Shen S.Y., Tsai H.J., and Chiang H.C. Anticancer Res. 19 (1999) 1131-1135
18. Burns D.T., Tungkananuruk N., and Thuwasin S. Anal. Chim. Acta 419 (2000) 41-48
19. Palomer A., Perez J.J., Navea S., Llorens O., Pascual J., Garcia M.L., and Mauleon D.M. J. Med. Chem. 43 (2000) 2280-2284
20. J. Jiri, P. Miroslav, P. Josef, W. Stanislav. Csech CS, 271,185, 1991, through
21. Chem. Abstr. 117 (1992) 170994d
22. Williams M., Kowaluk E.A., and Arneric S.P. J. Med. Chem. 42 (1999) 1481-1500
23. I. Yoshiyuki, K. Miwako, K. Shusuke, Jpn. Kokai Tokkya Koho JP, 03,209,318, 1991 through
24. Chem. Abstr. 116 (1992) 99311a
25. Silverman R.B. Organic Chemistry of Drug Design and Drug Action (1992), Academic Press, San Diego
26. Thompson L.A., and Ellman J.A. Chem. Rev. 96 (1996) 555-600
27. Robert G.F. J. Comb. Chem. 2 (2000) 195-214
28. Rosenberg E.W. Arch. Dermatol. 704 (1971) 629-632
29. Schlagel C.A., and Northam J.I. Proc. Soc. Exp. Biol. Med. 101 (1959) 629-632
30. Howes E.L., Ploiz C.M., Blunt J.W., and Raoan C. Surgery 28 (1950) 177-181
31. Ehrlich H.P., and Thomas K.H. Ann. Surg. 167 (1968) 324-328
32. G.P. Bharath, Practical manual for pharmaceutics. Vol. 1 sixth ed. Sumitha Publications, Shimoga, Karnataka, India, 1996, pp. 108-109.
33. Ghosh M.N. Fundamentals of Experimental Pharmacology (1984), Scientific Book Agency, Kolkata
34. Ehrlich H.P., and Hunt T.K. Ann. Surg. 57 (1968) 117-122
35. Lee K.H., and Tong T.G. J. Pharm. Sci. 57 (1968) 1042-1043
36. Kanai L., and Mukherjee. Medical Laboratory Technology (2000), Tata McGraw Hill Ltd, New Delhi
37. Madden J.W., and Peacock E.E. Surgery 64 (1968) 288-294
38. Schultz G.S., Sibbald R.G., Falanga V., Ayello E.A., Dowsett C., Harding K., Romanelli M., Stacey M.C., Teot L., and Vanscheidt W. Wound Repair Regen. 11 (2003) S1-S28
39. Shirwaikar A., Shenoy R., Udupa A.L., Udupa S.L., and Shetty S. Indian J. Exp. Biol. Med. 41 (2003) 238-241
40. Singh S.D.J., Krishna V., Mankani K.L., Manjunath B.K., Vidya S.M., and Manohara Y.N. Indian J. Pharmacol. 4 (2005) 238-242
41. Azad S. Essentials of Surgery (2002), Paras Medical Publications, Hyderabad p. 1
42. Vinaya K., Naika R., Ananda Kumar C.S., Benaka Prasad S.B., Chandrappa S., Ranganatha S.R., Krishna V., and Rangappa K.S. Lett. Drug Design Discov. 5 (2008) 250-260