Macrolide resistance in Streptococcus pyogenes: prevalence, resistance determinants, and emm types

Diagnostic Microbiology and Infectious Disease

Volumn 64, Issue 3, 2009, Pages 295-299

  Michos, Athanasios G ^a   Bakoula, Chrysanthi G ^a   Braoudaki, Maria ^a   Koutouzi, Foteini I ^a   Roma, Eleftheria S ^a   Pangalis, Anastasia ^b   Nikolopoulou, Georgia ^a   Kirikou, Elena ^b   Syriopoulou, Vassiliki P ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b AGHIA SOPHIA CHILDREN S HOSPITAL   (Greece)

Author keywords

Efflux; emm type; Macrolide resistance; Methylation genes; S. pyogenes

Indexed keywords

ANTIINFECTIVE AGENT; AZITHROMYCIN; CEFTRIAXONE; CHLORAMPHENICOL; CLINDAMYCIN; ERYTHROMYCIN; LINEZOLID; M PROTEIN; MACROLIDE; MOXIFLOXACIN; PENICILLIN G; PROTEIN ERMA; PROTEIN ERMB; PROTEIN MEFA; RIFAMPICIN; STREPTOCOCCUS VACCINE; TETRACYCLINE; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATE; CHILD; CONTROLLED STUDY; GENE IDENTIFICATION; GENE SEQUENCE; GROUP A STREPTOCOCCAL INFECTION; HUMAN; INFANT; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; STREPTOCOCCUS GROUP A; STREPTOCOCCUS PYOGENES;

ANTI-BACTERIAL AGENTS; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; CARRIER PROTEINS; CHILD; CHILD, PRESCHOOL; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; GENES, BACTERIAL; GENOTYPE; HUMANS; INFANT; MACROLIDES; MICROBIAL SENSITIVITY TESTS; SEROTYPING; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PYOGENES;

EID: 67349233039     PISSN: 07328893     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diagmicrobio.2009.03.004     Document Type: Article

References (32)

1. Amezaga M.R., Carter P.E., Cash P., and McKenzie H. Molecular epidemiology of erythromycin resistance in Streptococcus pneumoniae isolates from blood and noninvasive sites. J. Clin. Microbiol. 40 (2002) 3313-3318
2. Bemer-Melchior P., Juvin M.E., Tassin S., Bryskier A., Schito G.C., and Drugeon H.B. In vitro activity of the new ketolide telithromycin compared with those of macrolides against Streptococcus pyogenes: influences of resistance mechanisms and methodological factors. Antimicrob. Agents Chemother. 44 (2000) 2999-3002
3. Bingen E., Fitoussi F., Doit C., Cohen R., Tanna A., George R., Loukil C., Brahimi N., Le Thomas I., and Deforche D. Resistance to macrolides in Streptococcus pyogenes in France in pediatric patients. Antimicrob. Agents Chemother. 44 (2000) 1453-1457
4. Bisno A.L., Brito M.O., and Collins C.M. Molecular basis of group A streptococcal virulence. Lancet Infect. Dis. 3 (2003) 191-200
5. (CLSI). Clinical and Laboratory Standards Institute. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard - sixth edition, M7-A6. 6th ed. (2003), CLSI, Wayne, PA
6. (CLSI). Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing. 15th Informational Supplement (2005), CLSI, Wayne PA M100-M515
7. Cohen-Poradosu R., and Kasper D.L. Group A streptococcus epidemiology and vaccine implications. Clin. Infect. Dis. 45 (2007) 863-865
8. Daikos G.L., Koutsolioutsou A., Tsiodras S., Theodoridou M., Koutouzis E.I., Charissiadou A., Pangalis A., Michos A.G., Chaidopoulou F., Braoudaki M., and Syriopoulou V.P. Evolution of macrolide resistance in Streptococcus pneumoniae clinical isolates in the prevaccine era. Diagn. Microbiol. Infect. Dis. 60 (2008) 393-398
9. Facinelli B., Spinaci C., Magi G., Giovanetti E., and P E.V. Association between erythromycin resistance and ability to enter human respiratory cells in group A streptococci. Lancet 358 (2001) 30-33
10. Farrell D.J., Morrissey I., Bakker S., and Felmingham D. Molecular characterization of macrolide resistance mechanisms among Streptococcus pneumoniae and Streptococcus pyogenes isolated from the PROTEKT 1999-2000 study. J. Antimicrob. Chemother. 50 Suppl S1 (2002) 39-47
11. Giovanetti E., Magi G., Brenciani A., Spinaci C., Lupidi R., Facinelli B., and Varaldo P.E. Conjugative transfer of the erm(A) gene from erythromycin-resistant Streptococcus pyogenes to macrolide-susceptible S. pyogenes, Enterococcus faecalis and Listeria innocua. J. Antimicrob. Chemother. 50 (2002) 249-252
12. Giovanetti E., Montanari M.P., Mingoia M., and Varaldo P.E. Phenotypes and genotypes of erythromycin-resistant Streptococcus pyogenes strains in Italy and heterogeneity of inducibly resistant strains. Antimicrob. Agents Chemother. 43 (1999) 1935-1940
13. Grivea I.N., Al-Lahham A., Katopodis G.D., Syrogiannopoulos G.A., and Reinert R.R. Resistance to erythromycin and telithromycin in Streptococcus pyogenes isolates obtained between 1999 and 2002 from Greek children with tonsillopharyngitis: phenotypic and genotypic analysis. Antimicrob. Agents Chemother. 50 (2006) 256-261
14. Hasenbein M.E., Warner J.E., Lambert K.G., Cole S.E., Onderdonk A.B., and McAdam A.J. Detection of multiple macrolide- and lincosamide-resistant strains of Streptococcus pyogenes from patients in the Boston area. J. Clin. Microbiol. 42 (2004) 1559-1563
15. Ioannidou S., Tassios P.T., Zachariadou L., Salem Z., Kanelopoulou M., Kanavaki S., Chronopoulou G., Petropoulou N., Foustoukou M., Pangalis A., Trikka-Graphakos E., Papafraggas E., and Vatopoulos A.C. In vitro activity of telithromycin (HMR 3647) against Greek Streptococcus pyogenes and Streptococcus pneumoniae clinical isolates with different macrolide susceptibilities. Clin. Microbiol. Infect. 9 (2003) 704-707
16. Jaggi P., Beall B., Rippe J., Tanz R.R., and Shulman S.T. Macrolide resistance and emm type distribution of invasive pediatric group A streptococcal isolates: three-year prospective surveillance from a children's hospital. Pediatr. Infect. Dis. J. 26 (2007) 253-255
17. Jalava J., Vaara M., and Huovinen P. Mutation at the position 2058 of the 23S rRNA as a cause of macrolide resistance in Streptococcus pyogenes. Ann. Clin. Microbiol. Antimicrob. 3 (2004) 5
18. Kanellopoulou M., Makri A., Damaskopoulou H., and Malamou-Lada H. Isolation rate, T-serotyping and susceptibility to antibiotics of group A Streptococcus from pediatric infections in Athens. Clin. Microbiol. Infect. 6 (2000) 653-656
19. Kataja J., Huovinen P., and Seppala H. Erythromycin resistance genes in group A streptococci of different geographical origins. The Macrolide Resistance Study Group. J. Antimicrob. Chemother. 46 (2000) 789-792
20. Malbruny B., Nagai K., Coquemont M., Bozdogan B., Andrasevic A.T., Hupkova H., Leclercq R., and Appelbaum P.C. Resistance to macrolides in clinical isolates of Streptococcus pyogenes due to ribosomal mutations. J. Antimicrob. Chemother. 49 (2002) 935-939
21. McNeil S.A., Halperin S.A., Langley J.M., Smith B., Warren A., Sharratt G.P., Baxendale D.M., Reddish M.A., Hu M.C., Stroop S.D., Linden J., Fries L.F., Vink P.E., and Dale J.B. Safety and immunogenicity of 26-valent group a streptococcus vaccine in healthy adult volunteers. Clin. Infect. Dis. 41 (2005) 1114-1122
22. Nielsen H.U., Hammerum A.M., Ekelund K., Bang D., Pallesen L.V., and Frimodt-Moller N. Tetracycline and macrolide co-resistance in Streptococcus pyogenes: co-selection as a reason for increase in macrolide-resistant S. pyogenes?. Microb. Drug. Resist. 10 (2004) 231-238
23. Petinaki E., Kontos F., Pratti A., Skulakis C., and Maniatis A.N. Clinical isolates of macrolide-resistant Streptococcus pyogenes in Central Greece. Int. J. Antimicrob. Agents 21 (2003) 67-70
24. Richter S.S., Heilmann K.P., Beekmann S.E., Miller N.J., Miller A.L., Rice C.L., Doern C.D., Reid S.D., and Doern G.V. Macrolide-resistant Streptococcus pyogenes in the United States, 2002-2003. Clin. Infect. Dis. 41 (2005) 599-608
25. Seppala H., Haanpera M., Al-Juhaish M., Jarvinen H., Jalava J., and Huovinen P. Antimicrobial susceptibility patterns and macrolide resistance genes of viridans group streptococci from normal flora. J. Antimicrob. Chemother. 52 (2003) 636-644
26. Seppala H., Klaukka T., Vuopio-Varkila J., Muotiala A., Helenius H., Lager K., and Huovinen P. The effect of changes in the consumption of macrolide antibiotics on erythromycin resistance in group A streptococci in Finland. Finnish Study Group for Antimicrobial Resistance. N. Engl. J. Med. 337 (1997) 441-446
27. Stathi A., Papaparaskevas J., Zachariadou L., Pangalis A., Legakis N.J., Tseleni-Kotsovili A., and Tassios P.T. Prevalence of emm types 1 and 12 from invasive Streptococcus pyogenes disease in Greece-results of enhanced surveillance. Clin. Microbiol. Infect. 14 (2008) 808-812
28. Sutcliffe J., Grebe T., Tait-Kamradt A., and Wondrack L. Detection of erythromycin-resistant determinants by PCR. Antimicrob. Agents Chemother. 40 (1996) 2562-2566
29. Syrogiannopoulos G.A., Grivea I.N., Fitoussi F., Doit C., Katopodis G.D., Bingen E., and Beratis N.G. High prevalence of erythromycin resistance of Streptococcus pyogenes in Greek children. Pediatr. Infect. Dis. J. 20 (2001) 863-868
30. Weber P., Filipecki J., Bingen E., Fitoussi F., Goldfarb G., Chauvin J.P., Reitz C., and Portier H. Genetic and phenotypic characterization of macrolide resistance in group A streptococci isolated from adults with pharyngo-tonsillitis in France. J. Antimicrob. Chemother. 48 (2001) 291-294
31. York M.K., Gibbs L., Perdreau-Remington F., and Brooks G.F. Characterization of antimicrobial resistance in Streptococcus pyogenes isolates from the San Francisco Bay area of northern California. J. Clin. Microbiol. 37 (1999) 1727-1731
32. Zachariadou L., Papaparaskevas J., Paraskakis I., Efstratiou A., Pangalis A., Legakis N.J., and Tassios P.T. Predominance of two M-types among erythromycin-resistant group A streptococci from Greek children. Clin. Microbiol. Infect. 9 (2003) 310-314