Engineering a GABA endowed with pharmacological CNS activity when given by an extracerebral route

Medicinal Chemistry Research

Volumn 18, Issue 4, 2009, Pages 255-267

  Vamecq, Joseph ^a   Feutelais, Yves ^b   Maurois, Pierre ^b,c   Sghaier, Mehrez ^b   Dichi, Emma ^b   German Fattal, Michèle ^b,c   Herrenknecht, Christine ^b   Gressens, Pierre ^d,e   Cecchelli, Roméo ^f   Dehouck, Lucie ^f   Stables, James P ^g   Pages, Nicole ^h   Legendre, Bernard ^b   Bac, Pierre ^b,c  

^a INSERM   (France)

^b CNRS   (France)

^c CENTRE CHIRURGICAL MARIE LANNELONGUE   (France)

^d HÔPITAL ROBERT DEBRÉ   (France)

^e UNIVERSITÉ PARIS DESCARTES   (France)

^f UNIVERSITÉ D'ARTOIS   (France)

^g NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^h UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Gamma aminobutyric acid (GABA); Gauche conformer; Monoclinic phase; Sublimation under vacuum; Tetragonal phase; Trans conformer

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDIOGENIC SEIZURE; BIOENGINEERING; BLOOD BRAIN BARRIER; CARBON NUCLEAR MAGNETIC RESONANCE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CRYSTALLOGRAPHY; DRUG ACTIVITY; DRUG DESIGN; DRUG IDENTIFICATION; FEMALE; GABAERGIC TRANSMISSION; INFRARED RADIATION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE;

EID: 67349255399     PISSN: 10542523     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00044-008-9124-1     Document Type: Article

References (9)

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