Antigen loading of DCs with irradiated apoptotic tumor cells induces improved anti-tumor immunity compared to other approaches

Cancer Immunology, Immunotherapy

Volumn 58, Issue 8, 2009, Pages 1257-1264

  Fry, Terry J ^a   Shand, Jessica L ^a   Milliron, Matthew ^a   Tasian, Sarah K ^a   MacKall, Crystal L ^a,b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b 10 Center Drive ^*  (United States)

Author keywords

Antitumor immunity; Cancer vaccines; Dendritic cell vaccines

Indexed keywords

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN DETECTION; ANTIGEN LOADING METHOD; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; DENDRITIC CELL; EPITOPE MAPPING; FEMALE; IMMUNE RESPONSE; IN VIVO STUDY; INTERMETHOD COMPARISON; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIGEN PRESENTATION; APOPTOSIS; CANCER VACCINES; CARCINOMA; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; DENDRITIC CELLS; FEMALE; H-Y ANTIGEN; IMMUNOTHERAPY, ADOPTIVE; INTERLEUKIN-12; MALE; MICE; MICE, INBRED C57BL; URINARY BLADDER NEOPLASMS;

EID: 67349252263     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-008-0638-7     Document Type: Article

References (28)

1. I Mellman RM Steinman 2001 Dendritic cells: specialized and regulated antigen processing machines Cell 106 255 258 (Pubitemid 32772607)
2. P Dubsky H Ueno B Piqueras J Connolly J Banchereau AK Palucka 2005 Human dendritic cell subsets for vaccination J Clin Immunol 25 551 572 (Pubitemid 43011747)
3. S Gallucci M Lolkema P Matzinger 1999 Natural adjuvants: endogenous activators of dendritic cells Nat Med 5 1249 1255 (Pubitemid 29535601)
4. A Iwasaki R Medzhitov 2004 Toll-like receptor control of the adaptive immune responses Nat Immunol 5 987 995 (Pubitemid 41057715)
5. RM Steinman M Pope 2002 Exploiting dendritic cells to improve vaccine efficacy J Clin Invest 109 1519 1526 (Pubitemid 34663511)
6. EJ Small PF Schellhammer CS Higano 2006 Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer J Clin Oncol 24 3089 3094 (Pubitemid 46638945)
7. SA Rosenberg JC Yang NP Restifo 2004 Cancer immunotherapy: moving beyond current vaccines Nat Med 10 909 915 (Pubitemid 39273730)
8. T Osada TM Clay CY Woo MA Morse HK Lyerly 2006 Dendritic cell-based immunotherapy Int Rev Immunol 25 377 413
9. SH Jackson C Alicea JW Owens CL Eigsti HL Malech 2002 Characterization of an early dendritic cell precursor derived from murine lineage-negative hematopoietic progenitor cells Exp Hematol 30 430 439 (Pubitemid 34556734)
10. F Melchionda MK McKirdy F Medeiros TJ Fry CL Mackall 2004 Escape from immune surveillance does not result in tolerance to tumor-associated antigens J Immunother 27 329 338 (Pubitemid 39121921)
11. RC Fields K Shimizu JJ Mule 1998 Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responses in vitro and in vivo Proc Natl Acad Sci USA 95 9482 9487 (Pubitemid 28506257)
12. F Melchionda TJ Fry MJ Milliron MA McKirdy Y Tagaya CL Mackall 2005 Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool J Clin Invest 115 1177 1187 (Pubitemid 40629036)
13. DW O'Neill S Adams N Bhardwaj 2004 Manipulating dendritic cell biology for the active immunotherapy of cancer Blood 104 2235 2246 (Pubitemid 39331818)
14. DM Scott IE Ehrmann PS Ellis PR Chandler E Simpson 1997 Why do some females reject males? The molecular basis for male-specific graft rejection J Mol Med 75 103 114 (Pubitemid 27119490)
15. K Liu T Iyoda M Saternus Y Kimura K Inaba RM Steinman 2002 Immune tolerance after delivery of dying cells to dendritic cells in situ J Exp Med 196 1091 1097 (Pubitemid 35231767)
16. DV Krysko K D'Herde P Vandenabeele 2006 Clearance of apoptotic and necrotic cells and its immunological consequences Apoptosis 11 1709 1726 (Pubitemid 44371047)
17. TA Ferguson H Kazama 2005 Signals from dying cells: tolerance induction by the dendritic cell Immunol Res 32 99 108 (Pubitemid 41153617)
18. B Sauter ML Albert L Francisco M Larsson S Somersan N Bhardwaj 2000 Consequences of cell death: exposure to necrotic tumor cells, but not primary tissue cells or apoptotic cells, induces the maturation of immunostimulatory dendritic cells J Exp Med 191 423 434
19. RM Steinman S Turley I Mellman K Inaba 2000 The induction of tolerance by dendritic cells that have captured apoptotic cells J Exp Med 191 411 416
20. AE Morelli 2006 The immune regulatory effect of apoptotic cells and exosomes on dendritic cells: its impact on transplantation Am J Transplant 6 254 261 (Pubitemid 43382160)
21. AK Nowak RA Lake AL Marzo 2003 Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-tolerizing host tumor-specific CD8 T cells J Immunol 170 4905 4913 (Pubitemid 36554719)
22. A Ronchetti P Rovere G Iezzi 1999 Immunogenicity of apoptotic cells in vivo: role of antigen load, antigen-presenting cells, and cytokines J Immunol 163 130 136 (Pubitemid 29295833)
23. UE Schaible F Winau PA Sieling 2003 Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis Nat Med 9 1039 1046 (Pubitemid 37021784)
24. ML Albert B Sauter N Bhardwaj 1998 Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs Nature 392 86 89 (Pubitemid 28150594)
25. V Russo S Tanzarella P Dalerba 2000 Dendritic cells acquire the MAGE-3 human tumor antigen from apoptotic cells and induce a class I-restricted T cell response Proc Natl Acad Sci USA 97 2185 2190 (Pubitemid 30134043)
26. TA Ferguson J Herndon B Elzey TS Griffith S Schoenberger DR Green 2002 Uptake of apoptotic antigen-coupled cells by lymphoid dendritic cells and cross-priming of CD8(+) T cells produce active immune unresponsiveness J Immunol 168 5589 5595 (Pubitemid 34556139)
27. M Obeid T Panaretakis N Joza 2007 Calreticulin exposure is required for the immunogenicity of gamma-irradiation and UVC light-induced apoptosis Cell Death Differ 14 1848 1850 (Pubitemid 47423653)
28. N Casares MO Pequignot A Tesniere 2005 Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death J Exp Med 202 1691 1701 (Pubitemid 41815875)