Dietary administration in rodent studies distorts the tissue deposition profile of lanthanum carbonate; brain deposition is a contamination artefact?

Toxicology Letters

Volumn 188, Issue 3, 2009, Pages 223-229

  Damment, Stephen J P ^a   Cox, Alan G ^b   Secker, Roger ^a  

^a Shire Pharmaceuticals   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Brain; Chronic kidney disease; Contamination; FOSRENOL; Lanthanum carbonate; Phosphate binder

Indexed keywords

LANTHANUM; LANTHANUM CARBONATE; LANTHANUM CHLORIDE; PHOSPHATE BINDING AGENT; TRACE ELEMENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTIFACT; BIOACCUMULATION; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DATA ANALYSIS; DIET; DRUG BLOOD LEVEL; DRUG BONE LEVEL; DRUG CONTAMINATION; DRUG LIVER LEVEL; DRUG TISSUE LEVEL; FEEDING; FEMALE; HEART; KIDNEY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RODENT; SKIN; TIGHT JUNCTION; TISSUE DISTRIBUTION; ULTRASTRUCTURE;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; BLOOD-BRAIN BARRIER; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CONTAMINATION; DRUG EVALUATION, PRECLINICAL; FEMALE; INJECTIONS, INTRAVENOUS; LANTHANUM; MALE; ORGAN SPECIFICITY; RATS; TISSUE DISTRIBUTION;

ANIMALIA; RATTUS; RODENTIA;

EID: 67349233051     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2009.03.020     Document Type: Article

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