Injection of bleomycin in newborn mice induces autoimmune sialitis that is transferred by CD4 T cells

Immunology and Cell Biology

Volumn 87, Issue 4, 2009, Pages 351-358

  Ishikawa, Hideaki ^a   Ito, Sachiko ^a   Nishio, Naomi ^a   Yuzawa, Yukio ^a   Matsuo, Sei Ichi ^a   Isobe, Ken Ichi ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Animal model; Autoimmunity; Autoreactive CD4+ T cells; Bleomycin; FOXP3; Regulatory T cells

Indexed keywords

AUTOANTIBODY; BLEOMYCIN; CD45 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; BAGG ALBINO MOUSE; CD4+ T LYMPHOCYTE; CLONOGENESIS; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; MOUSE; NEWBORN; NONHUMAN; REGULATORY T LYMPHOCYTE; SIALOADENITIS; SPLEEN;

ADOPTIVE TRANSFER; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; AUTOANTIBODIES; AUTOIMMUNE DISEASES; AUTOIMMUNITY; BLEOMYCIN; CD4-POSITIVE T-LYMPHOCYTES; INFUSIONS, SUBCUTANEOUS; LYMPH NODES; MICE; MICE, INBRED BALB C; SALIVARY GLANDS; SIALADENITIS;

ANIMALIA; MURINAE; MUS; MUS MUSCULUS;

EID: 67349255020     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2009.1     Document Type: Article

References (28)

1. Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immuno 2005; 6:345.
2. Fontenot JD, Rudensky AY. A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat Immunol 2005; 6:331.
3. Su MA, Giang K, Zumer K, Jiang H, Oven I, Rinn JL et al. Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire. JClin Invest 2008; 118:1712.
4. Gray DH, Gavanescu I, Benoist C, Mathis D. Danger-free autoimmune disease in Aire- deficient mice. Proc Natl Acad Sci USA 2007; 104:18193.
5. O'Dwyer DT, McElduff P, Peterson P, Perheentupa J, Crock PA. Pituitary autoantibodies in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED). Acta Biomed 2007; 78 (Suppl 1): 248.
6. Bukilica M, Djordjevic S, Maric I, Dimitrijevic M, Markovic BM, Jankovic BD. Stress- induced suppression of experimental allergic encephalomyelitis in the rat. Int J Neurosci 1991; 59:167.
7. Laban O, Dimitrijevic M, von Hoersten S, Markovic BM, Jankovic BD. Experimental allergic encephalomyelitis in adult DA rats subjected to neonatal handling or gentling. Brain Res 1995; 676:133.
8. Dimitrijevic M, Laban O, von Hoersten S, Markovic BM, Jankovic BD. Neonatal sound stress and development of experimental allergic encephalomyelitis in Lewis and DA rats. Int J Neurosci 1994; 78:135.
9. Chen J, Stubbe J. Bleomycins: towards better therapeutics. Nat Rev Cancer 2005; 5: 102.
10. Bowden DH. Unraveling pulmonary fibrosis: the bleomycin model. Lab Invest 1984; 50:487.
11. Lakos G, Melichian D, Wu M, Varga J. Increased bleomycin-induced skin fibrosis in mice lacking the Th1-specific transcription factor T-bet. Pathobiology 2006; 73:224.
12. Sakaguchi N, Miyai K, Sakaguchi S. Ionizing radiation and autoimmunity. Induction of autoimmune disease in mice by high dose fractionated total lymphoid irradiation and its prevention by inoculating normal T cells. J Immunol 1994; 152:2586.
13. Field J, Biondo MA, Murphy K, Alderuccio F, Toh BH. Experimental autoimmune gastritis: mouse models of human organ-specific autoimmune disease. Int Rev Immunol 2005; 24:93.
14. Tokuhashi Y, Kikkawa F, Tamakoshi K, Suganuma N, Kuzuya K, Arii Y et al. A randomized trial of cisplatin, vinblastine, and bleomycin versus cyclophosphamide, aclacinomycin, and cisplatin in epithelial ovarian cancer. Oncology 1997; 54:281.
15. Kozarich JW, Worth Jr L, Frank BL, Christner DF, Vanderwall DE, Stubbe J. Sequence- specific isotope effects on the cleavage of DNA by bleomycin. Science 1989; 245: 1396.
16. Burger RM, Peisach J, Horwitz SB. Activated bleomycin. Atransientcomplexofdrug, iron, and oxygen thatdegrades DNA. JBiolChem 1981; 256:11636.
17. Chow MS, Liu LV, Solomon EI. Further insights into the mechanism of the reaction of activated bleomycin with DNA. Proc Natl Acad Sci USA 2008; 105: 13241.
18. Edwards GA, Bernardino Jr VB, Babcock VI, Southam CM. Cataracts in bleomycin-treated rats. Am J Ophthalmol 1975; 80:538.
19. Sakaguchi S, Fukuma K, Kuribayashi K, Masuda T. Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible causeofautoimmunedisease. J Exp Med 1985; 161:72.
20. WangH, ZhaoL, Sun Z, Sun L, ZhangB, ZhaoY. Apotential sideeffectofcyclosporin A: inhibition of CD4(+)CD25(+) regulatory T cells in mice. Transplantation 2006; 82:1484.
21. + T cell subsetthatinhibits this autoimmunepotential. J Exp Med 1993; 177:627.
22. Alard P, Thompson C, Agersborg SS, Thatte J, Setiady Y, Samy E et al. Endogenous oocyteantigensarerequiredforrapidinductionandprogressionofautoimmuneovarian disease following day-thymectomy. J Immunol 2001; 166: 4363.
23. Kobayashi Y, Murakami H, Akbar SM, Matsui H, Onji M. A novel and effective approach ofdevelopingaggressiveexperimental autoimmunegastritisinneonatal thymectomized BALB/c mouse by polyinosinic: polycytidylic acid. Clin Exp Immuno 2004; 136:423.
24. Kojima A, Tanaka-Kojima Y, Sakakura T, Nishizuka Y. Spontaneous development of autoimmunethyroiditisinneonatallythymectomizedmice. LabInvest 1976; 34:550.
25. Tung KS, Smith S, Teuscher C, Cook C, Anderson RE. Murine autoimmune oophoritis, epididymoorchitis, andgastritisinducedbyday3thymectomy. Immunopathology. Am J Pathol 1987; 126:293.
26. Taguchi O, Nishizuka Y. Experimental autoimmune orchitis after neonatal thymectomy in the mouse. Clin Exp Immunol 1981; 46:425.
27. Haneji N, Hamano H, Yanagi K, Hayashi Y. A new animal model for primary Sjogren's syndromein NFS/sld mutantmice. J Immunol 1994; 153: 2769.
28. Takada K, Takiguchi M, Inaba M. Different effects on the inflammatory lesions in the lacrimal and salivary glands after neonatal thymectomy in IQI/Jic mice, a model for Sjogren's syndrome. JVet Med Sci 2005; 67:955.