Differential expression of potassium ion channels in human renal cell carcinoma

International Urology and Nephrology

Volumn 41, Issue 2, 2009, Pages 251-257

  Wadhwa, Surbhi ^a,b   Wadhwa, Pankaj ^a,b   Dinda, Amit K ^a   Gupta, Narmada P ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b ST STEPHEN S HOSPITAL   (India)

Author keywords

Carcinoma; Immunohistochemistry; Ion channels; Kidney; Western blot

Indexed keywords

PARAFORMALDEHYDE; POLYCLONAL ANTIBODY; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL HERG ANTIBODY; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ARTICLE; CLEAR CELL CARCINOMA; CLINICAL ARTICLE; CONTROLLED STUDY; CRYOPRESERVATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KIDNEY CARCINOMA; KIDNEY DISTAL TUBULE; KIDNEY PARENCHYMA; KIDNEY PROXIMAL TUBULE; PROTEIN EXPRESSION; TISSUE PRESERVATION; WESTERN BLOTTING;

CARCINOMA, RENAL CELL; CASE-CONTROL STUDIES; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; KIDNEY NEOPLASMS; NEOPLASM INVASIVENESS; NEOPLASM STAGING; NEPHRECTOMY;

EID: 67349234461     PISSN: 03011623     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11255-008-9459-z     Document Type: Article

References (19)

1. Yellen G (2002) The voltage-gated potassium channels and their relatives. Nature 419:35-42. doi: 10.1038/nature00978
2. + channels in T lymphocytes: Functional consequences for volume regulation. Proc Natl Acad Sci USA 90:10036-10040. doi: 10.1073/ pnas.90.21.10036
3. Wonderlin WF, Strobl JS (1996) Potassium channels, proliferation and G1 progression. J Membr Biol 154(2):91-107. doi: 10.1007/s002329900135
4. Schwab A (2001) Function and spatial distribution of ion channels and transporters in cell migration. Am J Physiol Renal Physiol 280(5):F739-F747
5. (+) channels. EMBO J 18:5540-5547. doi: 10.1093/emboj/18.20.5540
6. Meyer R, Heinemann SH (1998) Characterization of an eag-like potassium channel in human neuroblastoma cells. J Physiol 508(Pt 1):49-56
7. Gavrilova-Ruch O, Schonherr K, Gessner G, Schonherr R, Klapperstuck T, Wohlrab W et al (2002) Effects of imipramine on ion channels and proliferation of IGR1 melanoma cells. J Membr Biol 188:137-149. doi: 10.1007/s00232-001-0181-3
8. Farias LM, Ocana DB, Diaz L, Larrea F, Avila-Chavez E, Cadena A et al (2004) Ether a go-go potassium channels as human cervical cancer markers. Cancer Res 64(19):6996-7001. doi: 10.1158/0008-5472.CAN-04-1204
9. Hemmerlein B, Weseloh RM, de Queiroz FM, Knötgen H, Sánchez A, Rubio ME et al (2006) Overexpression of Eag1 potassium channels in clinical tumours. Mol Cancer 5:41. doi: 10.1186/1476-4598-5-41
10. Pardo LA, del Camino D, Sanchez A, Alves F, Bruggemann A, Beckh S et al (1999) Oncogenic potential of EAG K(+) channels. EMBO J 18:5540-5547. doi: 10.1093/emboj/18.20.5540
11. Ju M, Wray D (2002) Molecular identification and characterization of human EAG2 potassium channel. FEBS Lett 524(1-3):204-210. doi: 10.1016/ S0014-5793(02)03055-7
12. Abdul M, Hoosein N (2002) Voltage-gated potassium ion channels in colon cancer. Oncol Rep 9(5):961-964
13. Abdul M, Hoosein N (2002) Expression and activity of potassium ion channels in human prostate cancer. Cancer Lett 186(1):99-105. doi: 10.1016/S0304-3835(02)00348-8
14. Cherubini A, Taddei GL, Crociani O, Paglierani M, Buccoliero AM, Fontana L et al (2000) HERG potassium channels are more frequently expressed in human endometrial cancer as compared to non-cancerous endometrium. Br J Cancer 83(12):1722-1729. doi: 10.1054/bjoc.2000.1497
15. + current highly conserved in tumors of different histogenesis: A selective advantage for cancer cells? Cancer Res 58(4):815-822
16. Pillozzi S, Brizzi MF, Balzi M, Crociano O, Cherubini A, Guasti L et al (2002) HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate proliferation of normal and leukemic hematopoietic progenitors. Leukemia 16(9):1791-1798. doi: 10.1038/sj.leu.2402572
17. Cayabyab FS, Schlichter LC (2002) Regulation of an ERG. J Biol Chem 277(16):13673-13681. doi: 10.1074/jbc.M108211200
18. + channel, a regulator of tumor cell apoptosis and proliferation. Cancer Res 62(17):4843-4848
19. + channel expression-related chemosensitivity in cancer cells and its modulation by erythromycin. Cancer Chemother Pharmacol 56:212-220. doi: 10.1007/ s00280-004-0960-5