The winged-helix transcription factor JUMU is a haplo-suppressor/triplo- enhancer of PEV in various tissues but exhibits reverse PEV effects in the brain of Drosophila melanogaster

Chromosome Research

Volumn 17, Issue 3, 2009, Pages 347-358

  Hofmann, Annemarie ^a   Brünner, Madeleine ^a   Korge, Günter ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Drosophila; Gene dosage effects; Gene silencing; Jumeaux; Position effect variegation

Indexed keywords

TRANSCRIPTION FACTOR JUMU; UNCLASSIFIED DRUG; WINGED HELIX TRANSCRIPTION FACTOR;

ANIMAL TISSUE; ARTICLE; BRAIN TISSUE; CONTROLLED STUDY; DOSE RESPONSE; DROSOPHILA MELANOGASTER; ENHANCER REGION; FEMALE; GENE DOSAGE; GENE FUNCTION; GENE SILENCING; LARVA; MALE; NONHUMAN; POSITION EFFECT VARIEGATION; PRIORITY JOURNAL; SUPPRESSOR GENE;

ANIMALS; BETA-GALACTOSIDASE; BRAIN; CHROMATIN; CHROMOSOMAL POSITION EFFECTS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; REPRESSOR PROTEINS; TRANSCRIPTION FACTORS;

DROSOPHILA MELANOGASTER;

EID: 67349277405     PISSN: 09673849     EISSN: 15736849     Source Type: Journal    
DOI: 10.1007/s10577-009-9026-1     Document Type: Article

References (39)

1. HJ Bellen CJ O'Kane C Wilson 1989 P-element-mediated enhancer detection: a versatile method to study development in Drosophila Genes Dev 3 1288 1300
2. AH Brand N Perrimon 1993 Targeted gene expression as a means of altering cell fates and generating dominant phenotypes Development 118 401 415 (Pubitemid 23214028)
3. PY Cheah W Chia X Yang 2000 Jumeaux, a novel Drosophila winged-helix family protein, is required for generating asymmetric sibling neuronal cell fates Development 127 3325 3335 (Pubitemid 30649544)
4. F Cleard M Delattre P Spierer 1997 SU(VAR)3-7, a Drosophila heterochromatin-associated protein and companion of HP1 in the genomic silencing of position-effect variegation EMBO J 16 5280 5288 (Pubitemid 27380136)
5. R Dorn J Szidonya G Korge 1993 P transposon-induced dominant enhancer mutations of position-effect variegation in Drosophila melanogaster Genetics 133 279 290 (Pubitemid 23033483)
6. JC Eissenberg TC James DM Foster-Hartnett V 1990 Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster Proc Natl Acad Sci U S A 87 9923 9927 (Pubitemid 120016556)
7. JC Eissenberg GD Morris G Reuter T Hartnett 1992 The heterochromatin- associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation Genetics 131 345 352
8. L Giot JS Bader C Brouwer 2003 A protein interaction map of Drosophila melanogaster Science 302 1727 1736 (Pubitemid 37505730)
9. SL Gregory T Shandala L O'Keefe L Jones MJ Murray R Saint 2007 A Drosophila overexpression screen for modifiers of Rho signalling in cytokinesis Fly 1 13 22
10. E Heitz 1928 Das Heterochromatin der Moose Jb Wiss Bot 69 728 818
11. S Henikoff 1996 Dosage-dependent modification of position-effect variegation in Drosophila BioEssays 18 401 409 (Pubitemid 126599965)
12. JB Kearney SR Wheeler P Estes ST Crews 2004 Gene expression profiling of the developing Drosophila CNS midline cells Dev Biol 275 473 492 (Pubitemid 40288100)
13. Lindsley DT, Zimm GG (1992) The Genome of Drosophila melanogaster. Academic Press, San Diego
14. J Locke MA Kotarski KD Tartof 1988 Dosage-dependent modifiers of position effect variegation in Drosophila and a mass action model that explains their effect Genetics 120 181 198 (Pubitemid 18222288)
15. BY Lu CP Bishop JC Eissenberg 1996 Developmental timing and tissue specificity of heterochromatin-mediated silencing EMBO J 15 1323 1332 (Pubitemid 26093468)
16. BY Lu J Ma JC Eissenberg 1998 Developmental regulation of heterochromatin-mediated gene silencing in Drosophila Development 125 2223 2234 (Pubitemid 28336384)
17. MF Lyon 1961 Gene action in the X-chromosome of the mouse (Mus musculus L.) Nature 190 372 373
18. HJ Muller 1930 Types of visible variations induced by X-rays in Drosophila J Genet 22 299 334
19. Patel NH (1994) Imaging neuronal subsets and other cell types in whole-mount Drosophila embryos and larvae using antibody probes. In: Goldstein LSB, Fyrberg EA (eds.) Methods in Cell Biology, Vol. 44. Academic Press, pp. 445-487
20. G Reuter J Szidonya 1983 Cytogenetic analysis of variegation suppressors and a dominant temperature-sensitive lethal in region 23-26 of chromosome 2L in Drosophila melanogaster Chromosoma 88 277 285 (Pubitemid 14235278)
21. G Reuter I Wolff 1981 Isolation of dominant suppressor mutations for position-effect variegation in Drosophila melanogaster Mol Gen Genet 182 516 519
22. G Reuter HJ Hoffmann I Wolff 1983 Genetic study of position-effect variegation in Drosophila melanogaster: In(1)wm4h as a standard rearrangement for the isolation and characterization of suppressor and enhancer mutants Biol Zbl 102 281 298
23. m4 position-effect variegation in Drosophila melanogaster Chromosoma 93 132 139 (Pubitemid 16233592)
24. G Reuter R Dorn G Wustmann B Friebe G Rauh 1986 Third chromosome suppressor of position-effect variegation loci in Drosophila melanogaster Mol Gen Genet 202 481 487
25. EJ Richards SC Elgin 2002 Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects Cell 108 489 500 (Pubitemid 34260874)
26. T Rudolph M Yonezawa S Lein 2007 Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3 Mol Cell 26 103 115 (Pubitemid 46566423)
27. G Schotta A Ebert V Krauss 2002 Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing EMBO J 21 1121 1131 (Pubitemid 34206185)
28. G Schotta A Ebert R Dorn G Reuter 2003 Position-effect variegation and the genetic dissection of chromatin regulation in Drosophila Semin Cell Dev Biol 14 67 75 (Pubitemid 36259937)
29. A Schwendemann T Matkovic C Linke A Klebes A Hofmann G Korge 2008 Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation Proc Natl Acad Sci U S A 105 204 209
30. C Seum A Spierer D Pauli 1996 Position-effect variegation in Drosophila depends on dose of the gene encoding the E2F transcriptional activator and cell cycle regulator Development 122 1949 1956 (Pubitemid 26192758)
31. T Siegmund G Korge 2001 Innervation of the ring gland of Drosophila melanogaster J Comp Neurol 431 481 491 (Pubitemid 32178950)
32. Spofford JB (1976) Position-effect variegation in Drosophila. In: Ashburner M, Novitski E (eds) The Genetics and Biology of Drosophila. Academic Press, New York, pp 955-1018
33. M Stroedicke S Karberg G Korge 2000 Domina (Dom), a new Drosophila member of the FKH/WH gene family, affects morphogenesis and is a suppressor of position-effect variegation Mech Dev 96 67 78 (Pubitemid 30625267)
34. I Sugimura T Adachi-Yamada Y Nishi Y Nishida 2000 A Drosophila Winged-helix nude (Whn)-like transcription factor with essential functions throughout development Dev Growth Differ 42 237 248 (Pubitemid 30456751)
35. B Tschiersch A Hofmann V Krauss R Dorn G Korge G Reuter 1994 The protein encoded by the Drosophila position-effect variegation suppressor gene Su(var)3-9 combines domains of antagonistic regulators of homeotic gene complexes EMBO J 13 3822 3831 (Pubitemid 24275028)
36. K van de Flierdt 1975 No multistrandedness in mitotic chromosomes of Drosophila melanogaster Chromosoma 50 431 434
37. LL Wallrath SC Elgin 1995 Position effect variegation in Drosophila is associated with an altered chromatin structure Genes Dev 9 1263 1277
38. C Wilson RK Pearson HJ Bellen 1989 P-element-mediated enhancer detection: an efficient method for isolating and characterizing developmentally regulated genes in Drosophila Genes Dev 3 1301 1313
39. IF Zhimulev ES Belyaeva 2003 Intercalary heterochromatin and genetic silencing Bioessays 25 1040 1051 (Pubitemid 37411764)