17β-Estradiol attenuates vascular contraction through inhibition of RhoA/Rho kinase pathway

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 380, Issue 1, 2009, Pages 35-44

  Yang, Enyue ^a,b   Jeon, Su Bun ^a   Baek, Inji ^a   Chen, Zheng Ai ^b   Jin, Zheng ^b   Kim, In Kyeom ^a  

^a Kyungpook National University School of Medicine   (South Korea)

^b YANBIAN UNIVERSITY   (China)

Author keywords

17 estradiol; CPI 17; MYPT1; Rho kinase; RhoA; Vasorelaxation

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ESTRADIOL; MYOSIN LIGHT CHAIN; PROTEIN MYPT1; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; ESTROGEN; MYOSIN LIGHT CHAIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE; PPP1R12A PROTEIN, HUMAN; PPP1R14A PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA CONSTRICTION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HEART CONTRACTION; MALE; NONHUMAN; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; ANIMAL; DOSE RESPONSE; DRUG ANTAGONISM; METABOLISM; PHOSPHORYLATION; SPRAGUE DAWLEY RAT; THORACIC AORTA; VASCULAR ENDOTHELIUM; VASOCONSTRICTION;

ANIMALS; AORTA, THORACIC; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ESTRADIOL; ESTROGENS; MALE; MYOSIN LIGHT CHAINS; MYOSIN-LIGHT-CHAIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; VASOCONSTRICTION;

EID: 67349252320     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-009-0408-x     Document Type: Article

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