Aspirin is insufficient in inhibition of platelet aggregation and thromboxane formation early after coronary artery bypass surgery

Journal of Thrombosis and Thrombolysis

Volumn 27, Issue 4, 2009, Pages 394-399

  Bednar, Frantisek ^a   Osmancik, Pavel ^a   Hlavicka, Jan ^a   Jedlickova, Vera ^b   Paluch, Zoltan ^b   Vanek, Tomas ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b FAKULTNÍ THOMAYEROVA NEMOCNICE   (Czech Republic)

Author keywords

Aggregability; Aspirin; Coronary artery bypass surgery; Thromboxane

Indexed keywords

11 OXOTHROMBOXANE B2; ACETYLSALICYLIC ACID; ARACHIDONIC ACID; THROMBOXANE;

AGED; ANTICOAGULANT THERAPY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BYPASS SURGERY; DOSE RESPONSE; DRUG EFFICACY; FEMALE; GRAFT PATENCY; HUMAN; MALE; OFF PUMP CORONARY SURGERY; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PERIOD; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE COUNT; THROMBOCYTOPOIESIS; THROMBOSIS; THROMBOSIS PREVENTION; URINALYSIS;

AGED; ASPIRIN; CARDIOVASCULAR DISEASES; CORONARY ARTERY BYPASS; FEMALE; HUMANS; MALE; MIDDLE AGED; PLATELET AGGREGATION; PROSPECTIVE STUDIES; THROMBOXANES;

EID: 67349240146     PISSN: 09295305     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11239-008-0225-y     Document Type: Article

References (14)

1. Mangano DT (2002) Aspirin and mortality from coronary bypass surgery. N Engl J Med 347:1309-1317
2. Stein PD, Schunemann HJ, Dalen JE et al (2004) Antithrombotic therapy in patients with saphenous vein and internal mammary artery bypass grafts: the seventh ACCP conference on antithrombotic and thrombolytic therapy. Chest 126:600S-608S
3. Zimmermann N, Kienzle P, Weber AA et al (2001) Aspirin resistance after coronary artery bypass grafting. J Thorac Cardiovasc Surg 121:982-984
4. Zimmermann N, Wenk A, Kim U et al (2003) Functional and biochemical evaluation of platelet aspirin resistance after coronary artery bypass surgery. Circulation 108:542-547
5. Lordkipanidze M, Pharand C, Schampaert E et al (2007) A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease. Eur Heart J 28:1702-1708
6. Cattaneo M (2007) Laboratory detection of 'aspirin resistance': What test should we use (if any)? Eur Heart J 28:1673-1675
7. Muriithi EW, Belcher PR, Day SP et al (2000) Heparin-induced platelet dysfunction and cardiopulmonary bypass. Ann Thorac Surg 69:1827-1832
8. DiChiara J, Bliden KP, Tantry US et al (2007) The effect of aspirin dosing on platelet function in diabetic and nondiabetic patients: An analysis from the aspirin-induced platelet effect (ASPECT) study. Diabetes 56:3014-3019
9. FitzGerald GA, Reilly IA, Pedersen AK (1985) The biochemical pharmacology of thromboxane synthase inhibition in man. Circulation 72:1194-1201
10. Fritsma GA, Ens GE, Alvord MA et al (2001) Monitoring the antiplatelet action of aspirin. JAAPA 14:57-58, 61-62
11. 2 metabolites in humans. Thromb Res 47:647-656
12. Eikelboom JW, Hirsh J, Weitz JI et al (2002) Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. Circulation 105:1650-1655
13. Vane JR, Bakhle YS, Botting RM (1998) Cyclooxygenases 1 and 2. Ann Rev Pharmacol Toxicol 38:97-120
14. Maree AO, Fitzgerald DJ (2007) Variable platelet response to aspirin and clopidogrel in atherothrombotic disease. Circulation 115:2196-2207