Anorexia-Cachexia Syndrome: A Systematic Review of the Role of Dietary Polyunsaturated Fatty Acids in the Management of Symptoms, Survival, and Quality of Life

Journal of Pain and Symptom Management

Volumn 37, Issue 6, 2009, Pages 1069-1077

  Mazzotta, Paolo ^a   Jeney, Christa M ^a  

^a ST JOSEPH S HEALTH CENTRE   (Canada)

Author keywords

Anorexia; anorexia cachexia syndrome; cachexia; docosahexaenoic acid; eicosapentaenoic acid; palliative care; polyunsaturated fatty acids; quality of life; survival

Indexed keywords

DEXAMETHASONE; DOCOSAHEXAENOIC ACID; DRONABINOL; IBUPROFEN; ICOSAPENTAENOIC ACID; INDOMETACIN; MEDROXYPROGESTERONE; MEGESTROL ACETATE; MELATONIN; METHYLPREDNISOLONE; METOCLOPRAMIDE; PENTOXIFYLLINE; PLACEBO; POLYUNSATURATED FATTY ACID; PREDNISOLONE; THALIDOMIDE;

ANOREXIA; ANOREXIA CACHEXIA SYNDROME; ANTHROPOMETRY; BODY WEIGHT; CACHEXIA; CLINICAL TRIAL; DIET SUPPLEMENTATION; DRUG EFFICACY; EMBASE; HUMAN; MEDICAL LITERATURE; MEDLINE; MONOTHERAPY; MUSCLE MASS; OUTCOME ASSESSMENT; POPULATION; QUALITY OF LIFE; REVIEW; SURVIVAL; SYMPTOM; SYSTEMATIC REVIEW; TREATMENT OUTCOME; WEIGHT CHANGE;

ANOREXIA; CACHEXIA; DIETARY FATS; EICOSAPENTAENOIC ACID; FATTY ACIDS, UNSATURATED; HUMANS; KARNOFSKY PERFORMANCE STATUS; NEOPLASMS; QUALITY OF LIFE; SURVIVAL; SYNDROME;

EID: 67349203645     PISSN: 08853924     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpainsymman.2008.06.005     Document Type: Review

References (17)

1. Ma G., and Alexander H.R. Prevalence and pathophysiology of cancer cachexia. In: Bruera E., and Portenoy R.K. (Eds). Topics in palliative care (1998), Oxford University Press, New York 91-129
2. Oi-Ling K., Man-Wah D.T., and Kam-Hung D.N. Symptom distress as rated by advanced cancer patients, caregivers and physicians in the last week of life. Palliat Med 19 3 (2005) 228-233
3. MacDonald N., Easson A.M., Mazurak V.C., et al. Understanding and managing cancer cachexia. J Am Coll Surg 197 1 (2003) 143-161
4. Yavuzsen T., Davis M.P., Walsh D., et al. Systematic review of the treatment of cancer-associated anorexia and weight loss. J Clin Oncol 23 33 (2005) 8500-8511
5. Wigmore S.J., Fearon K.C.H., Maingay J.P., et al. Down-regulation of the acute-phase response in patients with pancreatic cancer cachexia receiving oral eicosapentaenoic acid is mediated via suppression of interleukin-6. Clin Sci 92 (1997) 215-221
6. Falconer J.S., Ross J.A., Fearon K.C.H., et al. Effect of eicosapentaenoic acid and other fatty acids on the growth in vitro of human pancreatic cancer cell lines. Br J Cancer 69 (1994) 826-832
7. Beck S.A., Smith K.L., and Tisdale M.J. Anticachectic and antitumour effect of eicosapentaenoic acid and its effect on protein turnover. Cancer Res 51 (1991) 6089-6093
8. Gogos C.H., Ginopoulos P., Salsa B., et al. Dietary omega-3 polyunsaturated fatty acids plus vitamin E restore immunodeficiency and prolong survival for severely ill patients with generalized malignancy. Cancer 82 (1998) 395-402
9. Barber M.D., Ross J.A., Preston T., et al. Fish oil-enriched nutritional supplement attenuates progression of the acute-phase response in weight-losing patients with advanced pancreatic cancer. J Nutr 129 (1999) 1120-1125
10. Bruera E., Strasser F., Palmer J.L., et al. Effect of fish oil on appetite and other symptoms in patients with advanced cancer and anorexia/cachexia: a double-blind, placebo-controlled study. J Clin Oncol 21 (2003) 129-134
11. Fearon K.C.H., von Meyenfeldt M.F., Moses A.G.W., et al. Effect of a protein and energy dense n-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial. Gut 52 10 (2003) 1479-1486
12. Jatoi A., Rowland K., Loprinzi C.L., et al. An eicosapentaenoic acid supplement versus megestrol acetate versus both for patients with cancer-associated wasting: a North Central Cancer Treatment Group and National Cancer Institute of Canada Collaborative Effort. J Clin Oncol 22 (2004) 2469-2476
13. Persson C., Glimelius B., Ronnelid J., et al. Impact of fish oil and melatonin on cachexia in patients with advanced gastrointestinal cancer: a randomized pilot study. Nutrition 21 (2005) 170-178
14. Fearon K.C.H., Barber M.D., Moses A.G., et al. Double-blind, placebo-controlled, randomized study of eicosapentaenoic acid diester in patients with cancer cachexia. J Clin Oncol 24 (2006) 3401-3407
15. Wigmore S.J., Ross J.A., Flaconer S., et al. The effect of polyunsaturated fatty acids on the progress of cachexia in patients with pancreatic cancer. Suppl Nutr 12 1 (1996) S27-S30
16. Barber M.D., Ross J.A., Voss A.C., et al. The effect of an oral nutritional supplement enriched with fish oil on weight-loss in patients with pancreatic cancer. Br J Cancer 81 1 (1999) 80-86
17. Mantovani G., Maccio A., Madeddu C., et al. A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anit-cylcooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress. Cancer Epidemiol Biomarkers Prev 15 5 (2006) 1030-1034