Characterization of two alternative Interleukin(IL)-10 5′UTR mRNA sequences, induced by lipopolysaccharide (LPS) stimulation of peripheral blood mononuclear cells

Molecular Immunology

Volumn 46, Issue 11-12, 2009, Pages 2161-2166

  Forte, Giusi Irma ^a,b   Scola, Letizia ^a,b   Bellavia, Daniele ^b   Vaccarino, Loredana ^a,b   Sanacore, Maria ^a,b   Sisino, Giorgia ^b   Scazzone, Concetta ^b   Caruso, Calogero ^b   Barbieri, Rainer ^b   Lio, Domenico ^a,b  

^a Department of Experimental Medicine   (Italy)

^b UNIVERSITY OF PALERMO   (Italy)

Author keywords

5 UTR region; Interleukin(IL) 10; LPS stimulation; mRNA; Secondary structures

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; INTERLEUKIN 10; MESSENGER RNA; NUCLEOTIDE;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; ARTICLE; BLOOD SAMPLING; CELL STIMULATION; CONTROLLED STUDY; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROCESSING; PROTEIN SECONDARY STRUCTURE; PROTEIN SYNTHESIS; TEMPERATURE;

5' UNTRANSLATED REGIONS; BASE SEQUENCE; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-10; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; REGULATORY SEQUENCES, NUCLEIC ACID; RNA, MESSENGER;

BACTERIA (MICROORGANISMS);

EID: 67349225096     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.04.034     Document Type: Article

References (47)

1. Affymetrix/Cold Spring Harbor Laboratory ENCODE Transcriptome Project, Fejes-Toth, K., Sotirova, V., Sachidanandam, R., Assaf, G., Hannon, G.J., Kapranov, P., Foissac, S., Willingham, A.T., Duttagupta, R., Dumais, E., Gingeras, T.R., 2009. Post-transcriptional processing generates a diversity of 5′-modified long and short RNAs. Nature 457, 1028-1032.
2. Bamford R.N., Battiata A.P., Burton J.D., Sharma H., and Waldmann T.A. Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type IR region/IL-15 fusion message that lacks many upstream AUGs that normally attenuate IL-15 mRNA translation. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 2897-2902
3. Bellavia D., Forte G.I., Sisino G., Sisino G., and Barbieri R. A new method for the mapping of 5′ ends of RNAs. Anal. Biochem. 378 (2008) 113-114
4. Ben-Asouli Y., Banai Y., Pel-Or Y., Shir A., and Kaempfer R. Human interferon-γ mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR. Cell 108 (2002) 221-232
5. Benkhart E.M., Siedlar M., Wedel A., Werner T., and Ziegler-Heitbrock H.W. Role of Stat3 in lipopolysaccharide-induced IL-10 gene expression. J. Immunol. 165 (2000) 1612-1617
6. Brenner S., Prosch S., Schenke-Layland K., Riese U., Gausmann U., and Platzer C. cAMP-induced interleukin-10 promoter activation depends on CCAAT/enhancer-binding protein expression and monocytic differentiation. J. Biol. Chem. 278 (2003) 5597-5604
7. Brightbill H.D., Plevy S.E., Modlin R.L., and Smale S.T. A prominent role for Sp1 during lipopolysaccharide-mediated induction of the IL-10 promoter in macrophages. J. Immunol. 164 (2000) 1940-1951
8. Cao S., Liu J., Song L., and Ma X. The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages. J. Immunol. 174 (2005) 3484-3492
9. Chiang B.T., Liu Y.W., Chen B.K., Wang J.M., and Chang W.C. Direct interaction of C/EBPd and Sp1 at the GC-enriched promoter region synergizes the IL-10 gene transcription in mouse macrophage. Biomed. Sci. 13 (2006) 621-635
10. Csóka B., Németh Z.H., Virág L., Gergely P., Leibovich S.J., Pacher P., Sun C.X., Blackburn M.R., Vizi E.S., Deitch E.A., and Haskó G. A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli. Blood 110 (2007) 2685-2695
11. D'Alfonso S., Rampi M., Rolando V., Giordano M., and Momigliano-Richiardi P. New polymorphisms in the IL-10 promoter region. Genes Immun. 1 (2000) 231-233
12. Davuluri R.V., Suzuki Y., Sugano S., and Zhang M.Q. CART classification of human 5′ UTR sequences. Genome Res. 10 (2000) 1807-1816
13. de Waal Malefyt R., Abrams J., Bennett B., Figdor C.G., and de Vries J.E. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J. Exp. Med. 174 (1991) 1209-1920
14. Donger C., Georges J.L., Nicaud V., Morrison C., Evans A., Kee F., Arveiler D., Tiret L., and Cambien F. New polymorphisms in the interleukin-10 gene-relationships to myocardial infarction. Eur. J. Clin. Invest. 31 (2001) 9-14
15. Eskdale J., Kube D., Tesch H., and Gallagher G. Mapping. of the human IL-10 gene and further characterization of the 5′ flanking sequence. Immunogenetics 46 (1997) 120-128
16. Eskdale J., Gallagher G., Verweij C.L., Keijsers V., Westendorp R.G., and Huizinga T.W. Interleukin 10 secretion in relation to human IL-10 locus haplotypes. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 9465-9470
17. Eskdale J., Keijsers V., Huizinga T., and Gallagher G. Microsatellite alleles and single nucleotide polymorphisms (SNP) combine to form four major haplotype families at the human interleukin-10 (IL-10) locus. Genes Immun. 1 (1999) 151-155
18. Espel E. The role of the AU-rich elements of mRNAs in controlling translation. Semin. Cell. Dev. Biol. 16 (2005) 59-67
19. Gilroy D.W., Lawrence T., Perretti M., and Rossi A.G. Inflammatory resolution: new opportunities for drug discovery. Nat. Rev. Drug Discov. 3 (2004) 401-416
20. Guo X., Gerl R.E., and Schrader J.W.J. Defining the involvement of p38alpha MAPK in the production of anti- and proinflammatory cytokines using an SB 203580-resistant form of the kinase. Biol. Chem. 278 (2003) 22237-22242
21. Johansson J., Mandin P., Tenzoni A., Chiaruttini C., Sprinter M., and Cossart P. An RNA thermosensor controls expression of virulence genes in Listeria monocytogenes. Cell 110 (2002) 551-561
22. Kaempfer R. RNA sensor: novel regulators of gene expression. EMBO Rep. 4 (2003) 1043-1047
23. Kim S.J., Park K., Koellers D., Kim K.Y., Wakefield L.M., Sporn M.B., and Roberts A.B. Post-transcriptional regulation of the human transforming growth factor-1 gene. J. Biol. Chem. 267 (1992) 13702-13707
24. Kozak M. The scanning model for translation: an update. J. Cell Biol. 108 (1989) 229-241
25. Kube D., Platzer C., von Knethen A., Straub H., Bohlen H., Hafner M., and Tesh H. Isolation of the human interleukin 10 promoter. Characterization of the promoter activity in Burkitt's lymphoma cell lines. Cytokine 7 (1995) 1-7
26. Kube D., Rieth H., Eskdale J., Kremsner P.G., and Gallagher G. Structural characterisation of the distal 5′ flanking region of the human interleukin-10 gene. Genes Immun. 2 (2001) 181-190
27. Lio D., Candore G., Colombo A., Colonna Romano G., Gervasi F., Marino V., Scola L., and Caruso C. A genetically determined high setting of TNF-α influences immunological parameters of HLA-B8,DR3 positive subjects: implications for autoimmunity. Hum. Immunol. 62 (2001) 705-713
28. Lio D., Scola L., Crivello A., Colonna-Romano G., Candore G., Bonafe M., Cavallone L., Franceschi C., and Caruso C. Gender-specific association between -1082 IL-10 promoter polymorphism and longevity. Genes Immun. 3 (2002) 30-33
29. Lio, D., Caruso, C., 2006. In: Marincola, F.M. (Ed.), Interleukin-10. Eureka Com, Georgetown, Texas, USA, pp. 93-106.
30. Liu Y.W., Tseng H.P., Chen L.C., Chen B.K., and Chang W.C. Functional cooperation of simian virus 40 promoter factor 1 and CCAAT/enhancer-binding protein and in lipopolysaccharide-induced gene activation of IL-10 in mouse macrophages. J. Immunol. 171 (2003) 821-828
31. Liu Y.W., Chen C.C., Tseng H.P., and Chang W.C. Lipopolysaccharide-induced transcriptional activation of interleukin-10 is mediated by MAPK- and NF-κB-induced CCAAT/enhancer-binding protein δ in mouse macrophages. Cell. Signal. 18 (2006) 1492-1500
32. Matzura O., and Wennborg A. RNAdraw: an integrated program for RNA secondary structure calculation and analysis under 32-bit Microsoft Windows. Comput. Appl. Biosci. 12 (1996) 247-249
33. Maxam A.M., and Gilbert W. A new method for sequencing DNA. Proc. Natl. Acad. Sci. U.S.A. 74 (1977) 560-564
34. Miller S.A., Dykes D.D., and Polesky H.F. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 16 (1998) 1215
35. Momand J., Zambetti G.P., Olson D.C., George D., and Levine A.J. The MDM2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation. Cell 69 (1992) 1237-1245
36. Moore K.W., de Waal Malefyt R., Coffman R.L., and O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19 (2001) 683-765
37. Mosmann T.R., Schumacher J.H., Fiorentino D.F., Leverah J., Moore K.W., and Bond M.W. Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay. J. Immunol. 145 (1990) 2938-2945
38. Németh Z.H., Lutz C.S., Csóka B., Deitch E.A., Leibovich S.J., Gause W.C., Tone M., Pacher P., Vizi E.S., and Haskó G. Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism. J. Immunol. 175 (2005) 8260-8270
39. Osman F., Jarrous N., Ben-Asouli Y., and Kaempfer R. A cis-acting element in the 3′-untranslated region of human TNF-α mRNA renders splicing dependent on the activation of protein kinase PKR. Genes Dev. 13 (1999) 3280-3293
40. Powell M.J., Thompson S.A.J., Tone Y., Waldmann H., and Tone M. Posttranscriptional regulation of IL-10 gene expression through sequences in the 3′untranslated region. J. Immunol. 165 (2000) 292-296
41. Suarez A., Castro P., Alonso R., Mozo L., and Gutierrez C. Interindividual variations in constitutive interleukin-10 messenger RNA and protein levels and their association with genetic polymorphisms. Transplantation 75 (2003) 711-717
42. Turner D.M., Williams D.M., Sankaran D., Lazarus M., Sinnott P.J., and Hutchinson I.V. An investigation of polymorphism in the interleukin-10 gene promoter. Eur. J. Immunogenet. 24 (1997) 1-8
43. Van der Velden A., and Thomas A.A. The role of 5′untranslated region of an mRNA in translational regulation during development. Int. J. Biochem. Cell Biol. 31 (1999) 87-106
44. Westendorp R.G., Langermans J.A., Huizinga T.W., Verweij C.L., and Sturk A. Genetic influence on cytokine production and fatal meningococcal disease. Lancet 349 (1997) 170-173
45. Willis A.E. Translational control of growth factor and proto-oncogene expression. Int. J. Biochem. Cell Biol. 31 (1999) 73-86
46. Zhang T., Kruys V., Huez G., and Gueydan C. AU-rich element-mediated translational control: complexity and multiple activities of trans-activating factors. Biochem. Soc. Trans. 30 (2002) 952-958
47. Zhang X., Edwards J.P., and Mosser D.M. Dynamic and transient remodeling of the macrophage IL-10 promoter during transcription. J. Immunol. 177 (2006) 1282-1288