A new anorexigenic protein, nesfatin-1

Peptides

Volumn 30, Issue 5, 2009, Pages 995-998

  Shimizu, Hiroyuki ^a   Ohsaki, Aya ^a   Oh I, Sinsuke ^a   Okada, Shuichi ^a   Mori, Masatomo ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Body weight; Food intake; Leptin; Melanocortin; Nesfatin 1

Indexed keywords

AMPHETAMINE; ANOREXIGENIC AGENT; COCAINE; MELANIN; MELANOCORTIN; MESSENGER RNA; NESFATIN 1; OXYTOCIN; PROOPIOMELANOCORTIN; UNCLASSIFIED DRUG; VASOPRESSIN;

BRAIN STEM; DRUG INHIBITION; EXPERIMENTAL RAT; HYPOTHALAMUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; REVIEW;

ANIMALS; ANOREXIA; APPETITE DEPRESSANTS; INJECTIONS, INTRAVENTRICULAR; MALE; NERVE TISSUE PROTEINS; RATS; RATS, WISTAR; RATS, ZUCKER;

ANIMALIA; RATTUS;

EID: 67349224649     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2009.01.002     Document Type: Review

References (19)

1. Brailoiu G.C., Dun S.L., Braoiu E., Inan S., Yang J., Chang J.K., et al. Nesfatin-1: distribution and interaction with a G protein-coupled receptor in the rat brain. Endocrinology 148 (2007) 5088-5094
2. Date Y., Murakami N., Toshinai K., Matsukura S., Niijima A., Matsuo H., et al. The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 123 (2002) 1120-1128
3. Douglas A.J., Johnstone L.E., and Leng G. Neuroendocrine mechanism of change in food intake during pregnancy: a potential role for brain oxytocin. Physiol Behav 91 (2007) 352-365
4. Foo K.S., Brismar H., and Broberger C. Distribution and neuropeptide coexistence of nucleobindin-2 mRNA/nesfatin-like immunoreactivity in the rat CNS. Neuroscience 156 (2008) 563-579
5. Fort P., Salvert D., Hanriot L., Jego S., Shimizu H., Hashimoto K., et al. The satiety molecule nesfatin-1 is co-expressed with melanin concentrating hormone in tuberal hypothalamic neurons of the rat. Neuroscience 155 (2008) 174-178
6. Inhoff T., Mönnikes H., Noetzel S., Stengel A., Goebel M., Dinh Q.T., et al. Desacyl ghrelin inhibits the orexigenic effect of peripherally injected ghrelin in rats. Peptides 29 (2008) 2159-2168
7. Koda S., Date Y., Murakami N., Shimbara T., Handa T., Toshinai K., et al. The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats. Endocrinology 146 (2005) 2369-2375
8. Kohno D., Nakata M., Maejima Y., Shimizu H., Sedbazar U., Yoshida N., et al. Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding. Endocrinology 149 (2008) 1295-1301
9. Merali Z., Cayer C., Kent P., and Anisman H. Nesfatin-1 increases anxiety- and fear-related behaviors in the rat. Psychopharmacology (Berlin) 201 (2008) 115-123
10. Oh-I, Shimizu H., Satoh T., Okada S., Adachi S., Inoue K., et al. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 443 (2006) 709-712
11. Pan W., Hsuchou H., and Kastin A.J. Nesfatin-1 crosses the blood-brain barrier without saturation. Peptides 28 (2007) 2223-2228
12. Price C.J., Samson W.K., and Ferguson A.V. Nesfatin-1 inhibits NPY neurons in the arcuate nucleus. Brain Res 1230 (2008) 99-106
13. Price C.J., Hoyda T.D., Samson W.K., and Ferguson A.V. Nesfatin-1 influences the excitability of paraventricular nucleus neurons. J Neuroendocrinol 20 (2008) 245-250
14. Price T.O., Samson W.K., Niehoff M.L., and Banks W.A. Permeability of the blood-brain barrier to a novel satiety molecule nesfatin-1. Peptides 28 (2007) 2372-2381
15. Shimizu H., and Mori M. The brain-adipose axis. Nutr Neruosci 8 (2005) 7-20
16. Shimizu H., Tsuchiya T., Sato N., Shimomura Y., Kobayashi I., and Mori M. Troglitazone reduces plasma leptin concentration but increases hunger in NIDDM patients. Diabetes Care 21 (1998) 1470-1474
17. Shimizu H, Oh-I S, Hashimoto K, Nakata M, Yamamoto S, Yoshida N, Eguchi H, Kato I, Inoue K, Satoh T, Okada S, Yamada M, Yada T, Mori M. Peripheral administration of nesfatin-1 reduces food intake in mice: the leptin-independent mechanism. Endocrinology; in press.
18. Stengel A, Goebel M, Yakubov I, Wang L, Witcher D, Coskun T, Taché Y, Sachs G, Lambrecht NW. Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa. Endocrinology [Epub ahead of print].
19. Talsamina T., Anini Y., Siu S., Drucker D.J., and Brubaker P.L. Peripheral extendin-4 and peptide YY3-36 synergistically reduce food intake through different mechanisms in mice. Endocrinology 146 (2005) 3748-3756