Hypovolaemia-induced mild hypoxia produces subchronic metabolic dysfunction

International Journal of Obesity

Volumn 33, Issue 5, 2009, Pages 605-

  Thornton, S N ^a  

^a UNIVERSITÉ DE LORRAINE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; OXYGEN;

ADIPOSE TISSUE; CELL ACTIVITY; CELL FUNCTION; CELL METABOLISM; DIABETES MELLITUS; DISEASE EXACERBATION; FLUID THERAPY; GLYCOLYSIS; HUMAN; HYPERTENSION; HYPOVOLEMIA; HYPOXEMIA; HYPOXIA; INFECTION RISK; INSULIN RESISTANCE; LETTER; METABOLIC DISORDER; MITOCHONDRION; NEOPLASM; OBESITY; OXYGEN TRANSPORT; PREOPERATIVE PERIOD; PRIORITY JOURNAL; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; TISSUE PERFUSION; WOUND INFECTION;

ADIPOSE TISSUE; ANIMALS; CELL HYPOXIA; HUMANS; HYPOVOLEMIA; METABOLIC DISEASES; OBESITY; RATS;

EID: 67349235568     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2009.26     Document Type: Letter

References (7)

1. Ye J. Emerging role of adipose tissue hypoxia in obesity and insulin resistance. Int J Obes (Lond) 2009; 33: 54-66.
2. Kabon B, Nagele A, Reddy D, Eagon C, Fleshman JW, Sessler DI et al. Obesity decreases perioperative tissue oxygenation. Anesthesiology 2004; 100: 274-280.
3. Arkiliç- CF, Taguchi A, Sharma N, Ratnaraj J, Sessler DI, Read TE et al. Supplemental perioperative fluid administration increases tissue oxygen pressure. Surgery 2003; 133: 49-55.
4. Henriksen EJ. Improvement of insulin sensitivity by antagonism of the renin-angiotensin system. Am J Physiol Regul Integr Comp Physiol 2007; 293: R974-R980.
5. Nangaku M, Fujita T. Activation of the renin-angiotensin system and chronic hypoxia of the kidney. Hypertens Res 2008; 31: 175-184.
6. Dunn A, Lo V, Donnelly S. The role of the kidney in blood volume regulation: the kidney as a regulator of the hematocrit. Am J Med Sci 2007; 334: 65-71.
7. Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006; 3: 177-185.